Papaverine rectal suppositories 20mg №5×2

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Papaverine supp. rect. 20 mg in a cell. pack No. 5×2
Description:
Cylindroconical suppositories, white or white with a yellowish tint. On the cut, the presence of an airy, porous rod and a funnel-shaped depression is allowed. The main active ingredient is papaverine hydrochloride. Release form Rectal suppositories Dosage 20 mg Pharmacological action Drugs for the treatment of functional disorders of the gastrointestinal tract. Papaverine and its derivatives. ATX code: A03A D01. Pharmacodynamics Papaverine hydrochloride reduces the tone of smooth muscles and therefore has a vasodilating and antispasmodic effect. The effect of papaverine hydrochloride on the central nervous system is weak, only in large doses, it has some sedative effect. In large doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction. Mechanism of action. It is an inhibitor of the enzyme phosphodiesterase and causes intracellular accumulation of cyclic 3,5-adenosine monophosphate, which leads to impaired contractility of smooth muscles and their relaxation in spastic conditions. Pharmacokinetics Absorption of papaverine depends on the dosage form. Bioavailability on average – 54%. Communication with blood plasma proteins – 90%. It is well distributed, gets through gistogematichesky barriers. Metabolized in the liver. The half-life (T?) – 0.5-2 hours (may be extended up to 24 hours). Excreted by the kidneys as metabolites. Completely removed from the blood during hemodialysis. Indications for use Spasm of smooth muscles of the abdominal organs (cholecystitis, pylorospasm, spastic colitis, renal colic). Method of administration and doses The use of this medicinal product is possible only after consulting a doctor! Rectally. The suppository is introduced into the anus (after a cleansing enema or spontaneous bowel movement), after releasing the suppository from the contour package with scissors (cutting the package along the contour of the candle). Apply 1-2 suppositories 2-3 times a day. Instructions for rectal administration of the drug When using rectal suppositories, abdominal cramps and the urge to defecate often occur, so before the procedure, perform a cleansing enema or empty the intestines naturally. Wash your hands thoroughly with soap. Prepare wet wipes or a handkerchief soaked in water in advance. Lie on your side with your knees pressed to your stomach. For the procedure, this position is the most convenient, as it allows you to minimize discomfort. Release the candle from the contour packaging with scissors (cutting the packaging along the contour of the candle). The candle is taken with the thumb and middle fingers of the right hand in the middle of the widest part, the index finger rests on the blunt end of the candle. The candle is directed with the free end to the anus and pushed with the index finger into the anal canal until it is completely immersed to a depth of 2-3 cm. Carry out the procedure carefully, without exerting excessive pressure. Despite the fact that the suppository has a streamlined shape, careless use can injure the mucous membrane. Do not get out of bed for about 20 minutes. Wipe your hands with a pre-prepared damp cloth or handkerchief. If within 10 minutes after the introduction of a rectal suppository there is an urge to defecate, empty the intestines and introduce a new suppository. If more than 10 minutes have passed between the introduction of the suppository and a bowel movement, an additional dose of the drug is not required. Use during pregnancy and lactation If you are pregnant or breastfeeding, if you suspect that you are pregnant or do not exclude the possibility of pregnancy, inform your doctor. During pregnancy and lactation, the safety of the drug has not been established, so use with caution. Precautions With caution and in small doses, the drug should be prescribed to elderly and debilitated patients, as well as patients with traumatic brain injury, impaired liver or kidney function, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, as well as patients with supraventricular tachycardia and who are in a state of shock. During the period of treatment, alcohol should be excluded. When smoking, the vasodilating effect of papaverine decreases. Pregnancy and lactation Care should be taken during pregnancy and lactation. Influence on the ability to drive vehicles and manage potentially dangerous mechanisms When taken in therapeutic doses, the drug does not affect the ability to drive a car or other potentially dangerous mechanisms. Interaction with other drugs If you are currently or have recently taken other drugs, tell your doctor. It is not prescribed in conjunction with β-adrenergic agents (causes a risk of arrhythmias). Papaverine may enhance the hypotensive effect of antihypertensive drugs. The effects of papaverine are potentiated by anesthetic, analgesic, sedative and tranquilizing substances. When used together with tricyclic antidepressants, procainamide, reserpine, quinidine, the hypotensive effect of papaverine may be enhanced. Papaverine reduces the effects of dopegyt and levodopa. Nicotine (smoking) reduces the effectiveness of papaverine. The antispasmodic effect of papaverine is enhanced by diphenhydramine (diphenhydramine), metamizole (analgin), diclofenac. With simultaneous use with cardiac glycosides, a pronounced increase in the contractile function of the myocardium is observed due to a decrease in the total peripheral vascular resistance. When used with novocainamide, an increase in the hypotensive effect is possible. There is evidence of the development of hepatitis when combined with furadonin. Papaverine hydrochloride potentiates the effect of alcohol. Pharmaceutically compatible with Dibazol. Contraindications Hypersensitivity to the components of the drug, inflammatory processes of the rectum, coma, respiratory depression, broncho-obstructive syndrome, AV conduction disorders, atrioventricular blockade, glaucoma, severe liver failure, old age (risk of hyperthermia), children’s age (up to 18 years). Composition 1 suppository contains: active substance: papaverine hydrochloride 20 mg, excipients: semi-synthetic glycerides (suppocir AM (solid fat)). OverdoseSymptoms: blurred vision, diplopia, weakness, dry mouth, redness of the skin of the upper body, hyperventilation, nystagmus, ataxia, tachycardia, asystole, ventricular flutter, collapse, arterial hypotension, drowsiness, headache, nausea, constipation, excessive sweating, allergic reactions. In case of accidental intake of very large doses of papaverine, the toxic effect of the drug in the form of arrhythmias, complete or partial atrioventricular blockade is possible. Treatment: drug withdrawal, symptomatic therapy. There is no specific antidote. Completely removed from the blood during hemodialysis. Side effects On the part of the skin and subcutaneous tissue: allergic reactions, skin hyperemia, urticaria, itching, skin rashes, reactions at the injection site. From the hematopoietic system: eosinophilia. From the side of the cardiovascular system: blockade, arrhythmia, ventricular fibrillation, ventricular extrasystole, tachycardia, asystole, ventricular flutter, collapse, arterial hypotension. From the nervous system: drowsiness, weakness, headache, dizziness, apnea. On the part of the organ of vision: visual impairment (diplopia). From the gastrointestinal tract: increased activity of hepatic transaminases, nausea, diarrhea, constipation, anorexia, dry mouth. Other: increased sweating. If side effects occur, tell your doctor about it. This applies to all possible side effects, including those not described in this package insert. Storage conditionsStore in a dry, dark place at temperatures between 15°C and 25°C. Keep out of the reach of children! Buy Papaverine rectal suppositories 20mg No. 5×2 Price for Papaverine rectal suppositories 20mg No. 5×2