Rennie chewable tablets with menthol flavor 680mg/80mg №12×1

DescriptionWhite or yellowish white square tablets with concave surfaces, engraved “RENNIE” on both sides, with a menthol smell. The main active ingredient Calcium carbonate + magnesium carbonate Release form Chewable tablets Pharmacological properties Pharmacodynamics The drug contains antacid substances: calcium carbonate and magnesium carbonate. The principle of action is local, does not depend on the entry of active substances into the systemic circulation. Calcium carbonate has a neutralizing effect. This effect is enhanced by the addition of magnesium carbonate, which also has a neutralizing effect. PharmacokineticsAs a result of the interaction of Rennie with gastric juice, soluble calcium and magnesium salts are formed in the stomach. The level of absorption of calcium and magnesium from these compounds depends on the dose of the drug and individual characteristics. The maximum absorption level is 10% calcium and 15-20% magnesium. In healthy individuals, small amounts of absorbed calcium and magnesium are excreted via the kidneys. In case of impaired renal function, the level of calcium and magnesium concentration in plasma may increase. In the intestine, soluble salts form insoluble compounds that are excreted in the feces. Indications for use Used for heartburn and acid reflux. Method of administration and doses Adults and children over 12 years old: a single dose of 1-2 tablets, for pain – from 4 to 8 tablets per day. The tablet can be chewed or kept in the mouth until completely resorbed. For severe pain, the dose may be increased for a short time up to 12 tablets per day. The duration of taking the drug should not exceed 10 days. Use during pregnancy and lactation There are no reliable data on teratogenesis in animals. When prescribing in high doses and prolonged administration of calcium carbonate, the development of anomalies in the form of ossifications was revealed. When administered at recommended doses to humans, no data on the occurrence of malformations or embryotoxic effects were found. However, data on cases of drug use by pregnant women are insufficient to rule out a possible risk. Therefore, the appointment of the drug to women during pregnancy should be considered only if absolutely necessary. When prescribing a drug to a pregnant woman, it should be borne in mind that magnesium salts can cause the development of diarrhea, when taking calcium salts in a high dose for a long time, there is a risk of hypercalcemia with calcification of internal organs, including kidneys. During the period of breastfeeding, the appointment of Rennie is possible, subject to the recommendations for use. At reception it is necessary to be careful. Precautions Patients are advised to seek medical attention if one or more of the following symptoms are present: weight loss; difficulty swallowing or constant discomfort in the stomach area; digestive disorders that appeared for the first time or have changed; the presence of kidney disease (this information is necessary for monitoring serum calcium levels). Due to the presence of sucrose, the drug is contraindicated in patients with fructose intolerance, malabsorption of glucose and galactose, sucrase-isomaltase deficiency. If the symptoms persist while taking the drug, or the condition worsens, then it is necessary to consult a doctor for examination and treatment. Side effects were observed more often when taken in combination with thiazide diuretics or in patients taking large amounts of milk or dairy products, especially with prolonged use. In the case of taking 4 to 8 tablets per day, it is necessary to limit the duration of treatment as much as possible, after the disappearance of symptoms, the drug should be discontinued. Indication for patients with diabetes mellitus: 1 tablet contains 475 mg of sucrose. Interaction with other drugs Antacids may interact with other drugs. With simultaneous admission, the absorption in the gastrointestinal tract of other drugs taken orally is reduced. As a precautionary measure, it is advisable to take antacids separately from other medicines. It is recommended to take Rennie 2 hours before or after taking other medicines: antihistamine H2; atenolol, metoprolol, propranolol; chloroquine; cyclins; diflunisal; digoxin; diphosphonates; fexofenadine; iron (salts); fluoroquinolones; sodium fluoride; glucocorticoids (described for prednisolone and dexamethasone); indomethacin; kyexalate; ketoconazole; neuroleptics of the phenothiazine series; penicillamine; phosphates; thyroxine. Exercise caution when taking with thiazide diuretics. Increased renal excretion of salicylates due to alkalinization of urine. If you are taking other medicines at the same time, you should consult your doctor. Contraindications Nephrocalcinosis, severe renal failure, hypercalcemia, hypercalciuria, hypophosphatemia; hereditary diseases associated with fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency; hypersensitivity to the ingredients of the drug, myasthenia gravis, intestinal obstruction. Ingredients: calcium carbonate 680 mg; magnesium carbonate basic, heavy 80 mg. Excipients: sucrose, pregelatinized corn starch, potato starch, talc (E553b), magnesium stearate (E572), light liquid paraffin, menthol flavor, lemon flavor. Overdose Predominantly in patients with impaired renal function, prolonged use of large doses of the drug can lead to renal failure, hypermagnesemia, hypercalcemia and alkalosis. In this case, you should stop taking the drug and take a sufficient amount of liquid. In severe cases of overdose (for example, milk-alkali syndrome), a doctor should be consulted, as additional measures to restore water balance may be required. Treatment is symptomatic. Side effect From the side of the immune system: very rarely allergic reactions – rashes, urticaria, Quincke’s edema and anaphylaxis. From the gastrointestinal tract: nausea, vomiting, indigestion and diarrhea. From the side of metabolism and nutrition: in patients with impaired renal function, long-term use of large doses of the drug can lead to the manifestation of reactions associated with overdose – hypermagnesemia, hypercalcemia and alkalosis, which can provoke symptoms from the gastrointestinal tract (nausea, vomiting, constipation) and muscle weakness. From the musculoskeletal system and connective tissue: muscle weakness. From the nervous system: loss of taste, headache. From the side of the kidneys and urinary tract: azotemia. Adverse reactions associated with milk-alkaline syndrome: asthenia and calcification. In the event of adverse reactions, including those not listed in this leaflet, you must stop taking the drug and consult a doctor. Storage conditions At a temperature not exceeding 25 ° C, out of the reach of children. Buy Rennie chewable tablets with menthol flavor 680mg/80mg No. 12×1 Price for Rennie chewable tablets with menthol flavor 680mg/80mg No. 12×1