Nazol Advance nasal spray 0.5mg/ml 30ml №1

Name:
Nazol advance.
Description:
Transparent colorless liquid with a slight smell of menthol, eucalyptol and camphor. The main active ingredient is oxymetazoline. Release formNasal spray. Pharmacological groupMeans for the treatment of diseases of the nose. Decongestants and other topical agents in rhinology. ATC code: R01AA05 Pharmacological propertiesOxymetazoline hydrochloride is a synthetic adrenomimetic. The vasoconstrictor effect is manifested by a decrease in blood flow, a decrease in swelling of the mucous membranes of the nasal passages, paranasal sinuses and the Eustachian tube. This restores breathing through the nose, disturbed by the flu, colds and allergic diseases. Local vasoconstriction of the mucous membranes of the nose and paranasal sinuses occurs 5-10 minutes after injection of the drug into the nasal cavity. Indications for use Acute, allergic and vasomotor rhinitis; to restore drainage in case of inflammation of the paranasal sinuses of the nasal cavity, eustachitis, otitis media; to eliminate edema before diagnostic manipulations in the nasal passages. Method of application and doses Inject into each nasal passage, while injecting do not tilt your head back. Adults and children over 6 years of age, make 1 injection in each nasal passage. Repeat injections no earlier than 12 hours later. Do not exceed the recommended dosage and do not use the drug for more than 7 days. Use during pregnancy and lactation Pregnancy Limited data on the use of oxymetazoline in the first trimester of pregnancy indicate the absence of adverse effects on pregnancy or the health of the fetus / newborn. Other epidemiological data are not yet available. The use of the spray during pregnancy is recommended only after an assessment of the benefit/risk ratio. Since an overdose can disrupt the blood supply to the unborn child, the recommended dosage should be strictly observed during pregnancy. Breast-feeding The use of the spray during lactation is possible only after assessing the benefit / risk ratio. Since an overdose of oxymetazoline can reduce milk production, the recommended dosage should not be exceeded during breastfeeding, since there is no data on the penetration of oxymetazoline into breast milk. Precautions With prolonged use and overdose of topical decongestants, their effect may weaken. As a consequence of their abuse, there may be: reactive hyperemia of the nasal mucosa (rebound effect), chronic swelling of the nasal mucosa (drug-induced rhinitis), atrophy of the mucous membrane. Caution should be exercised in patients with porphyria. Use only after assessing the benefit / risk ratio. Benzalkonium chloride and propylene glycol, which are part of the excipients, can cause allergic skin reactions (irritation, itching). Benzalkonium chloride with prolonged use can cause swelling of the nasal mucosa. Interaction with other drugs The combined use of oxymetazoline and tricyclic antidepressants, maprotiline, MAO inhibitors, pressor agents can lead to an increase in blood pressure. Therefore, the combined use of these agents should be avoided. ContraindicationsIncreased individual sensitivity to the ingredients of the drug or other adrenergic drugs; atrophic rhinitis; inflammation of the skin and mucous membrane of the vestibule of the nose and the formation of crusts (dry rhinitis); arterial hypertension in severe form; severe atherosclerosis; tachycardia; cardiac asthma; increased intraocular pressure, angle-closure glaucoma; hyperthyroidism; diabetes; pheochromocytoma; severe renal dysfunction; difficulty urinating associated with an enlarged prostate; after transsphenoidal hypophysectomy or after other surgical intervention that affects the dura mater; simultaneous reception of MAO inhibitors or within 2 weeks after their cancellation; children’s age up to 6 years. Active ingredient: oxymetazoline hydrochloride 0.5 mg/ml. Excipients: camphor (racemic camphor), menthol (levomenthol), eucalyptol (cineol), benzalkonium chloride, polysorbate 80, propylene glycol, sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, disodium edetate dihydrate, concentrated hydrochloric acid, purified water. OverdoseSymptoms After excessive administration of the drug into the nose or accidental ingestion of the contents of the vial, symptoms of both stimulation and inhibition of the central nervous system (CNS), cardiovascular and pulmonary systems can be observed. CNS stimulation is manifested by the following symptoms: anxiety, agitation, hallucinations, convulsions. Symptoms of inhibition: decrease in body temperature, lethargy, drowsiness and coma. The following additional symptoms may be noted: miosis, mydriasis, fever, sweating, pallor, cyanosis, palpitations, tachycardia, bradycardia, arrhythmia, cardiac arrest, arterial hypertension, arterial hypotension, pulmonary edema, nausea and vomiting, respiratory depression and apnea, mental disorders. In case of overdose in children, CNS disorders often occur, accompanied by convulsions, bradycardia, arterial hypertension, hypotension up to shock, apnea and coma, hallucinations. Treatment In case of severe overdose, intensive therapy is carried out. Apply activated charcoal (adsorbent), sodium sulfate (laxative) or magnesium, gastric lavage to reduce the absorption of oxymetazoline. Vasopressors are contraindicated. As an antidote, non-selective a-blockers are indicated. If necessary: temperature reduction, anticonvulsant therapy and artificial ventilation of the lungs. Side effects Oxymetazoline is generally well tolerated and side effects, if they occur, are mild and temporary. Often: burning or dryness of the nasal membranes, sneezing. Infrequently: after the effect of the drug has passed, a strong feeling of “congestion” of the nose (reactive hyperemia), epistaxis, allergic reactions (angioedema, urticaria, itching). Rarely: palpitations, tachycardia, arterial hypertension. Very rare: Infantile apnea, insomnia, fatigue (drowsiness, sedation), headache, restlessness, hallucinations (mainly in children), arrhythmia, convulsions (especially in children). Not known: dizziness, lightheadedness, trembling, nervousness, agitation, anxiety, blurred vision, increased nasal discharge, increased nasal congestion, dry mouth, irritation of the nose and throat, nausea, rash, weakness. If the listed side reactions occur, as well as a reaction not listed in the package leaflet of the medicinal product, you should consult a doctor. Storage conditions At a temperature not exceeding 30 ° C, out of the reach of children. 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