Bromhexine Grindeks pills 8mg №10×5

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Bromhexine Grindeks tab.8mg in a blister in pack No. 10×5
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Pills The main active ingredient Bromhexine hydrochloride Release form10 pcs. – cellular contour packings (5) – packs of cardboard. 50 pcs. – plastic bottles (1) – cardboard packs. Dosage 8 mg in a blister in pack No. 10×5 Special instructions In case of gastric ulcer, as well as indications of gastric bleeding in history, Bromhexine should be used under medical supervision. Use with caution in patients suffering from bronchial asthma. Bromhexine is not used simultaneously with drugs containing codeine, because. this makes it difficult to cough up loose sputum. It is used as part of combined preparations of plant origin with essential oils (including eucalyptus oil, anise oil, peppermint oil, menthol). Pharmacological action The drug has a mucolytic (secretolytic) and expectorant effect. The mucolytic effect is associated with the depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect. Pharmacokinetics When taken orally, bromhexine is almost completely (99%) absorbed within 30 minutes. Bioavailability is 80% due to the effect of “first pass” through the liver. In plasma, Bromhexine binds to proteins, crosses the blood-brain and placental barriers. Bromhexine undergoes demethylation and oxidation in the liver. The elimination half-life is 15 hours due to slow reverse diffusion from tissues. Excreted by the kidneys. In chronic renal failure, the release of bromhexine metabolites is impaired. With repeated use, Bromhexine can accumulate. Indications for use Bronchopulmonary diseases accompanied by the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, emphysema, pneumoconiosis), chest injuries, pre- and postoperative period. Dosing and Administration Bromhexine is taken orally, regardless of food intake. Adults appoint 1 – 2 tablets 3 – 4 times a day; children from 3 to 5 years – 2 mg, from 6 to 14 years – 4 mg 3 times a day. The course of treatment is from 4 to 28 days. During treatment, it is recommended to consume a sufficient amount of fluid, which supports the secretolytic effect of bromhexine. Interaction with other drugs Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases. Bromhexine is not prescribed simultaneously with drugs containing codeine, as this makes it difficult to expectorate liquefied sputum. Bromhexine promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue. Bromhexine is not compatible with alkaline solutions. Contraindications Hypersensitivity to the components of the drug; pregnancy (1 trimester); lactation period; children’s age up to 3 years. Composition Active substance: bromhexine hydrochloride – 0.008 g. Excipients: sugar, milk sugar, potato starch, calcium stearate. Side effects Rarely, with prolonged use of the drug, nausea, vomiting, dyspepsia, exacerbation of peptic ulcer, allergic reactions (skin rash, rhinitis, etc.), increased levels of transaminases in the blood serum are possible. In these cases, the drug should be discontinued. Storage conditionsKeep in a dry, dark place. Buy Bromhexine Grindeks pills 8mg No. 10×5 Price for Bromhexine Grindeks pills 8mg No. 10×5