Chondromed Plus powder for solution for oral administration 600mg / 750mg in bags No. 30

Name:
Chondromed Plus por.d/prig.r-ra d/pr.vn.600mg/750mg pack in pack No. 30
Description:
White or white with a yellowish tint powder, odorless. The main active ingredient Chondroitin sulfate + glucosamine Release form Powder for solution for oral administration. Dosage 600mg / 750mg Pharmacodynamics The action of the drug Chondromed plus is due to its constituent components. Chondroitin sulfate is a mucopolysaccharide and one of the components of cartilage. It has a high ability to bind water, thus ensuring the mechanical and elastic properties of the cartilage. With degenerative processes in the joints, a decrease in the reserves of chondroitin sulfate in cartilage tissue is observed, caused by specific lytic enzymes. As a result of the loss of the ability to bind water, deterioration in cartilage degeneration and joint function progresses. Chondroitin sulfate inhibits cartilage-degrading elastase in vitro. The use of exogenous administration of chondroitin sulfate leads to the restoration of metabolic balance. Clinical efficacy: Clinical studies have shown that with the use of chondroitin sulfate, pain disappears or decreases and, in most cases, joint mobility improves. Glucosamine – administration of exogenous glucosamine provides non-specific protection against chemical damage to cartilage. Another possible action of glucosamine is the protection of damaged cartilage from metabolic destruction caused by non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids (GCS), as well as its own moderate anti-inflammatory effect. Pharmacokinetics Chondroitin sulfate: after oral administration, the maximum concentration of the drug in plasma is reached after 3-4 hours, in the synovial fluid – after 4-5 hours. Bioavailability is about 13%. More than 70% of chondroitin sulfate is absorbed in the digestive tract. Absorbed in the gastrointestinal tract, the drug accumulates in the synovial fluid. Excreted from the body by the kidneys. Glucosamine hydrochloride: rapidly absorbed in the small intestine. Bioavailability is 25-26% (due to the effect of “first pass” through the liver). After distribution in tissues, the highest concentrations are observed in the synovium, cartilage, liver and kidneys. Metabolized in the liver to form urea, water and carbon dioxide. It is excreted mainly in the urine unchanged, to a very small extent – with feces. The half-life is about 70 hours. Indications for use Symptomatic treatment of degenerative-dystrophic diseases of the joints and spine: stage I-III osteoarthritis, osteochondrosis. Method of administration and doses For oral administration. The contents of the sachet should be completely dissolved with stirring in a glass of water and drunk immediately after preparation. The use of warm water improves the dissolution process. Recommended to be taken with or immediately after a meal. Chondromed plus is prescribed for adults and children over 12 years old, 1 sachet 2 times a day (morning and evening) during the first month of admission; in the following days, 1 sachet 1 time per day. The minimum duration of treatment is 2 months. The optimal dosage regimen and the duration of the course of treatment is determined by the doctor. Use during pregnancy and lactation It is not recommended to use the drug during pregnancy and lactation due to the lack of data confirming the safety of its use in women during this period. Children The drug is not used in children under 12 years of age. Influence on the ability to drive a car and control mechanisms Chondromed plus does not affect the ability to drive vehicles and engage in potentially hazardous activities that require increased attention. Precautions Caution should be given to patients with bleeding, as well as patients with a tendency to bleeding. Caution should be exercised when prescribing to patients with severe renal and hepatic insufficiency. Interaction with other drugs With the simultaneous use of Chondromed Plus with other drugs, it is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics. With the combined use of Chondromed plus, it increases the absorption of tetracyclines, reduces the absorption of semi-synthetic penicillins, chloramphenicol. Compatible with non-steroidal anti-inflammatory drugs and glucocorticoids. When used together, it enhances the anti-inflammatory and analgesic effect of NSAIDs. Contraindications: individual intolerance (including a history of hypersensitivity) to the components of the drug; pregnancy and lactation; children under 12 years of age. Composition Active substances: chondroitin sulfate sodium salt – 600.0 mg; glucosamine hydrochloride – 750.0 mg. Excipients: anhydrous citric acid, fructose. Overdose In rare cases, symptoms of an overdose from the gastrointestinal tract are possible: nausea, vomiting, diarrhea; with prolonged use of excessively high doses, hemorrhagic rashes are possible. Treatment is symptomatic. Side effect On the part of the digestive system: in some cases – flatulence, diarrhea, constipation, epigastric pain. Allergic reactions: in some cases – urticaria, itching. Storage conditions In a place protected from moisture and light at a temperature not exceeding 25 oC. Keep out of the reach of children. Buy Chondromed Plus powder for oral solution 600mg / 750mg in bags #30 Price for Chondromed Plus powder for oral solution 600mg / 750mg in bags #30 in packages №30