Diclofenac-LF solution for injections 75mg/3ml №5×1

Diclofenac-LF Injection: Effective Pain Relief for Rheumatic and Non-Rheumatic Conditions

Looking for fast-acting pain relief for inflammatory conditions? Diclofenac-LF injection is a potent solution for reducing pain and inflammation associated with a range of ailments. This comprehensive guide provides essential information on its benefits, dosage, potential side effects, and important precautions.

What is Diclofenac-LF?

Diclofenac-LF is a non-steroidal anti-inflammatory drug (NSAID) available as a solution for injection. It contains the active ingredient diclofenac sodium, known for its powerful anti-inflammatory, analgesic, and antipyretic (fever-reducing) properties.

How does Diclofenac-LF work?

Diclofenac-LF works by inhibiting the production of prostaglandins, which play a key role in inflammation, pain, and fever. By reducing prostaglandin levels, Diclofenac-LF effectively alleviates pain and inflammation, promoting improved joint function and overall well-being.

What conditions does Diclofenac-LF treat?

Diclofenac-LF injection is indicated for the treatment of various inflammatory and painful conditions, including:

• Rheumatic Diseases: Rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis, and vertebral pain syndrome.
• Gout: Acute attacks of gout.
• Colic: Renal and hepatic colic.
• Post-Operative Pain: Pain and inflammation following injuries or surgical procedures.
• Migraine: Severe migraine attacks.

How is Diclofenac-LF administered?

Diclofenac-LF is administered by intramuscular injection or intravenous infusion, depending on the severity of the condition and individual patient needs.

• Intramuscular Injection: Typically, one ampoule (75 mg) is administered daily via deep injection into the gluteus maximus muscle. In severe cases, the dose may be increased to two ampoules per day.
• Intravenous Infusion: The solution should be diluted in 100-500 ml of saline or glucose solution and infused over 30 minutes to 2 hours for moderate to severe postoperative pain. For pain prevention, a loading dose may be administered followed by a continuous infusion.

Important Precautions and Potential Side Effects:

While Diclofenac-LF can be effective, it’s crucial to be aware of its potential side effects and take necessary precautions:

• Gastrointestinal Effects: Diclofenac-LF can cause gastrointestinal bleeding, ulceration, or perforation, which can be serious and potentially fatal. Patients with a history of gastrointestinal problems should discuss the risks with their doctor.
• Cardiovascular Effects: There’s a potential increased risk of arterial thrombotic events (e.g., heart attack, stroke) associated with Diclofenac-LF. Patients with cardiovascular risk factors should be closely monitored.
• Hematological Effects: Diclofenac-LF can temporarily inhibit platelet aggregation, which may increase bleeding risk in patients with impaired hemostasis.
• Hepatic Effects: Diclofenac-LF can cause liver problems, especially in patients with pre-existing liver disease. Liver function should be monitored regularly during treatment.
• Renal Effects: Diclofenac-LF can cause fluid retention and worsen renal function. Patients with pre-existing kidney problems should be closely monitored.
• Allergic Reactions: Allergic reactions, including anaphylaxis, can occur with Diclofenac-LF. Seek immediate medical attention if you experience any allergic reactions.

Who should not use Diclofenac-LF?

Diclofenac-LF is contraindicated in several situations, including:

• Hypersensitivity: Allergy to diclofenac, sodium metabisulphite, or any other component of the drug.
• Asthma: Patients with aspirin-sensitive asthma.
• Active Ulcers: Active gastric or intestinal ulcers, bleeding, or perforation.
• Inflammatory Bowel Disease: Crohn’s disease or ulcerative colitis.
• Liver Failure: Severe liver disease.
• Renal Failure: Severe kidney disease.
• Heart Failure: Established congestive heart failure.
• Pregnancy: Third trimester of pregnancy.

Important Considerations:

• Dosage Adjustment: Dosage may need to be adjusted for elderly patients, patients with impaired renal or hepatic function, and those with specific medical conditions.
• Concomitant Medications: Diclofenac-LF can interact with other medications, including anticoagulants, antiplatelet agents, diuretics, and antihypertensive drugs. It’s crucial to inform your doctor about all medications you are taking.
• Driving: Diclofenac-LF may cause dizziness, drowsiness, or visual disturbances. Avoid driving or operating machinery if you experience these side effects.
• Pregnancy and Breastfeeding: Diclofenac-LF is not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.

Conclusion:

Diclofenac-LF injection can be an effective treatment option for a range of inflammatory and painful conditions. However, it’s crucial to understand its potential risks and take necessary precautions to ensure safe and effective use. Always consult with your doctor or pharmacist before taking any new medication, including Diclofenac-LF, and follow their instructions carefully.