Piracesin capsules 400mg/25mg №10×6

Name:
Pyracesin
Description:
Hard gelatin capsules of a cylindrical form with the hemispherical ends of white color. The main active ingredient Piracetam + cinnarizine Release form Hard gelatin capsules, 10 capsules in a blister pack, 1 or 6 blister packs in a pack. Dosage 400 mg + 25 mg Special instructions Since Piracezin® contains cinnarizine, the drug may cause a positive reaction in athletes during a doping test. Piracesin® is the drug of choice in cases where piracetam monotherapy causes tension and insomnia in the patient. In the treatment of patients with cortical myoclonus, abrupt discontinuation of treatment (risk of recurrence of seizures) should be avoided. It should be borne in mind that the development of side effects is most typical for patients with mental disorders. Exacerbation of coronary insufficiency often occurs in severe patients; in these cases, reduce the dose or discontinue therapy. Due to the antihistamine activity of cinnarizine, the drug may affect the results of skin allergy tests carried out within 4 days after taking Piracesin®. Due to the effect of piracetam on platelet aggregation, caution should be exercised when prescribing the drug to patients with hemostasis disorders, bleeding symptoms, before an upcoming surgical intervention, previous surgery (including dental), risk factors for bleeding (for example, gastric ulcer and duodenal ulcer bowel), previous intracerebral hemorrhage, taking anticoagulants or antiplatelet agents, including low doses of aspirin. In patients with Parkinson’s disease, the appointment of cinnarizine is possible only if the therapeutic benefits outweigh the possible risk of exacerbation of this disease. As with other antihistamines, cinnarizine may cause epigastric irritation, and taking the drug after meals may reduce gastric irritation. Cinnarizine may cause drowsiness, especially at the very beginning of treatment. Therefore, you should refrain from the simultaneous use of alcohol or CNS depressants. Cinnarizine should be avoided in porphyria. Indications for use Indications for the use of the drug are: symptomatic treatment of memory disorders, intellectual disorders in the absence of a diagnosis of dementia (symptomatic treatment of chronic psychoorganic syndrome); symptomatic treatment of labyrinth and vestibular disorders of vascular origin, Meniere’s syndrome. Dosage and administration For adults, the drug is prescribed 1-2 capsules 3 times a day for 1-3 months, depending on the severity of the disease. The duration of the course of treatment is determined by the doctor, taking into account the characteristics of the disease, the effect achieved and the tolerability of the drug. Since piracetam is excreted from the body by the kidneys, when prescribing the drug to patients with renal insufficiency and elderly patients, the dose should be adjusted depending on the value of creatinine clearance (CC). Patients with renal insufficiency require a dose adjustment of the drug in accordance with the following scheme: Degree of renal insufficiency CC (ml / min) Dose Normal > 80 Usual dose Mild 50-79 2/3 of the usual dose in 2-3 doses Average 30-49 1 / 3 usual doses in 2 doses Severe < 30 1/6 usual dose, single dose End stage - contraindicated In elderly patients, the dose is adjusted in the presence of renal insufficiency; with prolonged therapy, it is necessary to monitor the functional state of the kidneys. Use with caution in patients with impaired liver function. For patients with impaired renal and hepatic function, the drug is prescribed in the same way as for patients with impaired renal function. Use during pregnancy and lactation The drug is contraindicated for the appointment of pregnant women and women who are breastfeeding. Precautions Use in children The use of the drug in children under 18 years of age is not recommended due to the lack of adequate data. Influence on the ability to drive a car, work with machinery While taking the drug, it is recommended to refrain from driving a vehicle and working with potentially dangerous mechanisms. Interaction with other drugs The possibility of changing the pharmacokinetics of piracetam under the influence of other drugs is low, since 90% of piracetam is excreted unchanged in the urine. With simultaneous use with thyroid hormones, there have been reports of confusion, irritability and sleep disturbance. According to a study of patients with recurrent venous thrombosis, piracetam at a dose of 9.6 g / day increases the effectiveness of indirect anticoagulants (there was a more pronounced decrease in platelet aggregation, fibrinogen concentration, von Willebrand factors, blood and plasma viscosity compared with the use of acenocoumarol alone). At concentrations of 142, 426 and 1422 µg/ml, piracetam does not inhibit cytochrome P450 isoenzymes. For a concentration of 1422 µg/ml, minimal inhibition of CYP 2A6 (21%) and 3A4/5 (11%) was observed. However, normal inhibition constants can probably be achieved at higher concentrations. Thus, the metabolic interaction of piracetam with other drugs is unlikely. Taking piracetam at a dose of 20 g / day for 4 weeks did not change the maximum serum concentration and the area under the concentration-time curve of antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, valproate) in patients with epilepsy who received piracetam at a stable dose. The simultaneous use of alcohol, CNS depressants, tricyclic antidepressants may increase the sedative effects of these drugs or cinnarizine. Due to its antihistamine effect, cinnarizine may mask a positive skin test reaction and should therefore be discontinued 4 days before the test. Contraindications Individual intolerance to piracetam or pyrrolidone derivatives, as well as other components of the drug; psychomotor agitation at the time of drug administration; chorea of Huntington; acute violation of cerebral circulation (hemorrhagic stroke); parkinsonism; terminal stage of chronic renal failure (with creatinine clearance less than 20 ml / min); pregnancy, lactation period. Composition One capsule contains: piracetam - 400 mg, cinnarizine - 25 mg. Excipients: calcium stearate, magnesium carbonate basic. The composition of the capsule shell: gelatin, glycerin, purified water, titanium dioxide, sodium lauryl sulfate. Overdose Symptoms: change in consciousness from drowsiness to stupor and coma, vomiting, extrapyramidal symptoms, arterial hypotension, convulsions, dyspeptic symptoms in the form of diarrhea with blood and pain in the abdomen. Treatment: There is no specific antidote. During the first hour after ingestion, it is necessary to wash the stomach. If warranted, activated charcoal may be prescribed. Treatment is symptomatic. Side effects On the part of the blood and lymphatic system: blood clotting disorders On the part of the immune system: anaphylaxis, hypersensitivity reactions Mental disorders: anxiety, depression, agitation, anxiety, confusion, hallucinations On the part of the nervous system: hyperactivity, drowsiness, ataxia, balance disorders, convulsions, exacerbation of epilepsy, headaches, insomnia, tremor, dyskinesia, extrapyramidal disorders, parkinsonism On the part of the organ of hearing and balance: dizziness Gastrointestinal disorders: sensation of dry mouth, abdominal pain, pain in the upper abdomen, diarrhea, nausea , vomiting, cholestatic jaundice. Diseases of the skin and subcutaneous tissue: Quincke's edema, dermatitis, itching, urticaria, hyperhidrosis, lichenoid keratosis, lichen planus, lupus-like reaction Disorders of the reproductive system and mammary glands: increased libido General disorders: weight gain, asthenia, muscle rigidity. In the event of adverse reactions, including those not listed in this leaflet, stop taking the medicine and consult a doctor. Storage conditions Store in a place protected from moisture and light at a temperature of 15 to 25 ° C. Store in a place inaccessible to children. Shelf life 2 years. Do not use after the expiry date stated on the packaging. Buy Piracesin capsules 400mg/25mg №10x6