Almagel suspension for oral administration in a bottle 170ml №1

Name Almagel susp.d / pr.vn in vial 170ml in pack No. 1 Main active ingredient Algeldrate + magnesium hydroxide Release formSuspension of white or almost white color. During storage, a layer of clear liquid may be released on the surface. With vigorous shaking of the contents of the vial, the homogeneity of the suspension is restored. Suspension of 170 ml in bottles of polyethylene terephthalate. One bottle in a carton box with a 5 ml measuring spoon and a leaflet. Pharmacological action Almagel is a drug that reduces the increased acidity of gastric juice. It is a balanced combination of aluminum and magnesium hydroxides, which are insoluble and hardly enter the body. Almagel has a local effect on the gastric mucosa, protects it from the irritating effect of acids and other harmful substances and food, and reduces the activity of pepsin. The drug reduces the acidity in the esophagus. It has an anti-inflammatory and astringent effect on the mucous membrane of the esophagus, stomach and duodenum. The auxiliary substance sorbitol has a weak carminative and moderate choleretic effect, as well as a moderate laxative effect. Indications for use Symptomatic treatment of diseases of the digestive tract accompanied by increased acidity of the gastric juice: esophagitis, hiatal hernia, gastroesophageal reflux disease (GERD), acute and chronic gastritis, gastroluodenitis, peptic ulcer of the stomach and duodenum, post-resection gastritis and gastroanastomositis in the presence of gastroesophageal reflux (heartburn). Prophylactically to reduce the irritating and ulcerogenic effect of certain drugs on the mucous membrane of the esophagus, stomach and duodenum (for example, corticosteroids, non-steroidal anti-inflammatory drugs). Use during pregnancy and lactation Before taking any medicines, consult your doctor or pharmacist. There are no clinical data on the use of Almagel by pregnant women. The drug is not recommended during pregnancy, but if the drug is necessary, then the duration of treatment should not exceed 5-6 days, and the drug should be taken under medical supervision. It is not recommended to prescribe for toxicosis of pregnant women. There is no data on the intake of the active substances of the drug in difficult milk. Almagel can be used during breastfeeding only after a thorough assessment of the ratio of benefits to the mother and the potential risk to the newborn. During lactation, it is recommended to use no more than 5-6 days under medical supervision. Influence on the ability to drive vehicles and work with machinery Almagel does not affect the ability to drive a car AND work with machinery. The ethanol included in the preparation is contained in quantities that are not able to affect the ability to drive a car and use machinery when taking the recommended daily doses. Interactions with other drugs Please tell your doctor or pharmacist if you are taking or have recently taken other medicines, even if they have not been prescribed for you. With simultaneous treatment, other drugs should be taken 1-2 hours before or after taking Almagel. Almagel reduces the acidity of gastric juice, and this can affect the action of a large number of drugs while taking. Almagel reduces the absorption of digoxin‚ indomethacin, salicylates, chlorpromazine, phenytoin, reserpine, H2-blockers (cimetidine, ranitidine, famotidine), lansoprazole, ? ciprofloxacin, norfloxacin, ofloxacin, enoxacin, grepafloxacin), azithromycin, cefpodoxime, pivampicillin, rifampicin, indirect anticoagulants, barbiturates, fexofenadine, sodium fluoride, dipyridamole, zalcitabine, bile acids (chenodeoxycholic acid and ursodeoxycholic acid), penicillamine glycosides, lankyprolamine, iron, lithium preparations, quinidine, mexiletine, phenothiazine preparations, tetracycline antibiotics, lincosamides, phosphorus preparations, anti-tuberculosis preparations (ethambutol, isoniazid (for oral use), chloroquine, gshococorticoid preparations (known to interact with prednisolone and dexamethasone), kayexelate and ketok onazol. With the simultaneous administration of enteric drugs, the increased alkalinity of gastric juice can lead to accelerated destruction of their membrane and cause irritation of the stomach and duodenum. Almagel can affect the results of some laboratory and functional studies and tests: it reduces the level of gastric secretion and, thus, changes the results of a functional study of its acidity; alters technetium (Tc99) test results, such as bone scans and some esophageal tests, increases serum phosphorus, serum and urine pH values. Contraindications The use of Almagel is not recommended in case of hypersensitivity to the components of the drug, habitual constipation, Alzheimer’s disease, severe abdominal pain of unspecified origin, suspected acute appendicitis, ulcerative colitis, colostomy or ileostomy, chronic diarrhea, hemorrhoids, severe renal failure , hypophosphatemia, during lactation, children under 10 years of age. Ingredients: 5 ml (1 scoop) suspension contains aluminum hydroxide gel, corresponding to 218 mg of aluminum oxide, magnesium hydroxide paste 350 mg, corresponding to 75 mg of magnesium oxide. 