Lopedium tablets 2mg №10×1

Name:
Lopedium tabl 2mg in a blister. in pack. No. 10×1 Storage conditions The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life from the date of manufacture5 years
Description:
of the product Tablets are white or almost white, round, convex on one side, with a score on the other side, the surface of the tablet is beveled to the risk. Pharmacological action Antidiarrheal symptomatic drug. By binding to the opioid receptors of the intestinal wall, loperamide reduces the tone and motility of the smooth muscles of the intestine. Slows down peristalsis and increases the time of passage of intestinal contents. Increases the tone of the anal sphincter. Helps retain feces and reduce the urge to defecate. The action comes on quickly and lasts for 4-6 hours. Pharmacokinetics Absorption Absorption of loperamide is 40%. The time to reach Cmax is 2.5 hours. Distribution Plasma protein binding – 97%. Does not penetrate the BBB. Metabolism Almost completely metabolized in the liver by conjugation. Excretion Excreted mainly in bile and urine. T1 / 2 is 9-14 hours. Indications for use Symptomatic treatment of acute and chronic diarrhea of allergic, emotional, medicinal and radiation genesis; diarrhea with a change in diet, qualitative composition of food, malabsorption and metabolism; as an aid in diarrhea of infectious origin; stool regulation in patients with ileostomy. Use during pregnancy and lactation The drug is contraindicated for use in the first trimester of pregnancy and lactation. Special instructions If there is no effect after 2 days of using Lopedium®, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea. If constipation or bloating develops during treatment, the drug should be discontinued. In patients with impaired liver function, careful monitoring for signs of CNS toxicity is necessary. During the period of treatment, it is necessary to replenish the loss of fluid and electrolytes. Each tablet or capsule of Lopedium® corresponds to 0.01 XE. Influence on the ability to drive vehicles and control mechanisms In case of drowsiness or dizziness, you should refrain from driving vehicles and working with mechanisms. Precautions (Precautions) The drug should be used with caution in patients with hepatic insufficiency. Contraindications Diverticulosis; intestinal obstruction; ulcerative colitis in the acute stage; diarrhea against the background of acute pseudomembranous enterocolitis; as monotherapy for dysentery and other gastrointestinal infections; I trimester of pregnancy; lactation period; children’s age up to 6 years; hypersensitivity to the components of the drug. The drug should be used with caution in patients with hepatic insufficiency. Dosage and administration The drug should be taken orally, tablets and capsules should be swallowed without chewing with 100 ml of water. Adults with acute and chronic diarrhea are prescribed initially 4 mg, then 2 mg after each act of defecation in the case of loose stools. The maximum daily dose is 16 mg. Children over 6 years of age are prescribed 2 mg after each act of defecation in case of loose stools. The maximum daily dose is 6 mg. After normalization of the stool or in the absence of a stool for more than 12 hours, treatment should be discontinued. Overdose Symptoms: CNS depression (stupor, incoordination, drowsiness, miosis, muscle hypertonicity, respiratory depression), intestinal obstruction. Treatment: antidote – naloxone. Since loperamide has a longer duration of action than naloxone, repeated administration of the latter is possible. Carry out symptomatic therapy (activated charcoal, gastric lavage, mechanical ventilation). Medical observation of the patient for at least 48 hours is necessary. Side effects: From the digestive system: gastralgia, dry mouth, nausea, vomiting, intestinal colic, constipation; very rarely – intestinal obstruction. From the side of the central nervous system: drowsiness or insomnia, dizziness, headache. Allergic reactions: skin rash. Composition Active substance: loperamide hydrochloride 2 mg; Excipients: lactose monohydrate – 88.15 mg, calcium hydrophosphate dihydrate – 46 mg, corn starch – 8 mg, sodium starch glycolate – 3.5 mg, colloidal silicon dioxide – 0.6 mg, magnesium stearate – 1.75 mg. Interaction with other drugs Clinically significant interaction of loperamide with other drugs has not been established. Release form Tablets of white or almost white color, round, convex on one side, with a score on the other side, the surface of the tablet is beveled to risk. 1 tab. Active substance: loperamide hydrochloride 2 mg; Excipients: lactose monohydrate – 88.15 mg, calcium hydrophosphate dihydrate – 46 mg, corn starch – 8 mg, sodium starch glycolate – 3.5 mg, colloidal silicon dioxide – 0.6 mg, magnesium stearate – 1.75 mg. 10 pieces. – blisters (1) – cardboard boxes. 10 pieces. – blisters (2) – cardboard boxes. 10 pieces. – blisters (3) – cardboard boxes. 10 pieces. – blisters (5) – cardboard boxes. Buy Lopedium tablets 2mg №10×1 Price for Lopedium tablets 2mg №10×1 Instructions for use for Lopedium tablets 2mg №10×1