Name:
Clotrimazole cream 1% in tubes 20g in pack №1
Description:
Cream for external use Homogeneous cream from white to yellowish color. The main active ingredient Clotrimazole Release form cream Dosage 20 g Special instructions Avoid getting the cream on the mucous membrane of the eyes. Avoid application on areas with violation of the integrity of the skin. The excipient nipagin may cause allergic reactions. The cetyl alcohol content may cause local skin reactions. The appearance of irritation or signs of hypersensitivity requires discontinuation of treatment. There is no data that would prove the negative effect of the drug on pregnancy. It is not recommended to use the drug in the first trimester of pregnancy. The question of the advisability of using the drug in the II and III trimesters of pregnancy should be decided individually. Caution should be exercised when using the drug during lactation. Applying the cream directly to the mammary gland during lactation is not recommended. Does not affect the patient’s ability to perform work that requires increased attention and speed of psychomotor reactions. When applying the cream in the genital area, the integrity of latex products, such as condoms and vaginal diaphragms, may be damaged. Pharmacological action Antifungal drugs for the treatment of skin diseases. imidazole derivatives. Pharmacodynamics Clotrimazole inhibits the synthesis of ergosterol, which leads to structural and functional changes in the cytoplasmic membrane of fungi. In vitro and in vivo studies have shown that clotrimazole has a broad spectrum of activity against dermatophytes, yeasts, molds and dimorphic fungi. In experimental studies, the minimum concentrations that inhibit the development of fungi were 0.062-8 mg / l. Clotrimazole has a fungistatic, and with respect to dermatophytes and some fungi of the genus, a fungicidal effect. In addition, in in vitro studies, clotrimazole exhibits antibacterial properties against some gram-positive (Streptococcus spp., Staphylococcus spp., Gardnerella vaginalis) and gram-negative microorganisms (Bacteroides spp.). In vitro studies have shown that clotrimazole inhibits the proliferation of measles, non-bacteria and some gram-positive cocci, with the exception of enterococci, at minimum inhibitory concentrations of 0.5 to 10 mg / l. Among strains of fungi sensitive to clotrimazole, primary resistance is assessed as low. Pharmacokinetics Clotrimazole is minimally absorbed through intact skin and mucous membranes. As a result, the peak serum concentration of clotrimazole was below the detection limit of 0.001 µg/mL. Topical application of clotrimazole is expected to be unlikely to result in measurable systemic or adverse effects. Clotrimazole accumulates in the stratum corneum of the epidermis, penetrates into the keratin of the nails. Clotrimazole with external use has practically no systemic effect. Indications for use Damage to the skin and mucous membranes caused by dermatophytes, molds, yeasts, as well as Malassezia furfur, Corynebacterium minutissimum. fungal infections of the skin and skin folds; superficial candidiasis; fungal infections of the legs (athlete’s feet), interdigital mycosis of the fingers and toes; damage to the nail fold (paronychia), combined with onychomycosis; fungal (including candidal) superinfections in skin diseases; infections caused by Corynebacterium minutissimum (erythrasma); candidal vulvitis; candidal balanitis. Dosage and administration Externally. The drug is applied in a thin layer on pre-washed and dry affected areas of the skin 2-3 times / day. A single dose based on a surface area the size of a palm is – a column of cream 5 mm long. With candidal vulvitis or balanitis, use 1-3 times a day for 1-2 weeks. Before lubrication, the feet are washed with warm water and soap, thoroughly wiped, especially between the toes. The duration of treatment is set individually depending on the severity and course of the disease, the localization of pathological changes, the effectiveness of therapy. Usually treatment with the drug is carried out for at least 4 weeks. Therapy is recommended to continue for 2 weeks after the disappearance of the clinical symptoms of the disease. Duration of treatment: ringworm – 3-4 weeks; erythrasma – 2-4 weeks; pityriasis versicolor – 1-3 weeks; candidal vulvitis or balanitis – 1-2 weeks. a change in the dosage of the drug is required. Application during pregnancy and lactation Despite the low absorption of the drug and the lack of data on the penetration of clotrimazole through the placenta and into breast milk, when applied externally during pregnancy and lactation, the drug should be used with caution and only if the doctor considers that the benefit of using the drug exceeds potential risk to the fetus or child. Interaction with other drugs When used simultaneously with nystatin, the activity of the drug may decrease. Contraindications Hypersensitivity to clotrimazole and other components of the drug. Composition Active substance: clotrimazole – 10 mg / g; excipients: cetyl alcohol, petroleum jelly, glycerin, polysorbate 80, nipagin, purified water. Overdose With external use of the drug, an overdose is unlikely. The use of clotrimazole in high doses does not cause any reactions and conditions that are life-threatening. The drug is not intended for oral administration. If by chance the cream is taken orally, anorexia, nausea, vomiting, abdominal pain, liver dysfunction are possible; rarely drowsiness, hallucinations, frequent urination, allergic skin reactions. In this case, it is necessary to carry out a gastric lavage and prescribe activated charcoal. Side effects From the immune system: allergic reactions (urticaria, arterial hypotension, shortness of breath, fainting). On the part of the skin: burning sensation and tingling, itching, irritation at the site of application of the drug, blistering, swelling, peeling of the skin, rash, soreness, discomfort. Based on the available information, the frequency of adverse reactions cannot be estimated. In case of side effects, it is necessary to wash the skin with soap and warm water and stop treatment. Storage conditionsStore at a temperature not exceeding 25 °C. Do not freeze. Buy Clotrimazole cream 1% 20g №1 Price for Clotrimazole cream 1% 20g №1 Instructions for use for Clotrimazole cream 1% 20g №1
INN | clotrimazole |
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The code | 1 031 |
Barcode | 5 944 709 000 013 |
Dosage | 1% 20g |
Active substance | clotrimazole |
Manufacturer | Hyperion K.O. AO, Romania |
Importer | Limited Liability Company "VitPharmMarket", 210004 Vitebsk, 5th Cooperative St., 8; Limited Liability Company "PHARMPROEKT", 220037, Minsk, 1st Solid Lane, 7, room 107; Limited Liability Company "COMFARM", 220131 Minsk, Sosnovy Bor st., 4, office 1 |
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