Fluconazole Pharmland capsules 150mg №1×1

Name Fluconazole Pharmland caps. The main active substance Fluconazole Release form capsules Dosage 150 mg. Indications for use Each capsule of Fluconazole contains the active substance – fluconazole, 50 mg or 150 mg, and excipients: lactose, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, talc. Fluconazole is a systemic antifungal drug. It is used to treat or prevent infections caused by fungi. ATC code J02AC01. Treatment in adults of diseases caused by fungal microflora: vaginal candidiasis (acute, recurrent), candidal balanitis (when topical therapy is not suitable), mucosal candidiasis (including oropharyngeal candidiasis, esophageal candidiasis, candiduria, chronic candidiasis of the skin and mucous membranes), chronic oral atrophic candidiasis (candidiasis caused by dentures if oral hygiene or topical treatment is insufficient), ringworm (including athlete’s foot, athlete’s foot, ringworm inguinal, versicolor and candidal skin infections when systemic therapy is not appropriate), dermatophyte onychomycosis (when the use of other drugs is not appropriate). cryptococcal meningitis, coccidioidomycosis, invasive candidiasis. Prophylaxis in adults in the following cases: recurrent vaginal candidiasis (4 or more episodes per year) – to reduce the frequency of relapses, high risk of recurrence of cryptococcal meningitis, high risk of recurrence of oropharyngeal or esophageal candidiasis in patients with HIV, prevention of candidiasis in patients with prolonged neutropenia. Prevention and treatment of candidiasis in children: treatment of candidiasis of the mucous membranes (oropharynx, esophagus), invasive candidiasis, cryptococcal meningitis; prevention of candidal infections in patients with reduced immunity, prevention of recurrence of cryptococcal meningitis in children with a high risk of its development. Dosage and administration The capsule is swallowed whole with a glass of water. It is advisable to take the capsules daily at the same time in the dose prescribed by the doctor. Adults: Treatment of cryptococcal meningitis: 400 mg on the first day, then from 200 mg to 400 mg once daily for 6 to 8 weeks or more as needed. The dose may be increased up to 800 mg. Prevention of recurrence of cryptococcal meningitis: 200 mg once a day for a long time. Treatment of coccidioidomycosis: 200 mg – 400 mg once a day, 11 – 24 months or more if necessary. The dose may be increased to 800 mg. Treatment of internal candidal infections: 800 mg on the first day, then 400 mg once a day for a long time. Treatment of candidal infections of the mucous membrane of the mouth, throat (including from wearing dentures): 200 mg – 400 mg on the first day, then 100 mg – 200 mg, until the symptoms disappear completely. Treatment of candidal stomatitis: the dose depends on the localization of the infection: 50 mg – 400 mg once a day, 7 – 30 days until the symptoms disappear completely. Prevention of recurrence of infections of the mucous membranes of the mouth, throat: 100 mg – 200 mg once a day or 200 mg 3 times a week until the risk of infection disappears. Treatment of vaginal candidiasis: 150 mg once Prevention of recurrence of vaginal candidiasis: 150 mg every three days, 3 doses (days 1, 4 and 7), then once a week for 6 months until the risk of infection disappears. Treatment of fungal infections of the skin and nails: the dose depends on the location of the infection: 50 mg once a day, 150 mg – 400 mg once a week for 1 to 4 weeks (foot mycosis – up to 6 weeks, with damage to the nails – before replacing the infected nail). Prevention of fungal infections in immunocompromised patients: 200 mg – 400 mg once a day until the risk of infection disappears Use in adolescents from 12 to 17 years: In most cases, the dosages correspond to those of adults. Use in children under 11 years of age: The maximum dose for children is 400 mg per day. Treatment of candidal infections of the mucous membrane of the mouth, throat: the dose and duration depend on the severity of the infection and on the place of its localization: 6 mg / kg of body weight on the first day, the subsequent dose is 3 mg / kg. Cryptococcal meningitis or internal candidal infections: 6 mg – 12 mg/kg body weight. Prevention of candidal infections in children with reduced immunity: 6 mg – 12 mg / kg of body weight. Elderly patients: With normal renal function, dose adjustment is not required. Patients with impaired renal function: With a single dose, dose adjustment is not needed. With multiple doses, on the first day of treatment, take 50 mg – 400 mg, depending on the indications. With creatinine clearance? 