Bromhexine Grindeks tablets for children 4mg №10×5

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Bromhexine Grindeks tab.d/children 4mg in a blister pack No. 10×5
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Round flat-cylindrical white tablets with a bevel. The main active ingredient Bromhexine hydrochloride Release form 10 pcs. – cellular contour packings (5) – packs of cardboard. Dosage 4 mg in a blister in pack No. 10×5 Special instructions In case of gastric ulcer, as well as indications of gastric bleeding in history, Bromhexine should be used under medical supervision. Use with caution in patients suffering from bronchial asthma. Bromhexine is not used simultaneously with drugs containing codeine, because. this makes it difficult to cough up loose sputum. It is used as part of combined preparations of plant origin with essential oils (including eucalyptus oil, anise oil, peppermint oil, menthol). Pharmacological action Mucolytic agent with expectorant action. Reduces the viscosity of bronchial secretions by depolarizing the acidic polysaccharides contained in it and stimulating the secretory cells of the bronchial mucosa, which produce a secret containing neutral polysaccharides. It is believed that bromhexine promotes the formation of surfactant. Pharmacokinetics Bromhexine is rapidly absorbed from the gastrointestinal tract and is extensively metabolized during the “first pass” through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 hour. It is widely distributed in body tissues. About 85-90% is excreted in the urine mainly in the form of metabolites. The metabolite of bromhexine is ambroxol. The binding of bromhexine to plasma proteins is high. T1 / 2 in the terminal phase is about 12 hours. Bromhexine penetrates the BBB. In small quantities it penetrates the placental barrier. Only small amounts are excreted in the urine with a T1 / 2 of 6.5 hours. The clearance of bromhexine or its metabolites may decrease in patients with severely impaired liver and kidney function. Indications for use Respiratory diseases accompanied by the formation of a hard-to-remove viscous secretion: tracheobronchitis, chronic bronchitis with a broncho-obstructive component, bronchial asthma, cystic fibrosis, chronic pneumonia. Dosing and Administration Bromhexine is taken orally, regardless of food intake. In the process of treatment, it is recommended to consume a sufficient amount; fluid, which supports the secretolytic effect of bromhexine. The course of treatment is from 4 to 28 days. Tablets for children. Children from 6 to 14 years old – 4-8 mg 3 times a day. Bromhexine syrup is recommended for children aged 1 to 6 years. PrecautionsRenal and / or liver failure, bronchial diseases, accompanied by excessive accumulation of secretion, history of gastric bleeding, liver disease, brain disease, epilepsy, alcoholism, childhood, a tendency to develop drug dependence. Interaction with other drugs Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases. Bromhexine is not prescribed simultaneously with drugs containing codeine, since the suppression of the cough reflex makes it difficult to expectorate liquefied sputum. Bromhexine promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue. Ethanol (alcohol), which is part of the syrup, may change the effect of other medicines. The combined use of bromhexine with certain non-steroidal anti-inflammatory drugs (for example, salicylates, phenylbutazone or butadiene) can cause irritation of the gastric mucosa. Bromhexine is not compatible with alkaline solutions. Contraindications Hypersensitivity to the components of the drug, including sorbitol (syrup), lactose and sucrose (tablets for children), pregnancy, lactation, gastric ulcer, children under 6 years of age – 60 mg, lactose monohydrate – 30 mg, potato starch – 5 mg, magnesium stearate – 1 mg. OverdoseIntoxication with bromhexine in humans has not yet been established. Acute drug poisoning in experimental animals causes increased salivation, nausea, diarrhea, vomiting, and a decrease in blood pressure. – In case of an overdose of bromhexine administered orally, it is necessary first of all to wash the stomach, monitor blood circulation parameters, and carry out symptomatic therapy. Side effects Rarely, with prolonged use of the drug, dizziness, headache, nausea, vomiting, dyspeptic symptoms, exacerbation of gastric and duodenal ulcers, allergic reactions (skin rash, swelling of the face, rhinitis, etc.), increased levels of transaminases in blood serum are possible. In these cases, the drug should be discontinued. Storage conditions Store in a dry, dark place at a temperature not exceeding 25 °C. Buy Bromhexine Grindeks tablets for children 4mg №10×5 The price of Bromhexine Grindeks tablets for children 4mg №10×5