Miconazole cream 20mg/g 15g №1

Name:
Miconazole cream dnar.prim.20mg in tubes 15g in pack №1
Description:
Cream of white color, homogeneous consistency. The main active ingredient Miconazole Release form cream for external use Dosage 2% 15 g Pharmacological action Pharmacodynamics Miconazole is an antifungal agent from the group of imidazole derivatives, active against most pathogenic fungi and yeasts. The mechanism of action is associated with a change in the permeability of cell membranes due to the suppression of ergosterol biosynthesis, changes in the lipid composition of membranes, and an inhibitory effect on the activity of oxidases and peroxidases. The accumulation of ergosterol precursors and toxic peroxides leads to the death of the fungal cell. The clinical efficacy of miconazole has been demonstrated against the following species: Dermatophytes, Candida spp., Dimorphic fungi, Aspergillus spp., Cryptococcus neoformans, Pityrosporum spp., Torulopsis glabrata. Miconazole also has antibacterial activity against certain Gram-positive bacteria. Pharmacokinetics After topical application, miconazole is almost not subject to systemic absorption. A small amount that is absorbed (less than 1%) binds to plasma proteins (88.2%) and erythrocytes (10.6%). Excreted from the body mainly through the intestines unchanged and in the form of metabolites. Indications for use Fungal infections of the skin and nails caused by dermatophytes or yeasts susceptible to miconazole. Superinfections caused by Gram-positive bacteria. Dosage and administration The cream is lightly rubbed into the affected areas of the skin 2 times a day, in the morning and in the evening. Depending on the localization and severity of the process, the duration of treatment varies from 2 to 6 weeks. In order to prevent relapses, the use of the drug must be continued for at least 1 week after the disappearance of the clinical symptoms of the disease. During therapy, mycological control is carried out, the results of which determine the duration of treatment. In the treatment of onychomycosis, after preliminary exfoliation of the affected nail plate, the cream is applied to the nail bed 1-2 times a day. Treatment is carried out continuously and continues for at least 10 days after the disappearance of clinical symptoms. With caution For children under 3 years of age, the cream is prescribed under the supervision of a doctor. Use during pregnancy and lactation Pregnancy In animals, miconazole nitrate does not show teratogenic effects, but is fetotoxic when taken orally in high doses. Only a small amount of miconazole nitrate is absorbed when applied topically. However, like other imidazoles, miconazole nitrate should be used with caution during pregnancy. Lactation When applied topically, miconazole is minimally absorbed into the systemic circulation, and it is not known whether miconazole passes into breast milk. Caution should be exercised in the topical application of miconazole during lactation. Do not apply the drug to the mammary glands during breastfeeding. Precautions Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported during treatment with topical forms of miconazole. If hypersensitivity reactions occur during treatment, the drug should be discontinued. Do not allow the cream to get into the eyes. Do not apply cream to open wounds. If the nails are damaged, they should be cut as short as possible. In case of damage to the feet, carefully treat the interdigital spaces. The medicinal product contains propylene glycol and cetostearyl alcohol, therefore it may cause skin irritation, local skin reactions (for example, contact dermatitis). Interaction with other drugs Miconazole is an inhibitor of cytochrome CYP3A4/2C9. Due to limited systemic availability when applied topically, clinically significant interactions are unlikely. However, in patients receiving oral anticoagulants (eg warfarin), care should be taken to monitor the anticoagulant effect. With the simultaneous use of oral hypoglycemic agents and phenytoin with miconazole, it is possible to increase the effects, including undesirable ones. It is not recommended to use simultaneously with other ointments or creams. Contraindications Hypersensitivity to miconazole or to any of the auxiliary components of the drug. Composition Each tube (15 g) contains: active ingredient: miconazole nitrate – 0.3 g; excipients: propylene glycol, macrogol 400, cetostearyl alcohol, emuxol 268 brand A, macrogol cetostearyl ether. Overdose Excessive topical application of the cream can lead to skin irritation, which usually disappears after application is discontinued. The cream is intended for external use. In case of accidental ingestion of a large amount of cream, if necessary, an appropriate method of emptying the stomach can be applied. Side effects The development of the following adverse reactions is possible: From the side of the immune system: hypersensitivity reactions, including anaphylactic reactions, angioedema. On the part of the skin and subcutaneous tissue: rash, itching, erythema, urticaria, skin inflammation, contact dermatitis, skin hypopigmentation, reactions at the application site, including skin irritation, hyperemia, burning. Storage conditions At a temperature not higher than 25 °C. Keep out of the reach of children. Buy Miconazole cream 20mg/g 15g №1 Price for Miconazole cream 20mg/g 15g №1 Instructions for use for Miconazole cream 20mg/g 15g №1