Furazolidone tablets 50mg №10×2

Name Furazolidone tabl. The main active ingredient furazolidone Release form tablets Dosage 50 mg Pharmacological properties Pharmacodynamics The drug belongs to antimicrobial and antiprotozoal agents. It has a bacteriostatic effect against microbes. The mechanism of action is to disrupt the activity of certain enzyme systems of bacteria. Spectrum of action: gram-positive cocci (Streptococcus, Staphylococcus), gram-negative rods (Escherichia, Salmonella, Shigella, Proteus, Klebsiella, Enterobacter), protozoa (Lamblia). Of the causative agents of intestinal infections, the causative agents of dysentery, typhoid fever and paratyphoid are the most sensitive. Resilience develops slowly. Pharmacokinetics When taken orally, it is rapidly absorbed from the gastrointestinal tract and distributed to tissues, including the central nervous system. Therapeutic concentration in the blood is maintained for 4-6 hours. It does not create high concentrations in the blood and tissues (including the kidneys), since it is largely rapidly metabolized in the liver. The main route of elimination is renal excretion (65%). Partially excreted in the bile, reaching high concentrations in the intestinal lumen, which allows it to be used for intestinal infections. In renal insufficiency, the drug accumulates in the blood due to a slowdown in excretion. Indications for use Assign for the treatment of dysentery, paratyphoid, food poisoning, giardiasis and other diseases caused by susceptible microorganisms. Dosing and Administration The drug is taken orally after a meal, drinking plenty of liquid (100-200 ml). For dysentery, paratyphoid fever, food poisoning, adults are prescribed 2-3 tablets (100-150 mg) 4 times a day (but not more than 800 mg) for 5-10 days. Children over 8 years of age are prescribed the drug at the rate of 6-7 mg / kg of body weight per day; The daily dose is divided into 4 doses. The duration of the course depends on the severity of the disease and the effectiveness and sensitivity to therapy. With giardiasis, adults are prescribed 2 tablets (100 mg) 4 times a day; children over 8 years of age are prescribed the drug at the rate of 6 mg / kg of body weight per day in 3-4 doses. The course of treatment is 5-10 days. The therapeutic effect in the treatment of diarrhea with furazolidone develops within 2-5 days of therapy. Sometimes patients may require a longer duration of treatment. If a satisfactory clinical response is not obtained within 7 days, this means that the pathogen is refractory to the action of furazolidone and the drug should be discontinued. It is possible to prescribe additional therapy with other antibacterial agents or bismuth salts. Higher doses for adults: single – 200 mg, daily – 800 mg. It is not recommended to take Furazolidone for more than 10 days. Use during pregnancy and lactation. The use of the drug during pregnancy is contraindicated. During the period of treatment with the drug, breastfeeding should be stopped. Precautions Use with caution in violations of the functions of the liver, kidneys and in the elderly. The risk of peripheral polyneuropathies increases with anemia, diabetes mellitus, electrolyte imbalance, hypovitaminosis B. For the prevention of neuritis with prolonged use, Furazolidone should be combined with B vitamins. Furazolidone is a monoamine oxidase inhibitor (MAO) and when using it, the same precautions must be observed and when using other MAO inhibitors. Due to the risk of high blood pressure and mental disorders, it is recommended to exclude foods rich in tyramine (cheese, chocolate, smoked meats, etc.) from the diet. It should not be taken simultaneously with Furazolidone drugs for the treatment of coughs and colds. It has the ability to sensitize the body to the effects of alcohol. Due to the risk of disulfiram-like reactions, alcohol should not be taken during Furazolidone therapy and for 4 days after its termination. The drug is not recommended for patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. Children Furazolidone in this dosage form is not used in children under the age of 8 years. Interaction with other drugs With the simultaneous use of Furazolidone with monoamine oxidase inhibitors, sympathomimetics, tricyclic antidepressants and foods containing tyramine, there is a risk of developing a hypertensive crisis. When combined with chloramphenicol and ristomycin, the risk of hematopoiesis suppression increases. Aminoglycosides and tetracycline enhance the antimicrobial effect. Urine alkalizing agents (sodium bicarbonate, sodium bicarbonate, acetazolamide, etc.) reduce the effect of Furazolidone, increasing its excretion in the urine; drugs that acidify urine increase the effect of the drug. Furazolidone increases the inhibition of hematopoiesis against the background of chloramphenicol and ristomycin. Contraindications End-stage chronic renal failure, liver dysfunction, deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation, children under 8 years of age, increased individual sensitivity to the components of the drug and nitrofurans. Do not use for urinary tract infections. Composition One tablet contains the active substance: furazolidone – 50 mg; excipients: lactose monohydrate, anhydrous colloidal silicon dioxide, calcium stearate, potato starch. Overdose Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis). Treatment: drug withdrawal, large fluid intake, symptomatic therapy, antihistamines, B vitamins. Side effects Gastrointestinal disorders: abdominal pain, nausea, vomiting, diarrhea, anorexia, cholestasis. From the side of the central nervous system: headache, dizziness, peripheral neuropathy. On the part of the blood system: rarely – leukopenia, agranulocytosis, hemolysis in persons with a deficiency of glucose-6-phosphate dehydrogenase. Allergic reactions: pruritus, urticaria, rash, including maculopapular. Others: hypoglycemia, orthostatic hypotension, dark yellow urine, fever, weakness. Storage conditions In a place protected from light and moisture, at a temperature not exceeding 25 ° C. Keep out of the reach of children. Buy Furazolidone tablets 50mg No. 10×2 Price for Furazolidone tablets 50mg No. 10×2