Milt nasal drops (2.5mg/0.25mg)/1ml 10ml №1

Name Milt drops. Release form Drops. MNN Dimethindene + phenylephrine. FTGAntiallergic agent (h1-histamine receptor blocker + alpha-adrenergic agonist). General characteristics Clear colorless or slightly yellowish liquid with a slight specific odor. Composition Active ingredients: 1 ml of the drug contains phenylephrine 2.5 mg, dimethindene maleate 0.25 mg; excipients: benzalkonium chloride; lavender distillate; sorbitol (E 420); citric acid, monohydrate; disodium phosphate dodecahydrate; water for injections. Classification code Means used in diseases of the nasal cavity. ATC code R01AB01. Pharmacological properties Pharmacodynamics. “Milt nasal drops” is a combined preparation containing phenylephrine and dimethindene. The drug reduces nasal discharge and helps to cleanse the nasal passages without disturbing the physiological functions of the ciliated epithelium and nasal mucosa. Phenylephrine belongs to the sympathomimetic amines. It is used as a nasal decongestant with a moderate vasoconstrictive effect, selectively stimulates α1-adrenergic receptors of the cavernous venous tissue of the nasal mucosa. Thus, it quickly and permanently eliminates swelling of the nasal mucosa and paranasal sinuses. Dimetindene is a histamine H1 receptor antagonist that exhibits an antiallergic effect. Effective at low doses, well tolerated. Pharmacokinetics. “Milt nasal drops” are applied topically, so the activity of the agent does not correlate with the concentration of active substances in the blood plasma. With accidental oral administration, the bioavailability of phenylephrine decreased and amounted to approximately 38%, the elimination half-life was about 2.5 hours. The systemic bioavailability of dimethindene after oral administration in solution is about 70%, the half-life is about 6 hours. Indications for use Symptomatic treatment of colds, nasal congestion, acute and chronic rhinitis, seasonal (hay fever) and non-seasonal allergic rhinitis, acute and chronic sinusitis, vasomotor rhinitis. Auxiliary therapy for acute otitis media. Preparation for surgery in the nasal area and elimination of swelling of the nasal mucosa and paranasal sinuses after surgery. Method of application and dosage Before the introduction of the drug, you should thoroughly clean your nose. Children under 1 year (after consulting a doctor) 1 drop in each nasal passage 3-4 times a day. Children from 1 to 6 years old 1 or 2 drops in each nasal passage 3-4 times a day. Adults and children over 6 years: 3 or 4 drops in each nasal passage 3-4 times a day. The duration of treatment should not exceed 7 days and depends on the course of the disease. Side effectsUsually the drug is well tolerated. In some cases, mild temporary local reactions from the nasal mucosa (burning sensation or dryness) are possible. Very rarely: the development of allergic reactions (in particular, local skin reactions, itching, swelling of the eyelids, face, general weakness). Contraindications Hypersensitivity to any of the components of the drug. Due to the content of phenylephrine, this drug, like other vasoconstrictors, is contraindicated in atrophic rhinitis, as well as in patients taking monoamine oxidase inhibitors (MAOIs) or who have taken them in the previous 14 days. Overdose In case of accidental use of the drug by young children inside, no serious side effects were reported. Most cases were asymptomatic, very rarely reported feeling of fatigue, stomach pain, mild tachycardia, increased blood pressure, excitability, insomnia, pallor of the skin. Treatment: the use of activated charcoal, it is possible to use laxatives for young children (gastric lavage is not required); adults and children are prescribed to drink plenty of fluids. Precautions “Milt nasal drops” should not be used for longer than 1 week. Prolonged or excessive use of the drug can cause tachyphylaxis and the effect of “rebound” (drug rhinitis). As with other vasoconstrictors, the recommended dose should not be exceeded. Excessive use of the drug, especially in children and the elderly, can cause systemic manifestations of the drug. The drug should be used with caution in patients with cardiovascular diseases, arterial hypertension, angle-closure glaucoma, and thyroid diseases. Children. For children under 1 year old, “Milt Nasal Drops” is recommended to be used only after consulting a doctor. Use during pregnancy or lactation The drug is not prescribed during pregnancy. Breastfeeding women are not prescribed the drug. The ability to influence the reaction rate when driving vehicles or working with other mechanisms Does not affect. Interaction with other drugs The drug is contraindicated in patients who are taking monoamine oxidase (MAO) inhibitors or have taken them in the previous 14 days. Vasoconstrictors should be used with caution in patients taking tricyclic antidepressants and antihypertensive drugs such as β-blockers. Storage conditions and shelf life Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Best before date. 2 years. Shelf life after opening the vial is 4 months. Do not use the drug after the expiration date indicated on the package. Holiday conditions Without a prescription. UpakovkaPo 10 ml in a bottle. 1 bottle in a pack. Buy Milt nasal drops (2.5mg/0.25mg)/1ml 10ml №1 Price for Milt nasal drops (2.5mg/0.25mg)/1ml 10ml №1 25mg)/1ml 10ml №1