Liprimar tablets p/o 10mg №10×3

NameLiprimar. Forms of release Tablets. MNNA torvastatin. Pharmacotherapeutic group ATC code – С10АА05 Hypolipidemic agents. HMG-CoA reductase inhibitors. What is Liprimar and when is this drug used? Liprimar belongs to a group of drugs called statins, which regulate the level of lipids (fats) in the blood. Liprimar is used to lower blood lipids such as cholesterol and triglycerides when a low-fat diet and lifestyle changes alone have not been effective. Liprimar can also be used to reduce the risk of heart disease even when cholesterol levels are normal. During treatment with Liprimar, it is necessary to follow a standard diet aimed at lowering cholesterol levels. Do not take this medicine if you are hypersensitive (allergic) to atorvastatin or any of the other ingredients of this drug (listed in the Composition section); – if you have had or are currently suffering from a disease that causes liver dysfunction; – if you have unexplained pathological abnormalities in the biochemical indicators of liver function; – if you are a woman of reproductive age who does not use reliable contraception; – if you are pregnant or plan to become pregnant; – if you are breastfeeding. – if you are taking glecaprevir/pibrentasvir in the treatment of hepatitis C. Indications and precautions Talk to your doctor, pharmacist or nurse before taking Liprimar: – if you have severe respiratory failure. – if you are taking or have taken in the past 7 days a medicine called fusidic acid (used to treat a bacterial infection) by mouth or by injection. The combined use of fusidic acid and Liprimar can lead to serious muscle problems (rhabdomyolysis). – if you have had a hemorrhagic stroke in the past or if you have small cysts in the brain due to previous strokes; – if you have kidney problems; – if you have an underactive thyroid gland (hypothyroidism); – if you have recurring or unexplained muscle pain or have had muscle problems in your family; – if you have previously developed muscle problems while taking other lipid-lowering drugs (for example, other statins or fibrates); – if you regularly consume alcohol in large quantities; – if you have a history of liver disease; – if you are over 70 years old. If any of the above conditions apply to you, your doctor will need to order a blood test before you start using the drug Liprimar and possibly during treatment to determine the possibility of you developing adverse reactions due to muscle disorders. It is known that the risk of developing side effects associated with muscles (for example, rhabdomyolysis) increases with the simultaneous use of certain drugs (see section “Other drugs”). Also tell your doctor or pharmacist if you have persistent muscle weakness. Additional examinations and drugs for diagnosis and treatment may be required. If you have diabetes or are at risk of developing diabetes, you will be under close medical supervision during treatment with this medicine. If you have high blood sugar and fat levels, if you are overweight and have high blood pressure, you are more likely to develop diabetes. Liprimar contains lactose Talk to your doctor before taking this medicine if your doctor has previously told you that you have an intolerance to some sugars. Other medicines Tell your doctor or pharmacist if you are currently taking, have recently taken or may take any other medicines. Some drugs may change the way Liprimar works or Liprimar may affect how these drugs work. This type of interaction may reduce the effectiveness of one or both drugs, and may increase the risk of or severity of adverse reactions, including a serious muscle wasting condition called rhabdomyolysis, which is described in the section “What side effects may occur”: – drugs that affect the immune system (for example, cyclosporine); – certain antibiotics or antifungals (eg erythromycin, clarithromycin, telithromycin, ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole, rifampin, fusidic acid); – other drugs that affect lipid levels (eg gemfibrozil, other fibrates, colestipol); – some calcium channel blockers used to treat angina or high blood pressure (eg amlodipine, diltiazem); medicines for the treatment of cardiac arrhythmias (eg, digoxin, verapamil, amiodarone); – medicines for the treatment of HIV infection (eg ritonavir, lopinavir, atazanavir, indinavir, darunavir, tipranavir/ritonavir combination, etc.); – some medicines used to treat hepatitis C (eg telaprevir, boceprevir and elbasvir/grazoprevir combination); – other medicines known to interact with Liprimar: ezetimibe (lowers cholesterol), warfarin (lowers blood clotting), oral contraceptives, styripentol (an anticonvulsant used to treat epilepsy), cimetidine (used to treat heartburn) and peptic ulcers), phenazone (a pain reliever), colchicine (used to treat gout), and antacids (medications for indigestion containing aluminum or magnesium); – medicines sold without a doctor’s prescription: preparations containing St. John’s wort. – if you need to take fusidic acid by mouth to treat a bacterial infection, you should temporarily stop taking this medicine. Your doctor will tell you when it is safe to start taking Liprimar again. Taking Liprimar together with fusidic acid can, in rare cases, lead to muscle weakness, muscle soreness when touched, or pain (this phenomenon is called “rhabdomyolysis”). For more information about rhabdomyolysis, see the section “Side Effects You May Have”. The effect of food and drink intake on the drug Liprimar Instructions for taking the drug Liprimar are given in the “How to take” section. Please note the following: Grapefruit juice Do not drink more than one or two small glasses of grapefruit juice per day, as large amounts of grapefruit juice may affect the effect of Liprimar. Alcohol Do not drink large amounts of alcohol while taking this drug. For details, see the “Instructions and Precautions” section. Pregnancy and breastfeeding Do not take Liprimar if you are pregnant or planning to become pregnant. You should not take Liprimar if you are able to become pregnant and are not using reliable methods of contraception. You should not take Liprimar if you are breastfeeding. The safety of Liprimar during pregnancy and lactation has not been established. Before using any medicine, consult your doctor or pharmacist. Driving and using machines Generally, this drug does not affect the ability to drive or use machines. However, do not drive a car if this drug affects your ability to drive. Do not use any tools or equipment if this drug affects your ability to do these things. How to take Before starting treatment, your