10 ml (1 package) suspension contains: aluminum hydroxide gel, corresponding to 436 mg of aluminum oxide, magnesium hydroxide paste 700 mg, corresponding to 150 mg of magnesium oxide. Excipients: hydrogen peroxide solution (30%), sorbitol, hydroxyethyl cellulose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, sodium saccharin, propylene glycol, macrogol 4000, lemon oil, ethyl alcohol 96%, purified water. Dosage and Administration Always take Almagel exactly as directed in this leaflet. If you are not sure about something, ask your doctor or pharmacist. Symptomatic antacid treatment Adults and children over 14 years of age 5-10 ml (1-2 measuring spoons or 1 packet) 3-4 times a day. If necessary, a single dose can be increased to 15 ml (3 measuring spoons). After achieving a therapeutic effect, the daily dose is reduced to 5 ml (1 measuring spoon) 3-4 times a day or 1-2 packets per day for 2-3 months. Patients with renal insufficiency During the treatment of patients with impaired renal function, it is necessary to reduce the daily dose or increase the interval between doses, depending on the severity of renal insufficiency. Children from 10 to 14 years Use at a dose equal to half the adult dose – 1 scoop 2-4 times a day or 2 scoops 1-2 times a day or 1 packet 1-2 times a day. For prophylaxis 5-15 ml (1-3 scoops or 1 packet) 15 minutes before taking irritating drugs. The recommended duration of treatment is 12 days. Before each dose, the suspension must be thoroughly homogenized by shaking the package! The drug is taken 45-60 minutes after a meal and in the evening before bedtime. It is not recommended to take liquids within 15 minutes after taking it. If you have the impression that Almagel is too weak or too strong, consult your doctor or pharmacist. If you missed the next dose of Almagel, take it when the next regular dose comes, thus not increasing the dose. If you have any further questions on the use of this medicine, please ask your doctor or pharmacist. Overdose If you have taken a higher dose than you have been prescribed, seek medical attention immediately! With a single overdose, no other signs of an overdose are observed, except for constipation, flatulence, and a sensation of a metallic taste. With prolonged use of high doses, the formation of kidney stones, the appearance of severe constipation, slight drowsiness, hypermagnesemia are possible. There may also be signs of metabolic alkalosis: changes in mood or mental activity, numbness or muscle pain, nervousness and fatigue, slow breathing, unpleasant taste sensations. In these cases, it is necessary to immediately take measures to quickly remove the drug from the body – gastric lavage, stimulation of vomiting, activated charcoal. If symptoms of an overdose appear, consult a doctor immediately! Side effects Like any medicine, Almagel can cause side effects, although not everybody gets them. From the gastrointestinal tract: constipation may occur, which disappear with a decrease in dose, diarrhea, discoloration of feces; nausea, vomiting, stomach cramps. Laboratory indicators: most often in patients with renal insufficiency and in the case of long-term use or high doses of the drug due to hypermagnesemia, hyperaluminemia, aluminum and magnesium intoxication develops; hypophosphatemia (manifestations of which may be loss of appetite, muscle weakness, weight loss); possible hypocalcemia, hypercalciuria. From the side of the kidneys and urinary tract: nephrocalcinosis, impaired renal function; From the immune system: allergic reactions of local and general type, including itching, urticaria, angioedema and anaphylactic reactions, bronchospasm. From the side of the central nervous system: with prolonged use of the drug in patients with renal insufficiency and patients on dialysis, manifestations of encephalopathy, neurotoxicity (changes in mood and mental activity), dementia, disturbances in Alzheimer’s disease are possible; From the musculoskeletal system: osteoporosis with prolonged use of high doses of the drug with a deficiency of phosphorus in food, osteomalacia may occur; Other: change in taste sensations. With prolonged use of the drug in patients with renal insufficiency and patients on dialysis, manifestations of thirst, lowering blood pressure, hyporeflexia, and the development of microcytic anemia are possible. If any side reaction becomes serious, or if you experience any side effects not described in this leaflet, please contact your doctor or pharmacist. Storage conditions In a place protected from light at a temperature not exceeding 25 ° C. Do not freeze! Keep out of the reach of children! Buy Almagel suspension for oral administration in a bottle of 170 ml No. 1