Nafazolin-RUBICON nasal drops 1mg/ml 15ml №1

Nafazolin-RUBICON Description Clear, colorless or yellowish solution. The main active ingredient is Naphazoline nitrate. Release form Nasal drops. Dosage Naphazoline nitrate-1.00 mg. Pharmacological action Means to eliminate inflammatory edema (decongestants) and other topical agents for rhinology. Sympathomimetics. Indications for use To reduce swelling of the nasal mucosa in acute rhinitis, as an aid in sinusitis, otitis media. Method of administration and doses Adults and adolescents from 12 years old: 2-4 drops in each nasal passage 3 times a day. The drug can be used up to 5 days. If breathing becomes free, the drug can be stopped earlier. Repeated use of the drug is possible only a few days after its withdrawal. If the patient has forgotten to use the drug, then he can use it immediately, and the subsequent dose should be applied at the prescribed interval. Do not use two doses at once. Performing the instillation procedure: before using the drug and 5 minutes after its use, it is necessary to clean the nasal passages. Remove the cap from the vial before use. Tilt your head back in a sitting position or lie down, gently insert the tip of the nozzle of the bottle turned upside down into one of the halves of the nose, drip the drug into each half of the nose, gently tilt your head from side to side several times. After use, clean the tip of the nozzle, close the vial with a cap. The vial should only be used by one person due to the risk of infection transmission. Use during pregnancy and lactation During pregnancy and lactation, it is not recommended to use the drug because of the risk of naphazoline entering the systemic circulation. Precautions The use of the drug in chronic atrophic rhinitis is not recommended. If it is necessary to use a solution of naphazoline for a long time, it is imperative to interrupt treatment for several days every 5 days in order to avoid the development of tolerance. With caution, the drug should be used in patients suffering from pheochromocytoma, porphyria and prostatic hyperplasia, severe diseases of the cardiovascular system (arterial hypertension, coronary heart disease (CHD), metabolic disorders (diabetes mellitus, hyperthyroidism) and with simultaneous treatment with MAO inhibitors and other drugs that increase blood pressure.It is also necessary to be careful during general anesthesia with the use of anesthetics that increase the sensitivity of the myocardium to sympathomimetics (for example, halothane) in patients with bronchial asthma.The drug contains benzalkonium chloride, which can cause irritation or swelling of the nasal mucosa , especially with prolonged use.Continuous use of decongestant drugs can lead to chronic edema and mucosal atrophy.Prolonged use and overdose of the drug should be avoided.Patients who take you Juice doses of the drug should be under medical supervision due to the possible occurrence of cardiovascular and neurological side effects (hypertension, arrhythmia, palpitations, headaches, dizziness, drowsiness or insomnia). Interaction with other drugs Naphazoline may interact with MAO inhibitors due to inhibition of the catabolism of vasopressor amines. Naphazoline may enhance the effect of alpha-adrenergic stimulation in combination with other drugs that contain sympathomimetic amines or beta-blockers (especially non-selective beta-1 blockers). Contraindications-Children’s age up to 12 years. – Hypersensitivity, severe diseases of the cardiovascular system (arterial hypertension, coronary heart disease, severe atherosclerosis), metabolic disorders (diabetes mellitus, increased thyroid function), chronic rhinitis, severe eye diseases, angle-closure glaucoma, tumor of the adrenal glands (pheochromocytoma), bronchial asthma, simultaneous use of monoamine oxidase inhibitors (MAO) and a period of up to 10 days after the end of their use. – Atrophic rhinitis with dryness of the nasal mucosa. -First trimester of pregnancy. – Condition following transsphenoidal hypophysectomy or other surgical procedures that may have resulted in damage to the dura mater. Composition 1 ml of solution contains: Active substance: naphazoline nitrate-1.00 mg; Excipients: boric acid, disodium edetate, sodium chloride, benzalkonium chloride, sodium hydroxide, purified water. OverdoseChildren’s age: Rare cases of intoxication were observed in children after accidental ingestion or use of too high doses. The toxic dose is 0.5 mg/10 kg body weight (single dose). As early symptoms, bradycardia and arrhythmia were observed, and less often tachycardia and increased blood pressure. If the overdose is severe, hypothermia, sweating, loss of consciousness, coma, or respiratory depression may occur. Adults: In adults, no overdose has been observed. In case of accidental ingestion, it is recommended to take activated charcoal and seek medical attention. Side effectsThe frequency of possible side effects listed below is defined as follows: very often (≥1/10) often (≥1/100 – <1/10) infrequently (≥1/1000 - <1/100) rarely (≥1/100) 10000 - <1/1000) very rarely (<1/10000) The frequency cannot be determined based on the available data: From the nervous system: - Rarely: headache, insomnia, fatigue. From the side of the cardiovascular system: - Infrequently: palpitations, rapid pulse, increased blood pressure. On the part of the respiratory system: - Often: burning and dryness of the nasal mucosa, after the cessation of the action of naphazoline, an increase in the feeling of "nasal congestion" caused by reactive hyperemia. - Uncommon: epistaxis. From the immune system: - Infrequently: allergic reactions (Quincke's edema, urticaria, itching). Prolonged or excessive use or the use of high doses of naphazoline may cause burning or dryness of the mucous membranes, as well as secondary (reactive) drug-induced rhinitis, which may occur after using naphazoline for more than 5 days. With prolonged use of naphazoline, damage to the epithelium of the mucous membrane may develop with inhibition of the activity of ciliary transport. In some cases, irreversible damage and dryness of the mucous membrane develop, which are characteristic of atrophic rhinitis. If side effects occur, you should consult your doctor about the advisability of further use of the drug. Storage conditions At a temperature not exceeding 25 ° C, in a place protected from light. Keep out of the reach of children! Buy Nafazolin-RUBICON nasal drops 1mg/ml 15ml №1 The price of Nafazolin-RUBICON nasal drops 1mg/ml 15ml №1