Ospamox DT dispersible tablets 500mg №12×1

Name Ospamox DT tabl. disp. 500mg in bl. in pack. №12×1 Pharmacological actionView this section of the drug description is available only to registered users of the site PharmacokineticsView this section of the drug description is available only to registered users of the site otitis, acute sinusitis and tonsillitis caused by group A beta-hemolytic streptococcus; infections of the lower respiratory tract: exacerbation of chronic bronchitis, community-acquired pneumonia; infections of the lower urinary tract: cystitis; early treatment of Lyme disease accompanied by isolated erythema migrans (stage 1); eradication of Helicobacter pylori (as part of combination therapy). Prevention of an increased risk of endocarditis, i.e. operations in the oral cavity and upper respiratory tract. Dosing regimen The dose of amoxicillin depends on the age, body weight and kidney function of the patient, as well as on the severity and localization of the infection and on the causative agent of the disease. The drug is taken orally, regardless of the meal. The tablet can be dissolved in water, mixed and swallowed, or taken with water. Tablets can be broken apart for easier swallowing. Treatment of infectious and inflammatory diseases In general, treatment should continue for another 2-3 days after the disappearance of symptoms. In infections caused by beta-hemolytic streptococcus, the duration of treatment to destroy the pathogen should be at least 10 days. Parenteral treatment is indicated if oral administration is considered impossible or inappropriate, and especially for emergency treatment of severe infection. For adults and children over 12 years of age with exacerbation of chronic bronchitis, the drug is prescribed 1 g 2 times / day. For elderly patients without impaired renal function, the dose is the same as for adults. In case of impaired renal function, a correction of the dosing regimen is required (table 1). In patients with CC less than 30 ml / min, it is recommended to increase the interval between doses or reduce subsequent doses. In renal failure, a short course of treatment with a single dose of 3 g cannot be prescribed. Adults, including elderly patients: CC, ml / min Dose Interval between doses > 30 No correction required 10-30 500 mg 12 h <10 500 mg 24 h During hemodialysis, the drug is prescribed at a dose of 500 mg at the end of the procedure. Prevention of endocarditis For the prevention of endocarditis in patients not receiving general anesthesia, the drug is prescribed at a dose of 2-3 g 1 hour before surgery, followed (after 6 hours) by an additional dose of 3 g, if necessary. A dose of 50 mg amoxicillin/kg body weight is recommended for children. Local official guidelines for the prevention of endocarditis should be taken into account to clarify the details and describe the risk to patients. Side effects Determination of the frequency of adverse reactions: often (> 1/100, < 1/10), infrequently (> 1/1000, < 1/100), rarely (> 1/10,000, <1/1000), very rarely, including individual messages (< 1/10,000). On the part of the digestive system: often - gastric disorders, nausea, loss of appetite, vomiting, flatulence, loose stools, diarrhea, enanthemas (especially in the oral cavity), dry mouth, impaired taste sensations (these effects are mostly weak and often disappear or during treatment, or immediately after its completion; the occurrence of these side effects can be reduced by taking amoxicillin with meals); rarely - superficial discoloration of the teeth (usually disappears after brushing the teeth); very rarely - severe and persistent diarrhea (one should keep in mind the very rare possibility of pseudomembranous colitis; prescribing drugs that depress peristalsis is contraindicated), black color of the tongue. Hepatobiliary disorders: infrequently - a moderate and transient increase in liver enzymes; rare - hepatitis and cholestatic jaundice. On the part of the skin: often - exanthema, itching, urticaria; typical morbiliform exanthema occurs 5-11 days after the start of therapy. Allergic reactions: often - the immediate appearance of urticaria (indicates an allergic reaction to amoxicillin, so treatment should be stopped); rarely - laryngeal edema, allergic vasculitis, anaphylactic shock, angioedema (Quincke's edema), erythema multiforme exudative, acute generalized pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis and bullous and exfoliative dermatitis. From the hemopoietic system: rarely - eosinophilia and hemolytic anemia; very rarely - leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia, myelosuppression, agranulocytosis, increased bleeding time and prothrombin time. All were reversible upon discontinuation of treatment. From the nervous system: rarely - hyperkinesis, dizziness and convulsions. Convulsions are possible in patients with impaired renal function or when using the drug in high doses. From the urinary system: rarely - acute interstitial nephritis. Infections and invasions: infrequently - superinfections and colonization by resistant microorganisms or yeast fungi in the form of oral or vaginal candidiasis after prolonged and repeated use of