Enfluvir is a potent antiviral medication manufactured in Turkey, available in convenient 10-capsule packs. This prescription drug contains oseltamivir phosphate, a prodrug that converts into the active metabolite oseltamivir carboxylate (OC). OC is a selective inhibitor of neuraminidase, an enzyme crucial for the influenza A and B viruses' replication and spread.
By inhibiting neuraminidase, Enfluvir prevents newly formed virus particles from escaping infected cells. This effectively blocks the virus's ability to infect healthy respiratory epithelial cells, thereby limiting its propagation throughout the body. In vitro studies have shown Enfluvir's effectiveness in inhibiting influenza virus growth, while in vivo studies demonstrate its ability to suppress viral replication and pathogenicity, significantly reducing the shedding of influenza A and B viruses. The concentration of OC required to inhibit neuraminidase by 50% (IC50) is exceptionally low: 0.1-1.3 nM for influenza A and 2.6 nM for influenza B.
The clinical efficacy of Enfluvir has been rigorously demonstrated in both experimental human influenza studies and large-scale Phase III trials involving naturally occurring influenza infections. Notably, Enfluvir does not interfere with the production of influenza antibodies, including those generated in response to influenza vaccinations.
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