Glucose Solution for Infusion 50mg/ml: Essential Information and Safety Guidelines

Glucose Solution for Infusion 50mg/ml: Essential Information and Safety Guidelines

This comprehensive guide provides detailed information on Glucose solution for infusion 50mg/ml, a vital medical solution used to replenish glucose levels in various clinical situations. We cover key aspects including administration, safety, potential interactions, and contraindications.

What is Glucose Solution for Infusion 50mg/ml?

Glucose solution for infusion 50mg/ml is a sterile, non-pyrogenic solution containing 50mg of anhydrous glucose per milliliter. It's available in polymer containers of 250ml and is commonly used in hospitals and medical settings to:

Correct hypoglycemia: This solution effectively raises blood sugar levels in patients experiencing low blood sugar.
Provide essential energy: Glucose is a primary source of energy for the body, and this solution can provide vital fuel during illness, surgery, or trauma.
Support fluid balance: The solution can also be used to help rehydrate patients suffering from dehydration.

Important Administration Guidelines:

Visual inspection: Before administering the solution, always perform a visual inspection of the container. The solution should be clear, free from suspended particles or sediment. Ensure the label is present and the packaging is sealed.
Dosage and infusion rate: The concentration and dosage of the solution depend on the patient's age, body weight, and clinical condition. Dosage is determined by a medical professional, and the infusion rate should not exceed the patient's glucose utilization threshold to avoid hyperglycemia.
Monitoring: Carefully monitor clinical and biological parameters, especially blood glucose concentration and water-salt balance.
Insulin considerations: For better glucose assimilation when administering large doses, insulin may be prescribed simultaneously at a rate of 1 IU of insulin per 4-5 g of glucose.

Safety and Precautions:

Hyperglycemia risk: Prolonged use of glucose solution can lead to hyperglycemia. Careful monitoring is crucial.
Brain injury: Avoid prescribing glucose solution in the acute period of severe traumatic brain injury or acute cerebrovascular accident.
Electrolyte balance: Monitor water and electrolyte balance during treatment.
Pregnancy and lactation: Exercise caution during pregnancy and lactation, as glucose solutions can cause fetal hyperglycemia and metabolic acidosis.
Kidney and heart issues: Use with caution in patients with renal or cardiac insufficiency.
Hypokalemia: Combined administration with potassium supplements is necessary to prevent worsening hypokalemia.
Administration method: Do not use subcutaneously or intramuscularly. Administer slowly through large veins to prevent thrombophlebitis.

Interactions with other Drugs:

Glucose solution is incompatible with several medications, including:

Aminophylline
Soluble barbiturates
Erythromycin
Hydrocortisone
Warfarin
Kanamycin
Soluble sulfonamides
Cyanocobalamin
Blood products

Contraindications:

Glucose solution 50mg/ml is contraindicated in patients with:

Intracranial and intraspinal hemorrhages (except for hypoglycemia-related conditions)
Severe dehydration, including alcoholic delirium
Hypersensitivity to dextrose or other components of the drug
Anuria
Diabetes mellitus and other hyperglycemic conditions
Hyperlactacidemia, hyperosmolar coma
Hyperhydration, cerebral and pulmonary edema, acute left ventricular failure
Circulatory disorders threatening brain and lung swelling

Use with caution in patients with:

Decompensated chronic heart failure
Chronic renal failure (oligo-, anuria)
Hyponatremia
Diabetes mellitus

Overdose:

Overdose may cause hyperglycemia and hyperhydration. Symptoms include:

Dry skin and mucous membranes
Decreased eyeball tension
Frequent shallow breathing without acetone odor
Tachycardia, arrhythmia
Loss of consciousness
Increased body temperature

Side Effects:

Common side effects include:

Hypervolemia
Acute left ventricular failure
Osmotic diuresis
Infection and thrombophlebitis at the injection site
Electrolyte imbalance (hyponatremia, hypokalemia, hypophosphatemia, hypomagnesemia)
Hyperglycemia
Allergic reactions (hyperthermia, skin rash, angioedema, shock)
Vein thrombosis
Nausea

Storage Conditions:

Store at temperatures between 5°C and 30°C. Do not freeze. Keep out of reach of children.

Important Note: This information is intended for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before using any medication or treatment.

For more information on Glucose solution for infusion 50mg/ml, please contact a healthcare professional.