50 ml / min – 50% of the indicated dose. Patients on regular dialysis should receive 100% of the recommended dose after each dialysis. On the day when dialysis is not carried out, the dose is adjusted depending on the creatinine clearance. Use of fluconazole in children: Use of the drug in the form of capsules is possible in cases where children are able to safely swallow the capsule (usually over the age of 5 years). If it is necessary to take fluconazole in young children, it is necessary to prescribe a dosage form more suitable for children. Use during pregnancy and lactation Use of Fluconazole during pregnancy and lactation: Contraindicated. Precautions Precautions and precautions when taking Fluconazole: Dermatophytosis. Fluconazole is not used to treat this pathology due to low efficiency. Cryptococcosis, deep endemic mycoses. Evidence of the effectiveness of fluconazole for these diseases is insufficient, and therefore there are no dosage recommendations. hepatobiliary system. It is used with caution in violation of liver function. In rare cases, it is possible to develop severe hepatotoxicity, including deaths, against the background of a serious underlying disease. Usually, hepatotoxicity caused by fluconazole is reversible, and its manifestations disappear after cessation of therapy. Monitoring of liver function is recommended. If symptoms of asthenia, anorexia, persistent nausea, vomiting, jaundice appear, the drug should be discontinued. The cardiovascular system. Very rare cases of QT interval prolongation and torsades de pointes have been reported in patients with severe comorbidities with a combination of many risk factors (structural heart disease, electrolyte disturbances, concomitant use of drugs that affect the QT interval). It is used with caution in patients at risk of developing arrhythmias. Skin reactions. Fluconazole rarely causes severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis). HIV-positive patients are more likely to develop such reactions with many drugs. With the appearance of rashes associated with taking Fluconazole in this group of patients, the drug should be discontinued. It is recommended to monitor the patient’s condition. Excipients. Fluconazole is not taken in cases of congenital galactose intolerance and Lapp lactase deficiency or malabsorption of glucose and galactose (contains lactose). Interaction with other drugs When prescribing Fluconazole, be sure to inform your doctor if you are taking any of the following drugs: Rifampicin, rifabutin – antibacterial drugs for the treatment of tuberculosis; Azithromycin – an antibacterial agent for the treatment of infections; Alfentanil, fentanyl – drugs for general anesthesia; Amitriptyline, nortriptyline – antidepressants; Amphotericin B, voriconazole – antifungal drugs; Medicines that reduce blood clotting and prevent the formation of blood clots (anticoagulants, including warfarin); Benzodiazepines (midazolam, triazolam, etc.) – tranquilizers for the treatment of sleep disorders, anxiety; Carbamazepine, phenytoin – anticonvulsants; Nifedipine, isradipine, amlodipine, felodipine, losartan – drugs for the treatment of hypertension; Cyclosporine, everolimus, sirolimus, tacrolimus – means to prevent transplant rejection; Cyclophosphamide, vinca alkaloids (vincristine, vinblastine or similar drugs) – antitumor agents; Statins (atorvastatin, simvastatin and fluvastatin or similar drugs) – drugs to lower cholesterol; Methadone – a drug for pain relief and treatment of drug addiction; Celecoxib, flurbiprofen, naproxen, ibuprofen, lornoxicam, meloxicam, diclofenac – non-steroidal anti-inflammatory drugs (NSAIDs); oral contraceptives; Prednisolone is a synthetic glucocorticoid hormone; Zidovudine, saquinavir – drugs for the treatment of HIV infection; Antidiabetic agents (chlorpropamide, glibenclamide, glipizide, tolbutamide); Theophylline – a means for dilating the bronchi with difficulty breathing; Vitamin A – food supplement; Contraindications Hypersensitivity to fluconazole, other azole compounds or any of the excipients. Simultaneous use of fluconazole and terfenadine, with multiple doses of fluconazole in a daily dose of more than 400 mg. Simultaneous use of fluconazole and other drugs (cisapride, astemizole, pimozide, quinidine, erythromycin, etc.) that prolong the QT interval on the ECG and are metabolized by the CYP2A4 enzyme. The combination of fluconazole and halofantrine (a treatment for malaria) is not recommended. Composition Each capsule of Fluconazole contains the active substance – fluconazole, 50 mg or 150 mg, and excipients: lactose, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, talc. Fluconazole is a systemic antifungal drug. Overdose If the number of tablets per day that you have taken exceeds the amount recommended by your doctor, or your child has swallowed the tablets, consult a doctor or call an ambulance! Stop taking the medicine! Overdose can be manifested by auditory, visual and sensory hallucinations (hallucinations and paranoid behavior). As a first aid, gastric lavage. Side effectsPossible side effects: Like all medicines, fluconazole can cause side effects with varying frequency. Common (1 in 10 – 100 cases): headache, abdominal pain, diarrhea, nausea, vomiting, rash, elevated blood levels of liver enzymes (ALT, AST, alkaline phosphatase) Uncommon (1 in 100 – 1,000 cases) : anemia, loss of appetite, insomnia, drowsiness, convulsions, dizziness, paresthesia, taste disturbances, vertigo, constipation, dyspepsia, flatulence, dry mouth, cholestasis, jaundice, increased bilirubin, itching, drug-induced dermatitis, urticaria, increased sweating, pain in the muscles, fatigue, malaise, asthenia, fever. Rare (1 in 1,000 to 10,000 cases): Decreased blood cell count, anaphylaxis, elevated blood lipids and cholesterol, decreased blood potassium, tremor, torsades de pointes, QT prolongation on ECG, liver failure , necrosis, hepatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, exfoliative dermatitis, facial edema, alopecia Keep out of the reach of children. Buy Fluconazole Farmland capsules 150mg №1×1 Price for Fluconazole Farmland capsules 150mg №1×1