Arpetol tablets p/o 50mg №10×2

Name:
Arpetol tab p / o 50 mg cont cell pack No. 10×2
Description:
Film-coated tablets, white, with a biconvex surface. The main active ingredient Umifenovir (Umifenovir) Release form Film-coated tablets Dosage 50 mg Pharmacological action Pharmacodynamics Antiviral agent, has an immunomodulatory and anti-influenza effect, specifically suppresses type A and B viruses, coronavirus associated with severe acute respiratory syndrome (SARS). Interferes with contact and penetration of viruses into a cell, suppressing merge of a lipidic cover of a virus with cellular membranes. It has an interferon-inducing effect, stimulates humoral and cellular immune responses, the phagocytic function of macrophages, and increases the body’s resistance to viral infections. Reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and a reduction in the duration of the disease. Refers to low-toxic drugs. It does not have any negative effects on the human body when taken orally at recommended doses. Pharmacokinetics Rapidly absorbed and distributed to organs and tissues. The maximum plasma concentration when taken at a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg – after 1.5 hours. It is metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in a small amount by the kidneys (0.12%). During the first day, 90% of the administered dose is excreted. Indications for use Prevention and treatment in adults and children: influenza A and B, other SARS; Complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years. Complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection. Prevention of postoperative infectious complications. Dosage and administration Before using the medicine, consult with your doctor. Inside, before meals. Single dose: children from 3 to 6 years old – 50 mg, from 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg). For non-specific prophylaxis In direct contact with patients with influenza and other acute respiratory viral infections: children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old and adults – 200 mg once a day within 10-14 days. To prevent exacerbations of chronic bronchitis, recurrence of herpes infection during an influenza epidemic and other acute respiratory viral infections: children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old and adults – 200 mg each twice a week for 3 weeks. For the prevention of severe acute respiratory syndrome (in contact with patients): children from 6 to 12 years old, 100 mg, adults and children over 12 years old, 200 mg once a day (before meals), for 12-14 days. Prevention of postoperative complications: children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old and adults – 200 mg 2 days before surgery, then on days 2 and 5 after surgery. For the treatment of influenza, other acute respiratory viral infections without complications: children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old and adults – 200 mg 4 times a day (every 6 hours ) within 5 days. Influenza, other acute respiratory viral infections with the development of complications (bronchitis, pneumonia, etc.): children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old and adults – 200 mg each 4 once a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks. Severe acute respiratory syndrome: children over 12 years of age and adults – 200 mg 2 times a day for 8-10 days. In the complex treatment of chronic bronchitis, herpes infection: children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old and adults – 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks. Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years old: children from 3 to 6 years old – 50 mg each, from 6 to 12 years old – 100 mg each, over 12 years old – 200 mg 4 times a day (every 6 hours) within 5 days. If you have any doubts or questions, please contact your doctor. Use during pregnancy and lactation In animal studies, no direct or indirect harmful effects on pregnancy, embryonic and fetal development, labor and postnatal development have been identified. Due to the lack of data on the efficacy and safety of the drug Arpetol in pregnant and lactating women, it is not recommended to take the drug during pregnancy and during breastfeeding. Precautions Use in children The use of the drug Arpetol in children under 6 years of age may be limited due to the possible lack of skill in swallowing tablets at this age. If the child does not have the ability to swallow tablets, Arpetol is recommended to be used under medical supervision due to the risk of tablet aspiration. This risk is associated with the immaturity of the swallowing reflex, which may occur in children under 6 years of age. Features of use in elderly patients Dose adjustment when using the drug in elderly patients is not required. Features of use in patients with impaired liver and kidney function The pharmacokinetics and safety of Arpetol in patients with impaired liver and kidney function have not been studied. The drug contains lactose, so it should not be taken by patients with rare hereditary forms of galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption syndrome. Impact on the ability to drive vehicles and mechanisms Does not show central neurotropic activity and can be used in medical practice in people of various professions, including those requiring increased attention and coordination of movements (transport drivers, operators, etc.). Interaction with other drugs When administered with other drugs, no negative effects were noted. Contraindications Hypersensitivity to the components of the drug, age up to 3 years. Composition Each tablet contains: umifenovir hydrochloride – 50 mg; excipients: povidone (K 17), microcrystalline cellulose, modified corn starch (Starch 1500), magnesium stearate, anhydrous colloidal silicon dioxide, lactose monohydrate, white opadra II (polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc). Overdose Not noted. Side effect Allergic reactions: rarely – rash, itching; very rarely – angioedema. From the gastrointestinal tract: very rarely – heartburn, nausea, vomiting, diarrhea. In the event of adverse reactions, including those not listed in this leaflet, you must stop taking the drug and consult a doctor. Storage conditions At a temperature not higher than 25 °C. Keep out of the reach of children. Buy Arpetol tablets p/o 50mg №10×2 Price for Arpetol tablets p/o 50mg №10×2