Lisoretic pills 10mg/12.5mg №14x2

Lisoretic 10mg/12.5mg №14x2: Effective Hypertension Treatment

Discover Lisoretic, a potent combination of lisinopril and hydrochlorothiazide, designed to effectively manage mild to moderate hypertension. This comprehensive guide will provide you with a detailed understanding of Lisoretic's composition, mechanism of action, dosage, potential side effects, and interactions with other medications.

Key Features:

• Dual-action formula: Combines the blood pressure-lowering benefits of lisinopril (an ACE inhibitor) and hydrochlorothiazide (a thiazide diuretic) for a synergistic effect.
• Convenient once-daily dosing: Requires just one tablet per day for consistent blood pressure control.
• Available in two strengths: Lisoretic 10mg/12.5mg and Lisoretic 20mg/12.5mg, allowing for tailored dosage adjustments.

Composition:

Lisoretic 10mg/12.5mg tablet contains:

• Active ingredients: Lisinopril (as lisinopril dihydrate) 10.00 mg and hydrochlorothiazide 12.50 mg
• Excipients: Calcium hydrogen phosphate 38.01 mg, mannitol 22.00 mg, corn starch 22.40 mg, pregelatinized starch 3.00 mg, iron dye red oxide (E172) 0.05 mg, iron dye yellow oxide (E172) 0.05 mg, magnesium stearate 1.10 mg.

Lisoretic 20mg/12.5mg tablet contains:

• Active ingredients: Lisinopril (as lisinopril dihydrate) 20.00 mg and hydrochlorothiazide 12.50 mg
• Excipients: Calcium hydrogen phosphate 88.72 mg, mannitol 44.00 mg, corn starch 44.80 mg, pregelatinized starch 6.00 mg, magnesium stearate 2.20 mg.

Mechanism of Action:

Lisoretic acts by effectively lowering blood pressure through two complementary mechanisms:

• Lisinopril: Blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to vasodilation and reduced blood pressure.
• Hydrochlorothiazide: Increases urine production by promoting sodium and chloride excretion, further contributing to blood pressure reduction.

Dosage and Administration:

• Typical Dosage: One tablet (10mg/12.5mg or 20mg/12.5mg) daily, taken at the same time each day.
• Dosage Adjustments: Dose can be increased to two tablets daily if necessary, after careful evaluation by your doctor.
• Renal Insufficiency: Use with caution in patients with renal impairment; consult your doctor for appropriate dosage adjustment.
• Elderly Patients: Dosage may need to be adjusted based on individual needs; consult your doctor for personalized recommendations.

Side Effects:

Common side effects include:

• Dizziness
• Headache
• Orthostatic hypotension
• Cough
• Diarrhea

Rare but serious side effects:

• Angioedema
• Hyperkalemia
• Neutropenia
• Renal impairment
• Liver damage
• Allergic reactions

Drug Interactions:

Lisoretic may interact with other medications, including:

• Potassium-sparing diuretics, potassium supplements, and salt substitutes
• Lithium
• Antidiabetic agents
• NSAIDs
• Allopurinol
• Cyclosporine
• Lovastatin
• Trimethoprim
• Sotalol
• Cholestyramine and cholestipol
• Tricyclic antidepressants and antipsychotics
• Drugs that cause pirouette-type heart rhythm disturbances
• Corticosteroids, amphotericin B, carbenoxolone, corticotropin (ACTH), or stimulant laxatives
• Other antihypertensive agents
• Sympathomimetics
• Allopurinol, procainamide, cytotoxic or immunosuppressive agents
• Calcium salts
• Other agents

Precautions:

• Hypotension: May occur, especially after the initial dose.
• Electrolyte imbalances: Can occur, particularly hypokalemia, hyponatremia, and hypochloremia.
• Renal impairment: Use with caution in patients with impaired renal function.
• Liver disease: Use with caution in patients with impaired liver function.
• Surgery/anesthesia: Inform your anesthesiologist about Lisoretic use before surgery.
• Metabolic and endocrine effects: May affect glucose tolerance, cholesterol levels, and triglyceride levels.
• Hypersensitivity/angioneurotic edema: Can occur in rare cases; discontinue use immediately if it develops.
• Anaphylactoid reactions: May occur during desensitization procedures or high-flow dialysis/membrane exposure.
• Serum potassium: Monitor serum potassium levels regularly, especially in patients with kidney dysfunction, diabetes mellitus, or taking potassium-sparing diuretics.
• Cough: A common side effect that typically resolves after discontinuing Lisoretic.
• Neutropenia/agranulocytosis: Monitor blood counts regularly, especially in patients with certain risk factors.
• Proteinuria: May occur, especially in patients with impaired renal function.
• Ethnic differences: May be more likely to cause angioedema in black patients.
• Pregnancy and Lactation: Lisoretic is contraindicated during pregnancy and lactation.

Conclusion:

Lisoretic is a valuable tool for the management of mild to moderate hypertension. It offers a convenient and effective way to lower blood pressure through its dual-action formula. However, it's important to be aware of potential side effects and interactions with other medications. Consult your doctor to determine if Lisoretic is right for you and to ensure safe and effective use.

Please note: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider for any health concerns or before making any decisions related to your health or treatment.