Drotaverine hydrochloride tablets 40mg №10×2

Name:
Drotaverine hydrochloride, tablets, 40 mg in container cells, 20 pcs.
Description:
Transparent yellow with a greenish tint solution. The main active ingredient is Drotaverine. Release form Solution. Dosage 40mg. Pharmacological action Drotaverine is an isoquinoline derivative that exhibits an antispasmodic effect on smooth muscles by inhibiting the enzyme phosphodiesterase IV (PDE IV). Inhibition of the PDE IV enzyme leads to an increased concentration of cAMP, which inactivates the myosin kinase light chain and leads to smooth muscle relaxation. Drotaverine inhibits PDE IV in vitro without inhibiting the isoenzymes PDE III and PDE V. To reduce the contractility of smooth muscles, PDE IV is functionally very important, and its selective PDE IV inhibitors can be useful in the treatment of hyperkinetic diseases and various symptoms caused by spastic conditions of the gastrointestinal tract. tract. Drotaverine does not have a side effect on the cardiovascular system, because the smooth muscle cells of the myocardium and blood vessels mainly contain the PDE III isoenzyme. The enzyme hydrolyzing cAMP in myocardial and vascular smooth muscle cells is mainly PDE III isoenzyme, which explains why drotaverine is an effective antispasmodic agent without serious cardiovascular side effects and strong cardiovascular therapeutic activity. The drug is effective in spasms of smooth muscles of both nervous and muscular etiology. Regardless of the type of autonomic innervation, drotaverine acts on smooth muscles located in the gastrointestinal, biliary, urogenital and vascular systems. Due to its vasodilating effect, it enhances tissue circulation. Its action is stronger than that of papaverine, and absorption is faster and more complete, it binds less to plasma proteins. The advantage of drotaverine is that it does not have a stimulating effect on the respiratory system), which was observed after parenteral administration of papaverine. Indications for use: spasms of smooth muscles associated with diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis; spasms of smooth muscles of the urinary tract: nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus. As an auxiliary treatment (if the patient cannot take pills): with spasms of smooth muscles of gastrointestinal origin: peptic ulcer of the stomach and duodenum, gastritis, spasms of the cardia and pylorus, enteritis; in gynecology: algomenorrhea. Method of application and dose If the doctor does not indicate otherwise, the usual average dose for adults is daily 40-240 mg of drotaverine hydrochloride (divided into 1-3 doses per day) intramuscularly. In acute colic (biliary and urolithiasis) 40-8 () mg intravenously. Use during pregnancy and lactationAs shown by the results of preclinical animal studies and retrospective studies of clinical data, oral administration of drotaverine during pregnancy does not lead to either teratogenic or embryotoxic effects. However, when prescribing the drug during pregnancy, caution is necessary. Drotaverine should not be used during childbirth. Due to the lack of necessary clinical data during breastfeeding, it is not recommended to prescribe. Influence on the ability to drive vehicles and potentially dangerous mechanisms After parenteral, and especially intravenous administration of the drug, patients are advised to refrain from driving and working on machines. Precautions Clinical studies of the use of the drug in children are not presented. With low blood pressure, the use of the drug requires caution. With intravenous administration of drotaverine – due to the danger of loss of consciousness – the patient must lie down! In case of hypersensitivity to sodium metabisulfite, parenteral use of the drug should be avoided. Caution should be exercised when parenteral administration of the drug to pregnant women. Interactions with other drugs When taken together with levodopa, the drug reduces the effect of the latter on the symptoms of Parkinson’s disease, while increasing muscle stiffness and trembling (tremor). Contraindications hypersensitivity to the active substance or to any of the excipients of the drug (especially to sodium metabisulphite); severe liver, kidney or heart failure (low cardiac output syndrome); childhood. Composition of the active substance – drotaverine hydrochloride – 40.0 mg; excipients – sodium metabisulphite, rectified ethyl alcohol from food raw materials 95%, water for injection. Overdose An overdose of drotaverine can cause cardiac arrhythmias and conduction disturbances, including complete blockade of the bundle branches and cardiac arrest, which can be fatal. In case of an overdose, the patient should be monitored and receive symptomatic and supportive treatment. Side effects During clinical trials, the researchers reported the following side effects as associated with drotaverine, and presented the following frequency of manifestations: very common (> 1/10); common (> 1/100, < 1/10); uncommon (> 1/1000, < 1/100); rare (> 1/10000, < 1/1000); very rare (< 1/10000) and classified according to the following organ systems: gastrointestinal disorders: rarely: nausea, constipation; nervous system disorders: rarely: headache, dizziness, insomnia; cardiovascular disorders: rarely: palpitations, hypotension; immune system disorders: rarely: an allergic reaction (angioneurotic edema, urticaria, rash, itching) (see section "Contraindications"); unknown: fatal and non-fatal anaphylactic shock has been reported in patients using the injectable form; general diseases and local reactions: reactions at the injection site. In case of side effects, it is necessary to stop taking the drug. In case of side effects that are not mentioned in the instructions, it is necessary to inform the attending physician about this. Storage conditions In a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Buy Drotaverine hydrochloride tablets 40mg No. 10x2 The price of Drotaverine hydrochloride tablets 40mg No. 10x2