Magnesium sulfate powder for oral solution 20g in sachets

Name:
Magnesium sulfate powder for solution preparation.
Description:
Colorless prismatic crystals that weather in the air. The main active ingredient is magnesium sulfate. Release formPowder. Pharmacological action When taken orally, it has a choleretic effect (a reflex effect on the receptors of the duodenal mucosa) and a laxative effect (due to poor absorption of the drug in the intestine, a high osmotic pressure is created in it, water accumulates in the intestine, the intestinal contents liquefy, peristalsis increases) . It is an antidote for poisoning with salts of heavy metals. The onset of the effect is after 0.5-3 hours, the duration is 4-6 hours. Indications for use Occasionally used as a laxative for constipation, to prepare for studies of the large intestine and for poisoning with soluble barium salts. Method of administration and dosesInwardly prescribed as a laxative (at night or on an empty stomach – half an hour before meals) for adults, dissolve 10-30 g of powder in 100 ml of warm boiled water, for children over 12 years old – 10 g in 100 ml of warm boiled water, for children 6-12 years old appoint from 5 g to 10 g, dissolved in warm boiled water at the rate of 10 g of magnesium sulfate per 100 ml of water. For chronic constipation – enemas (20-30 g of powder dissolved in 100 ml of warm boiled water). As a choleretic agent, 1 tablespoon of the solution is prescribed (20 g of the powder is dissolved in 100 ml of warm boiled water) 3 times a day; duodenal sounding is also performed with the introduction of a warm solution of magnesium sulfate through the probe (50 ml of a 25% solution or 100 ml of a 10% solution). In case of poisoning with salts of heavy metals, the stomach is washed with a 1% solution of magnesium sulfate or given orally (20-25 g in 200 ml of water). The maximum dose for adults is up to 40 g / day. Do not use higher doses of magnesium sulfate than those recommended in the package leaflet or by your healthcare professional. Use during pregnancy and lactation The drug is contraindicated during pregnancy. During breastfeeding, take under medical supervision if the benefit to the mother outweighs the risk to the baby. Influence on the ability to drive vehicles and other potentially dangerous mechanisms Does not affect. Precautions The drug should be taken occasionally. Systematic use is not recommended. If there is no bowel movement after taking the medicine, you should consult a doctor. Children. Experience in children is limited. Talk to your doctor before taking this medicine if you have diabetes, kidney disease, an eating disorder (anorexia or bulimia), or if you have been taking a laxative for a week. Interaction with other drugs Reduces the effect of oral anticoagulants (including coumarin derivatives or indandione derivatives), cardiac glycosides, phenothiazines (especially chlorpromazine). Reduces the absorption of ciprofloxacin, etidronic acid, antibiotics of the tetracycline group, weakens the effect of streptomycin and tobramycin (magnesium-containing laxative drugs should be taken 1-2 hours after the use of the above drugs). Pharmaceutically incompatible (precipitates) with calcium preparations, ethanol (in high concentrations), alkali metal carbonates, bicarbonates and phosphates, salts of arsenic acid, barium, strontium, clindamycin phosphate, sodium hydrocortisone succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates . Contraindications Hypersensitivity; appendicitis; rectal bleeding (including suspected); intestinal obstruction; acute inflammatory diseases of the gastrointestinal tract; colitis; cholelithiasis; obstruction of the bile ducts; dehydration; hypermagnesemia; conditions associated with calcium deficiency and depression of the respiratory center; acute febrile conditions; arterial hypotension; severe renal failure; pregnancy. Composition Magnesium sulfate – 20 g. Overdose Symptoms: severe diarrhea, vomiting. Treatment: symptomatic. Side effects Nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, electrolyte imbalance (fatigue, asthenia, confusion, arrhythmia, convulsions), flatulence, spastic abdominal pain, thirst, signs of hypermagnesemia in the presence of renal failure (dizziness) . Early signs and symptoms of hypermagnesemia: bradycardia, diplopia, sudden “rush” of blood to the skin of the face, headache, lowering blood pressure, nausea, shortness of breath, blurred speech, vomiting, weakness. Signs of hypermagnesemia (in order of increasing serum Mg2+ concentrations): decreased deep tendon reflexes (2-3.5 mmol/l), prolongation of the PQ interval and expansion of the QRS complex on the ECG (2.5-5 mmol/l), loss of deep tendon reflexes (4-5 mmol/l), depression of the respiratory center (5-6.5 mmol/l), impaired conduction of the heart (7.5 mmol/l), cardiac arrest (12.5 mmol/l). In addition, hyperhidrosis, anxiety, deep sedation, polyuria, uterine atony. In the event of the above adverse reactions or adverse reactions not listed in these instructions for medical use of the drug, you should consult a doctor. Storage conditions Store in a place protected from moisture at a temperature not exceeding 25°C. Keep out of the reach of children. 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