doctor will prescribe you a low cholesterol diet, which you will need to follow while taking Liprimar. The standard starting dose of Liprimar is 10 mg once daily in adults and children 10 years of age and older. If necessary, your doctor may increase the dose of the drug until you receive the dose that you need. Dose adjustments will be made by the attending physician at intervals of 4 weeks or more. The maximum dose of Liprimar is 80 mg once daily. Liprimar tablets should be swallowed whole with water. The drug Liprimar can be taken at any time of the day, regardless of the meal. However, try to take your tablets at the same time each day. In all cases, you should strictly follow the instructions of the doctor or pharmacist. If you have any doubts about taking the medicine, ask your doctor or pharmacist for advice. The duration of taking the drug Liprimar is determined by your doctor. Talk to your doctor if you feel that the effect of Liprimar is too strong or too weak. If you have taken more Liprimar tablets than you should If you have accidentally taken too many Liprimar tablets (more than your usual daily dose), contact your doctor or the nearest hospital. If you forget to take Liprimar If you miss one dose of the drug, take the next dose according to your usual schedule at the proper time. Do not take a double dose to make up for a missed dose. If you want to stop taking Liprimar, if you have any further questions about the use of this medicine or if you want to stop treatment, ask your doctor or pharmacist. What side effects you may get Like all medicines, this medicine can sometimes have side effects, although not everybody gets them. If you notice any of the following serious side effects, stop taking the drug and tell your doctor immediately or go to the nearest hospital or emergency room. Rare: may affect up to 1 in 1,000 people. – Serious allergic reactions with swelling of the face, tongue and throat, which can cause severe difficulty in breathing. – Serious skin lesions with severe flaking and swelling, blistering of the skin, mouth, eyes, genitals and fever. A rash on the skin in the form of pink-red spots, especially on the palms of the hands or soles of the feet, which may turn into blisters. – Muscle weakness, soreness or pain in the muscles, especially if accompanied by poor health and high body temperature. This condition may be due to the pathological destruction of muscle tissue. Pathological destruction of muscle tissue does not always resolve on its own, even after discontinuation of atorvastatin, can be life-threatening and can lead to impaired renal function. Very rare: may affect up to 1 in 10,000 people. – Unexpected or unusual bleeding or hemorrhage, which may indicate a liver problem. You should consult with your doctor as soon as possible. Other possible side effects of the drug Liprimar Frequent: sinus inflammation, sore throat, nosebleeds may occur in 1 in 10 people; allergic reactions; increased blood glucose levels (if you are diabetic, continue careful monitoring of blood glucose levels), increased blood creatine kinase levels; headache; nausea, constipation, flatulence, indigestion, diarrhea; joint pain, muscle pain, and back pain; deviations in the results of a blood test, indicating a possible violation of liver function. Uncommon: may affect up to 1 in 100 people with anorexia (loss of appetite), weight gain, low blood glucose (if you have diabetes, keep monitoring your blood glucose closely); nightmares, insomnia; dizziness, numbness or tingling in the fingers and toes, decreased sensation of pain or touch, change in taste perception, memory loss; blurred vision; ringing in the ears and / or head; vomiting, belching, pain in the upper and lower abdomen, pancreatitis (inflammation of the pancreas causing pain in the abdomen); hepatitis (inflammation of the liver); rash, skin rash and itching, hives, hair loss; neck pain, muscle fatigue; fatigue, feeling unwell, weakness, chest pain, swelling, especially in the ankles (edema), fever; a positive test result for the presence of leukocytes in the urine. Rare: may affect up to 1 in 1,000 people with visual impairment; unexpected bleeding or bruising; cholestasis (yellowing of the skin and mucous membranes of the eyes); tendon injury. Very rare: may affect up to 1 in 10,000 people with an allergic reaction – symptoms may include sudden shortness of breath, pain or tightness in the chest, swelling of the eyelids, face, lips, mouth, tongue and throat, difficulty breathing, fainting; hearing loss; gynecomastia (enlargement of the mammary glands in men and women). Not known: frequency cannot be estimated from the available data: persistent muscle weakness. Possible side effects reported with the use of some statins (drugs of the same type): sexual dysfunction; depression; breathing problems, including persistent cough and/or shortness of breath or fever; diabetes mellitus, the development of which is most likely with an increase in the level of glucose and fats in the blood, overweight and high blood pressure. Your doctor will monitor your health while you are taking this drug. Providing information about side effects If you notice the appearance of side effects, incl. not listed in this leaflet, please tell your doctor or pharmacist. By reporting side effects, you help to gather information about the safety of this medicine. How to store Keep out of the reach of children. Store at a temperature not exceeding 25°C. Do not use the drug after the expiration date indicated on the carton or on the blister after the word “EXP”. The expiry date is the last day of the specified month. Medicines should not be thrown into the sewer or with household waste. For instructions on handling unused medicines, contact your pharmacist. These measures will help protect the environment. Composition 1 coated tablet contains: active substance: atorvastatin calcium in an amount equivalent to 10, 20 and 40 mg of atorvastatin. excipients: calcium carbonate (E170), microcrystalline cellulose (E460), lactose monohydrate, croscarmellose sodium, polysorbate 80 (E433), hydroxypropylcellulose (E463), magnesium stearate (E470), Opadray white YS-1-7040, simethicone emulsion. Appearance of the drug and contents of the package White round-shaped film-coated tablets, engraved with “10”, “20”, or “40” (corresponding to the dosage) on one side and “ATV” on the other side. Coated tablets 10, 20 or 40 mg: 2 blisters of 7 tablets or 3 blisters of 10 tablets, together with instructions for use in a cardboard box. Terms of dispensing from pharmacies By prescription. Buy Liprimar tablets p/o 10mg No. 10×3