Bilobil capsules 40mg №10×2

Name:
Bilobil caps 40 mg in a blister. in pack. No. 10×2
Description:
Hard gelatin capsules No. 4, purple-brown body and cap. The contents of the capsules are light brown to dark brown powder with darker particles. Small lumps are allowed. The main active ingredient of ginkgo biloba leaf extract Release formCapsules, 40 mg. 10 capsules in a blister of combined PVC/PVDC material and aluminum foil. 2 or 6 blisters, together with instructions for use, are placed in a cardboard pack. Dosage 40 mg Special instructions Do not exceed the recommended doses of Bilobil®. With the development of a hypersensitivity reaction, the use of the drug must be discontinued. Before surgery, you must inform the doctor about the use of the drug Bilobil®. If you often experience dizziness and tinnitus, you should consult a doctor. In case of sudden deterioration or loss of hearing, you should immediately consult a doctor. Patients with bleeding (hemorrhagic diathesis) and patients receiving anticoagulant therapy should consult a doctor before starting therapy with Bilobil®. It is not recommended to use the drug Bilobil® together with ethanol. Against the background of the use of preparations of Ginkgo biloba in patients suffering from epilepsy, epileptic seizures may occur. Special information on excipients 1 capsule of Bilobil® contains 98 mg of digestible carbohydrates (glucose, lactose, starch), which corresponds to 0.0082 bread units (XE), the maximum daily dose (6 capsules) corresponds to 0.049 XE. Bilobil® contains the dye azorubine (E122), which can cause allergic reactions. Pharmacodynamics Bilobil® of plant origin. Increases the body’s resistance to hypoxia, especially brain tissue. It inhibits the development of traumatic or toxic cerebral edema, improves cerebral and peripheral circulation, improves the rheological properties of blood. It has a dose-dependent regulatory effect on the vascular wall, dilates small arteries, and increases the tone of the veins. Prevents the formation of free radicals and lipid peroxidation of cell membranes. Normalizes the release, re-absorption and catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to connect to receptors. It improves metabolism in organs and tissues, promotes the accumulation of macroergs in cells, increases the utilization of oxygen and glucose, and normalizes mediator processes in the central nervous system. Pharmacokinetics Absorption After oral administration, the bioavailability of terpene lactones (ginkgolide A, ginkgolide B and bilobalide) is 80% for ginkgolide A, 88% for ginkgolide B and 79% for bilobalide. Distribution When administered, peak plasma concentrations were 16-22 ng/mL for ginkgolide A, 8-10 ng/mL for ginkgolide B, and 27-54 ng/mL for bilobalide. Plasma protein binding is 43% for ginkgolide A, 47% for ginkgolide B, and 67% for bilobalide. Elimination The elimination half-life is 3.9 hours for Ginkgolide A, 4-6 hours for Ginkgolide B and 2-3 hours for Bilobalide. Indications for use Symptomatic treatment of cognitive impairment in adults. As part of the complex therapy of dizziness of vestibular origin as an adjunct treatment in addition to vestibular rehabilitation. Symptomatic treatment of tinnitus (ringing or tinnitus). Dosage and administration Inside. Capsules should be swallowed whole with a small amount of water, regardless of the meal time. For symptomatic treatment of cognitive impairment in adults: 1-2 capsules 3 times a day. For dizziness of vestibular origin and symptomatic treatment of tinnitus: 3 capsules per day, distributed throughout the day. The first signs of improvement usually appear after 1 month. The course of treatment is at least 3 months (especially for elderly patients). Conducting a second course is possible after consultation with a doctor. If a dose of the drug was missed or an insufficient amount was taken, its subsequent intake should be carried out as indicated in this instruction, without any changes. Use during pregnancy and lactation The use of the drug Bilobil® is contraindicated during pregnancy and during breastfeeding, due to the lack of sufficient clinical data. Interaction with other drugs It is not recommended to use the drug Bilobil® in patients who are constantly taking acetylsalicylic acid, anticoagulants (direct and indirect action), as well as thiazide diuretics, tricyclic antidepressants, anticonvulsants, gentamicin. There may be isolated cases of bleeding in patients simultaneously taking drugs that reduce blood clotting, a causal relationship of these bleedings with taking Ginkgo biloba preparations has not been confirmed. When used with antihypertensive drugs, it is possible to potentiate the antihypertensive effect. Simultaneous use with efavirenz is not recommended, since its concentration in blood plasma may decrease due to the induction of the CYP3A4 isoenzyme under the influence of Ginkgo biloba extract. An interaction study with talinolol indicates that Ginkgo biloba extract can inhibit intestinal P-glycoproteins. This may increase the exposure of P-glycoprotein-sensitive drugs in the intestine, such as dabigatran, and therefore, caution should be exercised when they are used simultaneously. Contraindications Hypersensitivity to the components of the drug, reduced blood clotting, erosive gastritis in the acute stage, peptic ulcer of the stomach and duodenum in the acute stage, acute cerebrovascular accident, acute myocardial infarction, pregnancy, breastfeeding, children under 18 years of age (efficacy and safety not studied), lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (Bilobil® contains lactose). Composition 1 capsule contains: Active ingredient: Ginkgo biloba leaf extract (Ginkgo biloba leaf extract dry*) 40.00 mg hard gelatin capsule (body and cap): Iron oxide black (E172), iron oxide red (E172), titanium dioxide (E171), indigo carmine (E132), azorubine dye (E122), gelatin * Ginkgo biloba leaf dry extract Ginkgo biloba leaves (Ginkgo biloba L., Ginkgo family (Ginkgoaceae), folium). The ratio of the amount of medicinal plant material to the amount of the original extract: 35-67:1. The extractant is acetone/water. Overdose At present, no cases of overdose of Bilobil® have been reported. In the event of an overdose, treatment is symptomatic. Side effectsClassification of the incidence of side effects according to the recommendations of the World Health Organization (WHO): very often? 1/10 often from ? 1/100 to < 1/10 infrequently from ? 1/1000 to <1/100 rare from ? 1/10000 to < 1/1000 very rare < 1/10000, including isolated reports frequency unknown cannot be estimated from the available data. From the digestive system: very rarely: nausea, vomiting, diarrhea. From the nervous system: very rarely: headache, dizziness, insomnia. Allergic reactions: very rarely: hyperemia, edema, pruritus. On the part of the hemostasis system: very rarely: decreased blood clotting. There are reports of the occurrence of biloba bleeding with long-term use of Ginkgo preparations in patients who simultaneously took drugs that reduce blood clotting. From the senses: the frequency is unknown: hearing loss. In case of any adverse events, the drug should be discontinued and consult your doctor. Storage conditions At a temperature not exceeding 25 ° C, in the original packaging. Keep out of the reach of children. Buy Bilobil capsules 40mg No. 10x2 Price for Bilobil capsules 40mg No. 10x2