Bisacodyl rectal suppositories 10mg №5×2

Name:
Bisacodyl supp. rect. 10 mg in a cell. pack No. 5×2
Description:
Cylindroconical suppositories of white or white color with a yellowish tint. On the cut, the presence of an air and porous rod, and a funnel-shaped recess is allowed. The main active ingredient is Bsacodyl Release form Suppositories Dosage 10 mg Pharmacodynamics Diphenylmethane derivative. It has a laxative and carminative effect. The action of the drug is due to irritation of the receptors of the nerve endings of the mucous membrane of the colon, which leads to an increase and acceleration of intestinal motility. It inhibits Na + K + ATP-ase of the colon mucosa, disrupting the absorption of water and electrolytes. Stimulates the secretion of prostaglandins E1 and the secretion of mucus in the large intestine. Pharmacokinetics Absorption of bisacodyl from the large intestine is minimal. With rectal administration, a pronounced laxative effect occurs within 15-60 minutes. Indications for use Constipation due to hypotension and sluggish peristalsis of the colon; constipation after surgery, childbirth, diet changes; stool regulation for hemorrhoids, proctitis; preparation of the large intestine for surgical interventions, X-ray and instrumental studies. Method of administration and doses The use of this medicinal product is possible only after consulting a doctor! Do not stop taking Bisacodyl without first consulting with your doctor! If you have any doubts or questions, please contact your doctor. Rectally. Adults and children over 14 years old: 10-20 mg (1-2 suppositories) per day. Children aged 10 to 14 years: 10 mg (1 suppository) 1 time per day. In preparation for surgery or diagnostic studies: in the evening and in the morning, 10 mg (1 suppository). Use during pregnancy and lactation If you are pregnant or breastfeeding, if you suspect that you are pregnant or do not exclude the possibility of pregnancy, inform your doctor. The use of bisacodyl is not recommended during pregnancy due to lack of clinical and preclinical data. Bisacodyl passes into breast milk, so the use of bisacodyl is not recommended during breastfeeding. Precautions The following measures should precede the drug treatment of constipation: adequate physical activity and drinking regimen, the use of a sufficient amount of dietary fiber, The use of laxatives for more than 10 days is not recommended. With prolonged use, the development of dependence is possible (the need to increase the dosage and the development of severe constipation after discontinuation of the drug). Prolonged and excessive use of the drug can cause irritation and melanosis of the colon, disturbance of water and electrolyte balance, in particular hypokalemia. It is recommended not to use this drug for hemorrhoids, anal fissures, ulcerative colitis. With diarrhea or abdominal pain, the use of the drug should be temporarily discontinued. With caution, bisacodyl is prescribed to patients with hepatic and / or renal insufficiency. Use in childhood The drug is contraindicated in children under 10 years of age. Interaction with other drugs If you are currently or have recently taken other drugs, tell your doctor. The simultaneous use of bisacodyl with drugs that can cause the development of polymorphic ventricular tachycardia of the “pirouette” type is not recommended: – antiarrhythmic drugs: amiodarone, bretilium, disopyramide, quinidine, sotalol; – other agents: astemizole, bepridil, intravenous erythromycin, halofantrine, pengamidine, sultopride, terfenadine, vincamine. Risk factors for the development of polymorphic ventricular tachycardia of the “pirouette” type are hypokalemia, bradycardia, and prolongation of the OT interval. Drug combinations that require caution: – cardiac glycosides. Hypokalemia increases the toxic effects of digitalis preparations. It is necessary to monitor the level of potassium in the blood serum and, if necessary, ECG control; – other drugs leading to the excretion of potassium: kaliuretic diuretics (alone or in combination), amphotericin B for internal administration, corticosteroids, tetracosactide. It is necessary to monitor the level of potassium in the blood serum and, if necessary, correct it. Contraindications Absolute contraindications: – hypersensitivity to bisacodyl or to any of the excipients; – severe dehydration with electrolyte disturbances; – inflammatory bowel disease, ulcerative colitis, Crohn’s disease; – Acute abdomen syndrome, severe abdominal pain accompanied by nausea and vomiting; – intestinal obstruction of various origins; – children’s age up to 10 years. Relative contraindications: Taking drugs that can cause the development of polymorphic ventricular tachycardia of the “pirouette” type. Composition 1 suppository contains: Active substance: bisacodyl 10 mg. Excipients: semi-synthetic glycerides up to 1.0 g. Overdose The use of bisacodyl in high doses can lead to diarrhea, abdominal pain and clinically significant loss of potassium and other electrolytes. Chronic overdose can cause diarrhea, abdominal pain, hypokalemia, muscle weakness due to hypokalemia. Treatment: in case of large fluid loss, correction of electrolyte disturbances is necessary. This is especially important in elderly patients and in young people. It may be necessary to prescribe antispasmodics. Side effects If side effects occur, tell your doctor about it. This applies to all possible side effects, including those not described in this package insert. MedDRA convention for frequency Very common (≥1/10); frequent (?1/100, <1/10); infrequent (?1/1000, <1/100); rare (?1/10000, <1/1000); very rare (<1/10000), with an unknown frequency (cannot be estimated from the available data). Immune system disorders: rare - allergic reactions. Gastrointestinal disorders: infrequent - abdominal discomfort, frequent - intestinal colic, diarrhea; with an unknown frequency - dehydration, intestinal atony. Metabolic and nutritional disorders: frequent - disorders of water and electrolyte metabolism (hypokalemia). Musculoskeletal and connective tissue disorders: frequent - muscle weakness, abdominal cramps. Cardiovascular disorders: with an unknown frequency - arterial hypotension. Local reactions: rare - pain and burning in the rectal area, inflammation of the rectal mucosa (proctitis). Storage conditionsKeep in a dry, dark place at a temperature of 15-25o C. Keep out of the reach of children. Buy Bisacodyl rectal suppositories 10mg №5x2 Bisacodyl rectal suppositories 10mg №5x2