Naklofen Duo long-acting capsules 75mg №10×2

Side effects are classified into appropriate groups depending on the frequency of occurrence: very often (≥1/10), often (≥1/100 to <1/10), infrequently (≥1/1000 to <1/100), rare (≥ 1/10, 000 to <1/1000), very rare (<1/10, 000), frequency unknown (cannot be estimated from available data). The most commonly observed side effects are from the gastrointestinal tract. Possible, especially in elderly patients, peptic ulcer, perforation or gastrointestinal bleeding, incl. with a lethal outcome. On the part of the hematopoietic system: very rarely – thrombocytopenia, leukopenia, agranulocytosis, anemia (including hemolytic and aplastic). From the immune system: rarely – hypersensitivity reactions, anaphylactic and anaphylactoid reactions (including bronchospasm, hypotension and shock); very rarely – angioedema (including swelling of the face). Mental disorders: very rarely – disorientation, depression, insomnia, nightmares, irritability, psychotic disorders. From the nervous system: often – headache, dizziness; rarely – drowsiness; very rarely – paresthesia, memory impairment, convulsions, anxiety, tremor, aseptic meningitis, taste disorders, cerebrovascular accident. On the part of the organ of vision: very rarely – blurred vision, blurred vision, diplopia. On the part of the organ of hearing and the labyrinth system: often – vertigo; very rarely – tinnitus, hearing loss. From the side of the cardiovascular system: infrequently – * palpitations, chest pain, heart failure, myocardial infarction; very rarely – hypertension, vasculitis. From the respiratory system: rarely – asthma (including shortness of breath); very rarely – pneumonitis. From the digestive system: often – nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, loss of appetite; rarely – gastritis, gastrointestinal bleeding, vomiting with blood, melena, hemorrhagic diarrhea, stomach or intestinal ulcers with or without bleeding or perforation, which can lead to peritonitis; very rarely – ischemic colitis (including hemorrhagic, exacerbation of ulcerative colitis or Crohn's disease), constipation, stomatitis, glossitis, esophageal disorders, diaphragm-like intestinal strictures, pancreatitis; frequency unknown – inflammatory conditions in the lower intestine (in the small and large intestine) with the formation of pseudomembranes and strictures. From the hepatobiliary system: often – increased activity of transaminases; rarely – jaundice, hepatitis, impaired liver function; very rarely – fulminant hepatitis, hepatonecrosis, liver failure. From the skin and subcutaneous tissues: often – rash; rarely – urticaria; very rarely – bullous rashes, eczema, erythema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), exfoliative dermatitis, hair loss, photosensitivity reactions, purpura, allergic purpura, itching. From the urinary system: often – fluid retention, edema and arterial hypertension; very rarely – acute renal failure, hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, renal papillary necrosis. Other: rarely – edema. * The frequency reflects the data of long-term therapy using the drug at a high dose (150 mg / day). Clinical studies and data from epidemiological studies indicate that the use of diclofenac increases the risk of thrombotic complications (for example, myocardial infarction or stroke), especially with prolonged use or at high doses (150 mg / day). Visual disturbances Impaired vision, blurred vision, or double vision are common side effects of the NSAID class and are usually reversible upon discontinuation. A possible mechanism of occurrence is inhibition of the synthesis of prostaglandins and other compounds that disrupt the regulation of retinal blood flow, causing possible visual disturbances. If such disorders occur during treatment with diclofenac, an ophthalmological examination should be performed to exclude other possible causes of their occurrence. If severe side effects occur, diclofenac should be discontinued.