Polfilin retard prolonged action tablets p/o 400mg №10×2

NamePolfilin retard tab. prolongation.dey-i p/o 400mg in pack. No. 10×2 The main active ingredient pentoxifylline Release form Tablets Dosage 400 mg if the side effect does not disappear, then pentoxifylline should be canceled. The drug should be used with caution in patients with cardiosclerosis and atherosclerosis of cerebral vessels, since they may experience angina pectoris, arterial hypotension and arrhythmia. With simultaneous use with anticoagulants, prothrombin time should be monitored. In patients with other risk factors for bleeding (for example, after surgery, erosive and ulcerative lesions of the gastrointestinal tract, hemorrhagic stroke, and retinal hemorrhage), it is recommended to monitor blood coagulation and periodically monitor hematocrit and hemoglobin concentration. The drug should be used with caution in patients with arterial hypertension or severe coronary artery disease, as this can lead to a sharp decrease in blood pressure and to a decrease in myocardial blood supply. In experimental studies, no mutagenic and carcinogenic effects of the drug were found. Pediatric Use The efficacy and safety of pentoxifylline in patients under 18 years of age have not been established. Influence on the ability to drive vehicles and control mechanisms Pentoxifylline can cause side effects from the central nervous system (dizziness). Therefore, the patient should be informed about the possible dangers associated with driving vehicles and servicing moving mechanisms. Indications for use Auxiliary treatment for: intermittent claudication due to atherosclerosis (the drug should be prescribed in combination with other methods of treatment, such as surgery, weight loss of the patient, exercise, smoking cessation); passing ischemia of the brain; hearing disorders caused by hypoxia; Meniere’s disease. Dosage and administration Tablets are taken after meals with plenty of water. Tablets are taken without chewing; they can only be divided. Adults are prescribed 400 mg 3 times / day. In patients with creatinine clearance less than 10 ml / min and in patients with severely impaired liver function, the daily dose of the drug should be reduced. Application during pregnancy and lactation Pentoxifylline passes through the placental barrier. No controlled trials have been conducted with the use of pentoxifylline during pregnancy. During pregnancy, the drug should be taken only if the potential benefit to the mother outweighs the risk to the fetus. Pentoxifylline and its metabolites are excreted in breast milk. During the treatment period, breastfeeding should be discontinued. Interaction with other drugs Pentoxifylline may increase the effect of drugs used to treat arterial hypertension, so the dose of these drugs should be reduced when used simultaneously. Cimetidine increases the concentration of pentoxifylline in the blood serum, which may increase its side effects with the simultaneous use of drugs. Sympathomimetic agents or xanthine derivatives, when used simultaneously with pentoxifylline, can lead to increased CNS excitation. Oral anticoagulants, coumarin, indandione derivatives, heparin and other drugs that affect the blood coagulation system (for example, cefamandol, cefoperazone, cefoletan, plicamycin, valproic acid), as well as thrombolytic agents and drugs that inhibit platelet aggregation, may increase the risk of bleeding. Patients taking these drugs at the same time should be closely monitored (monitoring of the prothrombin time is also recommended). Antacids containing aluminum or magnesium hydroxide do not significantly affect the absorption of pentoxifylline. These drugs can be used during treatment with pentoxifylline in order to reduce the side effects on the gastrointestinal tract caused by the drug. Contraindications risk of bleeding, especially after a recent hemorrhagic stroke, retinal hemorrhage; acute myocardial infarction; severe arrhythmia; pregnancy; lactation period (breastfeeding); age up to 18 years; increased individual sensitivity to pentoxifylline or methylxanthines (caffeine, theophylline, theobromine). Composition Pentoxifylline 400 mg Excipients: hydroxypropyl methylcellulose, Eudragit RL 100, Eudragit L 100, magnesium stearate, talc. Shell composition: hydroxypropyl methylcellulose, polyethylene glycol 6000, titanium dioxide, talc. Overdose Cases of pentoxifylline poisoning have been described in both adults and children. Symptoms of drug intoxication depend on its dose. In 44 patients who took high doses of pentoxifylline, the symptoms of acute poisoning were usually noted after 4-5 hours from the moment of taking the drug and persisted for 12 hours. The highest accepted dose of the drug was 80 mg / kg. Symptoms: flushing of the skin of the face, arterial hypotension, convulsions, drowsiness, loss of consciousness, fever and agitation. One patient who deliberately took pentoxifylline at a dose of 4-6 g developed severe bradycardia (30-40 beats / min), 1st degree AV block (lasting for 18 hours from the moment of drug poisoning) and 2nd degree AV block , hypokalemia, epigastric pain, nausea, vomiting and severe agitation. Treatment: There is no specific antidote. In case of overdose, gastric lavage should be carried out and symptomatic treatment should be started. To remove unabsorbed pentoxifylline, the appointment of activated charcoal is indicated. It is necessary to ensure the maintenance of vital functions of the body. In patients who are unconscious or convulsive, with no gag reflex, gastric lavage can be performed after intubation. Side effects In phase III clinical trials, the following side effects were noted: From the side of the cardiovascular system: 0.3% – angina pectoris, chest pain. From the digestive system: bleeding, flatulence, belching, dyspepsia (2.8%), nausea (2.2%), vomiting (1.2%). From the side of the central nervous system: dizziness (1.9%), headache (1.2%), tremor (0.3%). Other side effects (<1% of cases): From the side of the cardiovascular system: shortness of breath, edema, hypotension, cardiac arrhythmias. From the digestive system: lack of appetite, inflammation of the gallbladder, constipation, dry mouth, thirst. From the side of the central nervous system: anxiety, disorientation, depression, convulsions. From the senses: blurred vision, conjunctivitis, ear pain, visual field defects. Allergic reactions: skin rash, itching, urticaria, angioedema. Other: nosebleeds, flu-like symptoms, pharyngitis, hyperemia of the mucous membranes, increased fragility of the nails. Storage conditions The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25°C. Buy Polfilin retard long-acting tablets p/o 400mg №10x2 Price for Polfilin retard long-acting tablets p/o 400mg №10x2