Piracetam capsules 400mg №10×3

Name:
Piracetam capsules 400mg.
Description:
Hard gelatin capsules, number 0, white. The main active ingredient is Piracetam. Release formCapsules. Dosage 400mg. Pharmacological action Piracetam is a nootropic agent that improves cognitive functions. It improves microcirculation by affecting the rheological characteristics of the blood and does not cause a vasodilating effect. Piracetam has a protective and restorative effect in case of impaired brain function due to hypoxia, intoxication or trauma. Piracetam is used in the treatment of cortical myoclonus as monotherapy or in combination with antimyoclonic agents. Indications for use Piracetam is indicated for the symptomatic treatment of memory disorders, intellectual impairment in the absence of a diagnosis of dementia (symptomatic treatment of chronic psychoorganic syndrome). Piracetam may reduce the manifestations of cortical myoclonus. To determine the effect of piracetam in a patient with cortical myoclonus, a trial course of treatment is necessary. Dosage and administration Inside for adults (during meals or on an empty stomach, drinking liquid). The last dose is taken no later than 17.00 h (to prevent sleep disturbance). The daily dose is divided into 2-4 doses. Symptomatic treatment of psychoorganic syndrome: 4.8 g/day during the first week, then switch to a maintenance dose of 1.2-2.4 g/day. Treatment of cortical myoclonus begins with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until a maximum dose of 24 g / day is reached. Treatment is continued throughout the entire period of the disease. Every 6 months, you should try to reduce the dose or stop taking the drug, gradually reducing the dose by 1.2 g / day every 2 days. With a slight therapeutic effect or its absence, treatment is stopped. Since piracetam is excreted from the body by the kidneys, when prescribing the drug to patients with renal insufficiency and elderly patients, the dose should be adjusted depending on the value of creatinine clearance (CC). Patients with renal insufficiency require dose adjustment of the drug in accordance with the following scheme: Degree of renal insufficiency – CC (ml / min) – Dose Normal – > 80 – Usual dose Light – 50–79 – 2/3 of the usual dose in 2-3 doses Moderate – 30-49 – 1/3 usual dose in 2 doses Severe – < 30 - 1/6 usual dose, single dose End stage - Contraindicated In elderly patients, the dose is adjusted in the presence of renal insufficiency; with prolonged therapy, it is necessary to monitor the functional state of the kidneys. Patients with impaired liver function do not require dose adjustment. For patients with impaired function of both the kidneys and the liver, the drug is prescribed in the same way as for patients with impaired renal function only. Use during pregnancy and lactation Controlled studies of the use of the drug during pregnancy have not been conducted. Piracetam crosses the placental barrier and into breast milk. The concentration of the drug in newborns reaches 70-90% of its concentration in the blood of the mother. You should refrain from breastfeeding when prescribing piracetam to a woman. Influence on the ability to drive a car and potentially dangerous mechanisms During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Precautions Due to the effect of piracetam on platelet aggregation, caution should be exercised when prescribing the drug to patients with impaired hemostasis, bleeding symptoms, before an upcoming surgical intervention, previous surgery (including dental), risk factors for bleeding (for example, gastric ulcer and duodenal ulcer), previous intracerebral hemorrhage, taking anticoagulants or antiplatelet agents, including low doses of aspirin. In the treatment of cortical myoclonus, abrupt discontinuation of treatment should be avoided, as this may cause the resumption of seizures. With long-term therapy in elderly patients, regular monitoring of renal function is recommended, if necessary, dose adjustment is carried out depending on the CC. Penetrates through the filtering membranes of hemodialysis machines. Application in children. The use of the drug in children under 18 years of age is not recommended. Interaction with other drugs The possibility of changing the pharmacokinetics of piracetam under the influence of other drugs is low, since 90% of piracetam is excreted unchanged in the urine. With simultaneous use with thyroid hormones, there have been reports of confusion, irritability and sleep disturbance. According to a study of patients with recurrent venous thrombosis, piracetam at a dose of 9.6 g / day increases the effectiveness of indirect anticoagulants (there was a more pronounced decrease in platelet aggregation, fibrinogen concentration, von Willebrand factors, blood and plasma viscosity compared with the use of acenocoumarol alone). At concentrations of 142, 426 and 1422 µg/ml, piracetam does not inhibit cytochrome P450 isoenzymes. For a concentration of 1422 µg/ml, minimal inhibition of CYP 2A6 (21%) and 3A4/5 (11%) was observed. However, normal inhibition constants can probably be achieved at higher concentrations. Thus, the metabolic interaction of piracetam with other drugs is unlikely. Taking piracetam at a dose of 20 g / day for 4 weeks did not change the maximum serum concentration and the area under the concentration-time curve of antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, valproate) in patients with epilepsy who received piracetam at a stable dose. Co-administration with alcohol did not affect the concentration of piracetam in serum? and the concentration of ethanol in the blood serum did not change when taking 1.6 g of piracetam. Contraindications Individual intolerance to piracetam or pyrrolidone derivatives, as well as other components of the drug; psychomotor agitation at the time of drug administration; chorea of Huntington; acute violation of cerebral circulation (hemorrhagic stroke); terminal stage of chronic renal failure (with creatinine clearance less than 20 ml/minute); pregnancy, lactation period. Composition Each capsule contains: active substance: piracetam - 400 mg; excipients: calcium stearate; magnesium carbonate basic, light. The composition of the hard gelatin capsule: gelatin, glycerin, purified water, titanium dioxide E 171, sodium lauryl sulfate. OverdoseSymptoms: abdominal pain, diarrhea mixed with blood. Treatment: induction of vomiting, gastric lavage, symptomatic therapy, hemodialysis (effectiveness 50-60%). There is no specific antidote. Side effects From the nervous system: mental agitation, motor disinhibition, irritability, imbalance, decreased ability to concentrate, anxiety, insomnia or drowsiness, depression, ataxia, dizziness, headache, exacerbation of epilepsy, anxiety, hallucinations, confusion, extrapyramidal disorders (including hyperkinesis), convulsions, tremor. From the senses: vertigo. From the side of the cardiovascular system: arterial hypo- or hypertension is possible, in elderly patients - exacerbation of coronary insufficiency, worsening of the course of angina pectoris. From the blood and lymphatic system: blood clotting disorders. From the digestive system: gastralgia, nausea, vomiting, diarrhea. Allergic reactions: hypersensitivity, anaphylactic reactions, dermatitis, itching, rash, urticaria, angioedema. Other: increased sexual activity, weight gain, asthenia, fever. Storage conditions Store in a place protected from moisture and light at a temperature not exceeding 25 ° C. Buy Piracetam capsules 400mg №10x3 Price for Piracetam capsules 400mg №10x3Instruction for use for Piracetam capsules 400mg №10x3