amoxicillin. Other: rarely - blood disease, drug fever. Contraindications for use hypersensitivity to the components of the drug; hypersensitivity to penicillins; cross-allergy to beta-lactam antibiotics such as cephalosporins, carbapenems should be taken into account. The drug should be used with caution if the patient currently has or has a history of kidney disease (dose adjustment may be required), infectious mononucleosis or leukemia (increased risk of skin reactions), severe allergies or bronchial asthma (possible increased risk of allergic reactions); in patients with a catheter in the bladder (drink more fluids to prevent the formation of crystals in the urine); with severe vomiting or diarrhea (impaired absorption of the drug); with diabetes mellitus (against the background of drug treatment, a violation of the result of a urine test for glucose is possible). Use during pregnancy and lactation Caution should be exercised when prescribing the drug to pregnant women. Amoxicillin crosses the placental barrier and fetal plasma concentrations are approximately 25-30% of maternal plasma concentrations. Data from a limited number of pregnant women did not show an adverse effect of amoxicillin on pregnancy or on the health of the fetus / newborn child. Currently, there are no significant epidemiological data. Amoxicillin may reduce the amount of estriol in the urine of pregnant women. Amoxicillin is excreted in breast milk (approximately 10% of the corresponding plasma concentration) and in rare cases this leads to diarrhea and / or fungal colonization of the mucous membrane in the infant. It should also take into account the possible sensitization of the infant to beta-lactam drugs. In experimental animal studies, no direct or indirect harmful effects on pregnancy, embryonic/fetal development, childbirth or postnatal development have been identified. Special instructions Forced diuresis leads to a decrease in the concentration of amoxicillin in the blood by increasing its elimination. The occurrence of diarrhea can interfere with the absorption of the drug and therefore reduce its effectiveness. High concentrations of amoxicillin in the urine can cause false positive reactions when testing urine for glucose using Benedict's reagent or Fehling's solution. In these cases, to determine the level of glucose, it is recommended to use methods based on enzymatic reactions of glucose oxidation. The results of the Coombs test can also be false positive. At high concentrations, amoxicillin can reduce glycemia. When using colorimetric methods, amoxicillin may interfere with the determination of proteins. OverdoseSymptoms: Acute toxic effects, even if accidentally taken in high doses. Both gastrointestinal disorders and disturbance of water and electrolyte balance are possible. In patients with severe kidney damage, significant overdose may result in signs of renal toxicity; possible appearance of crystalluria. Treatment: the appointment of activated charcoal (gastric lavage is usually not required), symptomatic therapy. Particular attention should be paid to the water and electrolyte balance of the body. There is no specific antidote for amoxicillin. Amoxicillin can be removed by hemodialysis. Drug interactions Simultaneous administration is not recommended Simultaneous administration with allopurinol may contribute to the appearance of allergic skin reactions. With simultaneous appointment with amoxicillin, an increase in the absorption of digoxin is possible (digoxin dose adjustment may be required). The simultaneous appointment of disulfiram is contraindicated. The simultaneous appointment of amoxicillin and anticoagulants from the coumarin group may increase bleeding time (dosage adjustment of anticoagulants may be required). By inhibiting the excretion of amoxicillin by the kidneys, the simultaneous administration of probenecid leads to an increase in the concentration of amoxicillin in the blood and bile. Amoxicillin should not be combined with bacteriostatic drugs / antibiotics (such as tetracyclines, macrolides, sulfonamides or chloramphenicol), because. observed antagonism in vitro. With simultaneous administration with aminoglycosides, synergism may be noted. The toxicity of methotrexate, which occurs when administered with amoxicillin, is described. When taking amoxicillin and methotrexate at the same time, the concentration of methotrexate in the blood plasma should be carefully monitored. Amoxicillin reduces the renal clearance of methotrexate, probably due to competition with the transporters of the tubular secretory system. With simultaneous use, caution is required. Amoxicillin is able to transiently reduce plasma concentrations of estrogen and progesterone, which leads to a decrease in the effectiveness of oral contraceptives. Therefore, the use of additional non-hormonal contraceptive measures is recommended. Terms of dispensing from pharmacies The drug is dispensed by prescription. Storage conditions of the drug The drug should be stored out of the reach of children, protected from moisture at a temperature not exceeding 30°C. Shelf life of the drug Shelf life - 3 years. Buy Ospamox DT dispersible tablets 500mg No. 12x1