Mikanisal shampoo 20mg/g 60g №1

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Mikanisal shampoo 20mg/g in a bottle 60g in a pack №1
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Transparent or almost transparent from light pink to dark red viscous mass or liquid, with a specific smell. The main active ingredient Ketoconazole Release form 60 g or 100 g of shampoo in a plastic bottle. 1 plastic bottle in a cardboard box along with instructions for use. Dosage 20mg/g in vial 60g in pack No. 1 PharmacodynamicsKetoconazole, a synthetic derivative of imidazoledioxolane, has antifungal activity against dermatophytes such as Trichophyton spp., Epidermophyton spp., Microsporum spp., and yeasts such as Candida spp. and Malassezia spp. (Pityrosporam spp.). Pharmacological properties are due to the ability to damage the cell membranes of fungi by inhibiting cytochrome P450-dependent 14?-demethylase, which catalyzes the conversion of lanosterol to ergosterol, the main structural component of the fungal membrane. Pharmacokinetics Since the shampoo is absorbed through the skin in small quantities (also after prolonged use), a systemic effect is unlikely. Indications for useTreatment and prevention of infections caused by the yeast Malassezia spp. (Pityrosporum spp.), such as seborrheic dermatitis (dandruff). Dosage and administration Externally. Adults Treatment: twice a week for 2-4 weeks. Prevention: once a week or every other week. For a single wash, 5-6 ml (1 teaspoon) of shampoo with a little water should be carefully applied to the affected skin and hair. Shampoo should be left for 3-5 minutes, then rinse with water. Rinse should not only hair, but also the scalp. Children Experience in children and adolescents under 18 years of age is limited. Precautions The use of the drug in children and adolescents (under 18 years of age) is not recommended, since there are insufficient data on the use in this age group of people. As with other shampoos, avoid getting shampoo on wounds and eyes. If this does happen, you should immediately rinse your eyes with water. Seborrhea and dandruff, which are the reason for the use of shampoo, are often associated with hair loss. Hair loss is also possible with MICANISAL® Shampoo 20 mg/g. The shampoo contains azorubin dye, which can cause allergic reactions. Pregnancy and lactation Ketoconazole was not detected in plasma even after prolonged use. MICANISAL® Shampoo 20 mg/g can be used during pregnancy and lactation. If you are pregnant or breastfeeding, if you think you are pregnant or do not rule out the possibility of pregnancy, tell your doctor. Influence on the ability to drive vehicles and maintain moving mechanisms There is no effect. Interaction with other drugs No interactions with other drugs have been observed with topical application of ketoconazole. When using the shampoo immediately after prolonged topical use of potent glucocorticosteroids, symptoms of skin irritation may occur. To avoid this, it is desirable to continue treatment with low-potency glucocorticosteroids and complete treatment gradually over 2-3 weeks. Shampoo can be used 3 weeks after cessation of local treatment with glucocorticosteroids. Treatment should not be interrupted suddenly, also if more than 3 weeks of treatment with oral corticosteroids was carried out at the same time; therapy should be interrupted gradually. Storage conditions and shelf life Store at a temperature not exceeding 25 °C. Do not freeze. Keep out of the reach of children. Shelf life – 2 years. Do not use after the expiry date stated on the packaging. Contraindications Hypersensitivity to the active substance or to any excipient of the drug. Composition 1 g of shampoo contains: active substance: 20 mg of ketoconazole; excipients: sodium laureth sulfate, disodium laureth sulfosuccinate, coconut oil fatty acid diethanolamide, lauryldimonium hydroxypropylcollagen hydrolyzate, macrogol methyldextrose dioleate, sodium chloride, sodium hydroxide, concentrated hydrochloric acid, imidazolidinyl urea, azorubine dye, purified water. Overdose With topical application of shampoo containing ketoconazole, overdose is unlikely. Accidental ingestion of shampoo is not generally life-threatening. Only supportive treatment is needed. To avoid getting the shampoo into the respiratory tract, it is not recommended to induce vomiting or do a gastric lavage. Side effects Side effects are presented by MedDRA system organ classes using the MedDRA classification by frequency of manifestation: very often (≥1/10); often (from? 1/100 to <1/10); infrequently (from? 1/1000 to <1/100); rarely (from? 1/10,000 to <1/1000); very rarely (<1/10,000); unknown (cannot be estimated from available data). Infections and infestations Uncommon: folliculitis. Very rare: rhinitis. Immune system disorders Uncommon: hypersensitivity. Very rare: angioedema, urticaria. Metabolic and nutritional disorders Very rare: loss of appetite. Nervous system disorders Uncommon: taste disturbances. Very rare: paresthesia. Eye damage Infrequently: eye irritation, increased tearing. Very rare: tingling in the eyes. Damage to the skin and subcutaneous tissue Common: itching and burning sensation, dry skin, changes in hair texture. Infrequently: seborrhea / acne, telangiectasia, hair loss (alopecia), erythematous rash, contact dermatitis, skin peeling. Rarely: hair becomes excessively greasy or dry. Very rare: change in hair color (especially in patients with chemically damaged or gray hair), reddening of the face. General disorders and reactions at the site of application Often: reactions at the site of application, pustules at the site of application. Infrequently: symptoms of irritation at the site of application, erythema and itching at the site of application. Very rare: scalp sensitivity, scalp irritation. Storage conditionsStore at a temperature not exceeding 25 °C. Do not freeze. Keep out of the reach of children. Shelf life - 2 years. Do not use after the expiry date stated on the packaging. Buy Mikanisal shampoo 20mg/g 60g №1