Mezim forte 10,000 enteric-coated tablets №10×2

Name:
Mezim forte 10000.
Description:
Enteric-coated tablets of pink color, round, with biconvex surfaces, with chamfers; brown blotches are possible at the break. The main active ingredient Pancreatin Release form Tablets, enteric-coated pink, round, with biconvex surfaces, with chamfers; brown blotches are possible at the break. 1 tab. Active substance: pancreatin 137.5 mg; with minimal enzymatic activity: lipases 10,000 IU Ph.Eur; amylase 7500 IU Ph.Eur; proteases 375 IU Ph.Eur; Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate. Shell composition: hypromellose, copolymer of methacrylic acid and ethyl acrylate (1:1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E171), talc, simethicone emulsion 30% (dry weight), macrogol 6000, carmellose sodium, polysorbate 80 , azorubine varnish (E122), sodium hydroxide. 10 pieces. – blisters (1) – packs of cardboard. 10 pieces. – blisters (2) – packs of cardboard. In case of acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of exacerbation attenuation), during restorative dietary nutrition, it is advisable to prescribe Mezim® forte 10000 against the background of ongoing or remaining pancreatic insufficiency. Mezim® forte 10000, taking into account the solid indivisible dosage form, is contraindicated in children under 3 years of age. The effect of the drug on the ability to drive vehicles and control mechanisms Mezim® forte 10000 does not affect the speed of psychomotor reactions and the ability to perceive or assess the situation. Pharmacological action Enzyme preparation that improves digestion. Pancreatin is a powder from porcine pancreas, which, along with exocrine pancreatic enzymes – lipase, amylase, protease, trypsin and chymotrypsin, also contains other enzymes. Pancreatic enzymes, which are part of the drug, facilitate the breakdown of proteins, fats and carbohydrates, which leads to their more complete absorption in the small intestine. Trypsin suppresses stimulated secretion of the pancreas, providing an analgesic effect. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration. Pharmacokinetics Mezim® forte 10000 tablets are coated with an acid-resistant coating that does not dissolve under the action of gastric hydrochloric acid and thereby protects the enzymes contained in the preparation from inactivation. The dissolution of the shell and the release of enzymes occurs at a pH value close to neutral or slightly alkaline. Indications for use Replacement therapy for exocrine pancreatic insufficiency (including chronic pancreatitis, cystic fibrosis); chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder; conditions after resection or irradiation of the gastrointestinal tract, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy); disorder of the gastrointestinal tract of a functional nature (in case of intestinal infectious diseases, irritable bowel syndrome, etc.); to improve the digestion of food in patients with normal gastrointestinal function in case of nutritional errors; preparation for x-ray and ultrasound examinations of the abdominal organs. Method of application and doses The dose of the drug Mezim® forte 10000 is set individually depending on the severity of the disease and the composition of the food. Unless otherwise indicated, the average single dose for adults is 2-4 tab. Mezim® forte 10000 for a meal. It is recommended to take half or a third of a single dose at the beginning of a meal, and the rest during it. The drug is taken orally, without chewing and drinking a sufficient amount of liquid. It is possible to increase the dose, which should be carried out only under the supervision of a physician, focusing on the weakening of symptoms (for example, steatorrhea, abdominal pain). The maximum daily dose is 15000-20000 IU Ph.Eur. lipase/kg body weight. For children, the doctor sets the dosage regimen depending on the severity of the disease and the composition of the food at the rate of 500-1000 IU Ph.Eur. lipase/kg body weight of the child at each meal. The duration of treatment can vary from several days (in case of indigestion, errors in the diet) to several months and even years (if permanent replacement therapy is necessary). Use during pregnancy and lactation Due to the lack of sufficient data on the use of pancreatic enzymes in humans during pregnancy and lactation, the use of Mezim® forte 10000 is possible only if the expected benefit to the mother outweighs the possible risk to the fetus or child. Precautions Contraindicated in children under 3 years of age (indivisible dosage form). For children, the doctor sets the dosage regimen depending on the severity of the disease and the composition of the food at the rate of 500-1000 IU Ph.Eur. lipase/kg body weight of the child at each meal. Interaction with other drugs When taking drugs containing pancreatin, it is possible to reduce the absorption of folic acid. The effect of hypoglycemic drugs (acarbose, miglitol) may decrease when taken simultaneously with pancreatin. With the simultaneous use of pancreatin with iron preparations, a decrease in the absorption of the latter is possible. The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide may lead to a decrease in the effectiveness of the drug. Contraindications Acute pancreatitis; exacerbation of chronic pancreatitis; hypersensitivity to pancreatin or other components of the drug; hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome; children’s age up to 3 years (indivisible dosage form). Composition Active substance: pancreatin 137.5 mg; with minimal enzymatic activity: lipases 10,000 IU Ph.Eur; amylase 7500 IU Ph.Eur; proteases 375 IU Ph.Eur; Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate. Shell composition: hypromellose, copolymer of methacrylic acid and ethyl acrylate (1:1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E171), talc, simethicone emulsion 30% (dry weight), macrogol 6000, carmellose sodium, polysorbate 80 , azorubine varnish (E122), sodium hydroxide. Overdose There are no data on cases of overdose and intoxication with the drug. Possible: hyperuricosuria. hyperuricemia, in children – constipation. Treatment: drug withdrawal, symptomatic therapy. Side effects No development of side effects or complications was detected even with prolonged and regular use of the drug Mezim ® forte 10000 in patients with impaired pancreatic function. In some cases, after taking pancreatin, the development of allergic reactions is possible; rarely – diarrhea or constipation, nausea, discomfort in the epigastric region. In isolated cases, in patients suffering from cystic fibrosis, with prolonged use of high doses of the drug, hyperuricosuria may develop (an increase in the level of uric acid in the blood plasma), strictures may form in the ileocecal region and the ascending colon. Storage conditions The drug should be stored out of the reach of children at a temperature not exceeding 30°C. Buy Mezim forte 10,000 enteric-coated tablets No. 10×2 Price for Mezim forte 10,000 enteric-coated tablets No. 10×2