Nifuroxazide tablets p/o 100mg №10×3

Name Nifuroxazide tablets 100mg №30 The main active ingredient Nifuroxazide Release form tablets Dosage 100 mg Pharmacological properties Pharmacodynamics Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran, has a local antibacterial effect against gram-positive (Staphylococcus family) and gram-negative (Enterobacteriaceae family: Escherichia spp., Citrobacter spp., Enterobacter spp., Klebsiella spp. ., Salmonella spp.) bacteria. Nifuroxazide does not show antibacterial activity against bacteria of the species Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa. Nifuroxazide does not destroy the saprophytic intestinal flora. Does not cause the emergence of strains resistant to nifuroxazide. The exact mechanism of action is unknown. Nifuroxazide can inhibit the activity of dehydrogenases and disrupt protein synthesis in bacterial cells. Efficacy does not depend on the pH in the intestinal lumen. Pharmacokinetics Absorption of nifuroxazide is extremely low, provided there are no changes in the intestinal mucosa. Excreted by the intestines. Indications for use Treatment of acute diarrhea of bacterial origin in the absence of signs of invasion (for example, deterioration in general condition, fever, signs of toxic infection). Concomitant rehydration therapy is determined by the severity of diarrhea, age, gender, body weight of the patient, and the presence of comorbidities. Dosage and administration The drug is intended for adults and children over 6 years of age. Take the tablets inside, without chewing, with a drink? cups of chilled boiled water. Adults: 800 mg per day (4 tablets 2 times a day; or 2 tablets 4 times a day). Children over 6 years: 600-800 mg per day (2 tablets 3 times a day; or 2 tablets 4 times a day). For children under 6 years of age, another dosage form of nifuroxazide should be used. The duration of taking nifuroxazide is limited to 7 days. Use during pregnancy and lactation It is not recommended to use the drug during pregnancy and lactation. Precautions During treatment, it is necessary to replenish fluid loss orally or parenterally (depending on the patient’s condition). The use of alcoholic beverages during treatment with nifuroxazide may cause a disulfiram-like reaction. Nifuroxazide is not prescribed as monotherapy for the treatment of intestinal infections accompanied by septicemia. In the case of infectious diarrhea with clinical manifestations of generalization of the infection, it is necessary to prescribe antibacterial drugs of systemic action. If during the period of treatment with the drug symptoms of dehydration appear, it is necessary, depending on the clinical condition of the patient, to carry out rehydration therapy (for adults – about 2 liters of fluid per day). In the case of persistent diarrhea after 3 days of treatment, an in-depth diagnosis should be carried out, the purpose of which is to determine the cause of the symptoms, and consideration should be given to starting antibiotic therapy. In case of hypersensitivity reactions, such as shortness of breath, skin rash, itching, the use of the drug should be discontinued. Nifuroxazide should be used in compliance with a strict diet, excluding juices, raw fruits and vegetables, spicy and indigestible foods from the diet. Interaction with other drugs In the treatment with nifuroxazide, simultaneous administration of oral agents should be avoided due to the strong adsorption properties of the drug. Because nifuroxazide is not absorbed from the gastrointestinal tract, the possibility of interaction with other systemic drugs is unlikely. It is not recommended to take the drug with drugs that can cause withdrawal syndrome or antidepressants. Contraindications children’s age up to 6 years; hypersensitivity reactions to 5-nitrofuran derivatives; pregnancy. Composition One tablet contains: active ingredient? nifuroxazide – 100 mg; excipients: anhydrous colloidal silicon dioxide, gelatin, talc, magnesium stearate, potato starch, opadry II (contains: partially hydrolyzed polyvinyl alcohol; macrogol 3350 (polyethylene glycol); talc; titanium dioxide E 171; aluminum varnish based on yellow quinoline E 104 ; iron oxide yellow E 172). Overdose Symptoms of drug overdose are not described. In case of overdose, gastric lavage and symptomatic treatment are recommended. Side effectsUsually nifuroxazide is well tolerated. However, the following side effects may develop. On the part of the hematopoietic and lymphatic systems: one case of granulocytopenia has been described. From the gastrointestinal tract: in cases of individual hypersensitivity to nifuroxazide, abdominal pain, nausea and exacerbation of diarrhea may occur. In the event of the appearance of these symptoms of low intensity, there is no need for special therapy or discontinuation of the drug. With a significant intensity of the above symptoms, you should stop taking the drug. In the future, the patient should not take nitrofuran derivatives. On the part of the skin and subcutaneous tissue: allergic reactions may develop (skin rash, urticaria, Quincke’s edema, anaphylactic reactions). In case of development of hypersensitivity reactions, such as shortness of breath, skin rash, itching, you should stop taking the drug. Storage conditions In a place protected from light and moisture, at a temperature of 15 ° C to 25 ° C. Keep out of the reach of children. Buy Nifuroxazide tablets p/o 100mg №10×3 Price for Nifuroxazide tablets p/o 100mg №10×3