Mekol ointment 40g №1

Name:
Mekol ointment dnar.prim.in tubes 40g in pack No. 1 Composition Each tube (40 g) contains: active ingredients: chloramphenicol – 0.30 g, methyluracil – 1.60 g; excipients: macrogol 1500, macrogol 400.
Description:
Ointment white or white with a yellowish tint, uniform consistency. Pharmacotherapeutic group Antibiotics for local use. ATX code: D06AX. Pharmacological properties Pharmacodynamics Combined preparation for topical application with antimicrobial, reparative and anti-inflammatory action. Chloramphenicol (levomycetin), which is part of the drug, has an antimicrobial effect, the mechanism of which is associated with a violation of the synthesis of proteins of microorganisms. It acts bacteriostatically, is active against gram-positive and gram-negative microorganisms (staphylococcus aureus, streptococcus, Pseudomonas aeruginosa and Escherichia coli). Methyluracil accelerates the processes of cell regeneration, promotes scarring of wounds and has an anti-inflammatory effect. The drug easily penetrates tissues without damaging biological membranes, however, the degree of systemic absorption after application of the drug to the skin, wounds and mucous membranes is unknown. Pharmacokinetics Pharmacokinetics have not been studied. Indications for use Purulent wounds (including those infected with mixed microflora) in the first (purulent-necrotic) phase of the wound process. Contraindications Hypersensitivity to the components of the drug, psoriasis, eczema, fungal skin lesions, malignant neoplasms of the skin, a history of pathology of the blood system, including myelosuppression and aplastic anemia, children under 3 years of age. Dosage and administration The drug is intended for external use in adults and children over 3 years of age. Soak sterile gauze pads with ointment, which should be used to fill the wound. It is possible to introduce ointment into purulent cavities through a catheter (drainage tube) using a syringe. In such cases, preheat the ointment to 35-36 ° C. Dressings should be performed daily until the wound is completely cleansed of purulent-necrotic masses and until their granulation begins. With a large area of wound surfaces, the daily dose of ointment in terms of chloramphenicol (levomycetin) should not exceed 3 g. The duration of treatment depends on the severity and characteristics of the course of the disease. Do not use the ointment for more than 5 days without a doctor’s prescription. Precautions The use of topical antibacterial agents can lead to skin sensitization, accompanied by the development of hypersensitivity reactions with further use of this drug externally or in the form of a systemic dosage form. In the presence of pus or necrotic masses, the antibacterial effect of the drug is preserved. Do not allow the ointment to get on the mucous membrane of the eyes. If it is necessary to continue therapy for more than 5 days, it is recommended to re-evaluate the local status and general condition of the patient. After topical application of chloramphenicol, its systemic absorption is possible, which, with prolonged exposure, can lead to toxicity. Bone marrow hypoplasia, including aplastic anemia, has been reported following topical application of chloramphenicol. Although the risk is low, it should be taken into account when evaluating the benefits expected from treatment. With prolonged use of the drug, it is necessary to monitor the state of peripheral blood. Pregnancy and lactation Use during pregnancy and lactation is contraindicated. Influence on the ability to drive vehicles and work with mechanisms Does not affect. Side effects Local reactions: irritant, contact dermatitis. On the part of the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, reticolocytopenia, aplastic anemia. Allergic reactions: skin rash, urticaria, itching, burning, angioedema. Interaction with other drugs Simultaneous use with drugs that inhibit hematopoiesis (sulfonamides, cytostatics, pyrazoline derivatives) is undesirable. The drug is incompatible with barbiturates, alcohol. Overdose No cases of overdose have been reported. With prolonged and frequent use of the ointment, the described adverse reactions may appear and increase. In this case, you should stop using the ointment and consult a doctor. Treatment is symptomatic. Release form 40 g in aluminum tubes. Each tube, together with the leaflet, is placed in a cardboard box (packaging No. 1). Storage At a temperature not higher than 20? Keep out of the reach of children. Shelf life 3.5 years. Do not use the medicine after the expiration date indicated on the package. Terms of dispensing from pharmaciesWithout a prescription. Buy Mekol ointment 40g №1 Price for Mekol ointment 40g №1Instruction for use for Mekol ointment 40g №1