Sodium chloride injection isotonic 9mg/ml in ampoules 5ml №10

Name Sodium chloride solution dyn.iso.9mgml in amp.5ml in pack No. 10 Main active ingredientSodium chloride Form of release solution for infusion Dosage 9mgml in amp.5ml Pharmacological action Sodium and chloride ions are the most important inorganic components of the extracellular fluid that maintain the appropriate osmotic pressure of blood plasma and extracellular fluid. Isotonic sodium chloride solution has a plasma-substituting, detoxifying, hydrating effect, contributes to the normalization of the acid-base state. A 0.9% solution of sodium chloride is isotonic to human plasma, therefore it is quickly removed from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness in blood loss and shock is insufficient). Indications for use Plasma-isotonic fluid replacement, hypochloremic alkalosis, hyponatremia with dehydration, intoxication, dissolution and dilution of parenteral drugs (as a stock solution). Also, sodium chloride, a solution for infusion, is used to wash wounds, the conjunctiva of the eye, the abdominal and pleural cavities, the vagina, the bladder, and to moisten the dressing. Method of administration and doses Before administration, visually inspect the drug bottle, check the tightness of the package and the presence of the label. The solution must be clear, free of suspended particles or sediment. Intravenously (drip). Doses, speed and duration of use are selected individually depending on the indication for use, age, body weight, the patient’s condition and concomitant therapy, as well as the effectiveness of treatment in terms of general symptoms and laboratory parameters. Before the introduction of the solution is heated to 36-38°C. The dose is determined depending on the loss of body fluid, sodium and chlorine ions and averages 1000 ml / day as an intravenous continuous drip infusion at an injection rate of up to 180 drops / minute. With large fluid losses and severe intoxication, it is possible to administer up to 3000 ml / day. The rate of administration is 540 ml/h, if necessary, the rate of administration is increased. Children with a pronounced decrease in blood pressure against the background of dehydration (before determining laboratory parameters, namely: determination of sodium, potassium, chlorine in the blood and urine; study of acid-base balance: determination of residual nitrogen and creatinine concentration in the blood) are administered 20-30 mg / kg. In the future, the dosing regimen is adjusted depending on laboratory parameters. With prolonged administration of large doses of 0.9% sodium chloride solution, it is necessary to monitor plasma and urine. Application during pregnancy and lactation It is possible to use during pregnancy and during breastfeeding in cases where the expected benefit to the mother outweighs the possible risk of complications. Precautions When carrying out any infusion, it is necessary to monitor the patient’s condition, clinical and biological parameters, especially important to evaluate blood plasma electrolytes. In children, the immaturity of kidney function may slow sodium excretion. Therefore, in such patients, repeated infusions should be carried out only after determining the concentration of sodium in the blood plasma. If a hypersensitivity reaction or infusion reactions occur, the infusion should be stopped immediately and the necessary therapeutic measures taken according to the indications. Depending on the volume and rate of infusion against the background of intravenous administration of the drug, there may be a risk of developing hypervolemia and / or overload of dissolved substances and electrolyte imbalance. In patients with renal insufficiency, the drug should be used with extreme caution or not used at all. The use of the drug in such patients can lead to sodium retention. Use only a clear solution, without visible inclusions, and if the packaging is not damaged. Enter immediately after connecting to the infusion system. The solution should be administered using sterile equipment in compliance with the rules of asepsis and antisepsis. To prevent air from entering the infusion system, it should be filled with solution, releasing the residual air from the container completely. As with all parenteral solutions, the compatibility of the added substances with the solution must be determined before reconstitution. Medicinal products known to be incompatible with 0.9% sodium chloride should not be used with 0.9% sodium chloride solution. The compatibility of the added medicinal substances with a 0.9% sodium chloride solution should be determined by the doctor by checking for a possible change in color and / or the appearance of a precipitate of insoluble complexes or crystals. Before adding, it is necessary to determine whether the substance to be added is soluble and stable in water at a pH level similar to that of a 0.9% sodium chloride solution. When adding a drug, it is necessary to determine the isotonicity of the resulting solution before administration. Before adding drugs to the solution, they must be thoroughly mixed in compliance with the rules of asepsis. The prepared solution should be administered immediately after preparation, do not store! Each unused dose should be discarded. Interaction with other drugs Isotonic sodium chloride solution can be mixed with other hydrophilic drugs. The simultaneous use of corticosteroids or corticotropin increases the risk of developing hypernatremia, hypervolemia and peripheral edema. When using a solution of sodium chloride 9 mg / ml as a solvent and diluent, it must be used in accordance with the instructions for medical use of the main drug. When mixing with other drugs, compatibility must be checked visually (see section “Precautions”). Contraindications 0.9% sodium chloride solution is contraindicated in case of circulatory disorders threatening cerebral and pulmonary edema, acidosis, hyperchloremia, hypokalemia, hypoglycemia, hypernatremia, extracellular hyperhydration, severe heart failure with severe symptoms of congestion in the small circle, anasarca and other manifestations of extracellular hyperhydration. 0.9% sodium chloride solution is also contraindicated in cerebral and pulmonary edema, acute LV insufficiency, concomitant administration of corticosteroids in large doses. Caution should be given to large volumes of isotonic sodium chloride solution in patients with renal insufficiency. Active ingredient: sodium chloride – 1800.0 mg; excipients: hydrochloric acid 1 M solution – up to pH 5.0-7.5, water for injection – up to 200 ml. Theoretical osmolality is 310 mOsm/kg. Overdose Introduction of large volumes of isotonic sodium chloride solution can lead to edema, hypernatremia, hyperchloremia, hypokalemia and hypocalcemia; hypervolemia, hypertension, hyperhydration, cerebral and pulmonary edema. Side effects When used correctly, undesirable effects are unlikely. Adverse reactions recorded during post-marketing use are grouped by systems and organs in accordance with the MedDRA dictionary and are listed below in descending order of their severity without indicating the frequency of occurrence. From the circulatory system: acidosis, hyperhydration, hypokalemia. From the immune system: hypersensitivity reactions or infusion reactions, including hypotension, pyrexia, tremor, chills, urticaria, rash, itching. General disorders and disorders at the injection site: reactions at the injection site, such as erythema, hemorrhage / hematoma, burning sensation, urticaria at the injection site, thrombosis or phlebitis at the injection site. Others: fever, infections at the injection site (in violation of the rules of antiseptics). When using the drug as a base solution (solvent) for other drugs, the likelihood of side effects is determined by the properties of these drugs. In this case, if adverse reactions occur, the administration of the solution should be suspended, the patient’s condition should be assessed, adequate measures taken, and the remaining solution should be saved for analysis, if necessary. In the event of the above adverse reactions or adverse reactions not listed in these instructions for medical use of the drug, you should consult a doctor. Storage conditionsStore at a temperature not exceeding 25 °C. Keep out of the reach of children. Buy Sodium chloride solution for injection isotonic 9mg/ml in ampoules 5ml №10 Price for Sodium chloride solution for injection isotonic 9mg/ml in ampoules 5ml №10