Name:
ORVIcold por.d/prig.p-ra d/pr.in. (orange) in pack. 10g in pack No. 10
Description:
Powder of white or almost white color with the smell of orange. Soft lumps are allowed. ORVIcold (orange). The main active ingredient Paracetamol + phenylephrine + pheniramine Release form Powder for solution for oral administration (orange). Dosage 10 g Special instructions In order to avoid toxic damage to the liver, the drug should not be combined with the use of alcoholic beverages. Caution should be exercised when using the drug in people over the age of 70 with cardiovascular disease due to the possible manifestation of the vasoconstrictor effect of phenylephrine. If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature, you should consult a doctor. Do not exceed recommended doses. Do not use the drug from damaged bags. Pharmacodynamics Combined drug, has antipyretic, anti-inflammatory, anti-edematous, analgesic and anti-allergic effects. Paracetamol has antipyretic, analgesic and some anti-inflammatory effects, reduces pain associated with colds, sore throat, headache, muscle and joint pain, and reduces high temperature. It blocks cyclooxygenase of the first and second types mainly in the central nervous system. Due to the absence of a blocking effect on the synthesis of prostaglandins in peripheral tissues, it does not affect the water-salt metabolism (retention of Na + and water) and the mucous membrane of the gastrointestinal tract. Phenylephrine hydrochloride has a sympathomimetic effect: reduces hyperemia and swelling, causes vasoconstriction of the nasal mucosa and paranasal sinuses. Pheniramine maleate is a blocker of H1 – receptors, has an anti-allergic effect: it reduces the severity of exudative local manifestations of infection, stops lacrimation, reduces itching in the eyes and nose, and eliminates rhinorrhea. Indications for use Short-term symptomatic treatment of influenza and colds, including fever and chills, headache, runny nose, nasal congestion, sneezing and body aches. Dosage and administration Dissolve the contents of 1 sachet in a glass of boiled hot water and drink hot. Adults and children over 12 years old: 1 sachet every 4-6 hours (as needed to relieve symptoms), not to exceed 3 sachets per day. A single dose should not exceed 1 packet. It is not recommended to use the drug for longer than 7 days. Use during pregnancy and lactation The drug is contraindicated during pregnancy or lactation. Children The drug is not used in children under 12 years of age. The ability to influence the reaction rate when driving vehicles or other mechanisms During treatment, it is not recommended to drive vehicles and work with complex mechanisms that require increased concentration and high speed of psychomotor reactions. With the simultaneous use of sedatives, tranquilizers or alcohol, drowsiness may increase. Appropriate safety precautions for use Do not exceed the recommended dose or take the drug for more than 7 days in a row. A doctor should be consulted if symptoms: do not improve within 7 days are accompanied by a fever that persists for more than 3 days include a sore throat that does not go away for more than 3 days is accompanied by fever, headache, rash, nausea or vomiting. Should be avoided simultaneous use of other medicines containing paracetamol. When using the drug, it is not recommended to drink alcoholic beverages, since ethyl alcohol while taking paracetamol can cause liver dysfunction. The drug is used with caution in patients with prostatic hypertrophy, thyroid, liver and kidney diseases, bradycardia, acute pancreatitis, patients over 70 years of age with cardiovascular diseases. It should not be used in patients who are being treated with other medicines without a doctor’s prescription. Phenylephrine may contribute to false positive doping control results in athletes. Interactions with other drugs Drug interactions with paracetamol are usually minor, but increase when concomitant drugs are such as anticoagulants (warfarin and coumarin) and anticonvulsant drugs with a low therapeutic index. Simultaneous use of paracetamol with NSAIDs may increase their nephrotoxicity. Pharmacodynamic interactions may occur with other pain relievers such as caffeine, opiates; barbiturates reduce the antipyretic effect. The half-life of chloramphenicol is increased. Probenecid, cholestyramine inhibit the metabolism of paracetamol. Treatment of tuberculosis with rifampicin and isoniazid increases the hepatoxicity of paracetamol. Antiepileptic drugs (phenobarbital, phenytoin, carbazepine) do not increase the risk of hepatotoxicity. Phenylephrine hydrochloride should not be used with MAO inhibitors, alpha- and beta-adrenergic blockers, antihypertensive agents, phenothiazine derivatives (eg promethazine), bronchodilator sympathomimetic agents, tricyclic antidepressants, guanethidine or atropine, digitalis alkaloids, rauwolfia alkaloids, indomethacin, glucocorticoids, methyldopa ; drugs that affect appetite, amphetamine-like psychostimulants, labor stimulants, anesthetics, ergot alkaloids. Pheniramine maleate potentiates the action of drugs that depress the central nervous system (for example, antiparkinsonian and antipsychotic drugs), as well as alcohol, inhibits the action of anticoagulants and interacts with progesterone, reserpine, thiazide diuretics. Oral contraceptives may reduce the effectiveness of antihistamines. Contraindications Hypersensitivity to the components of the drug. Severe cardiovascular, hepatic or renal insufficiency, congenital hyperbilirubinemia, arterial hypertension; pheochromocytoma, thyrotoxicosis, prostate adenoma with difficulty urinating, bladder neck obstruction, blood diseases, pyloroduodenal obstruction, stenotic gastric and duodenal ulcer, diabetes mellitus, lung diseases (including bronchial asthma), glaucoma, glucose-6-phosphate dehydrogenase deficiency, epilepsy, alcoholism, concomitant treatment with MAO inhibitors and within 2 weeks after stopping their use. Composition One sachet contains: Active substances: paracetamol 325 mg, pheniramine maleate 20 mg, phenylephrine hydrochloride 10 mg. Excipients: anhydrous citric acid, sugar, flavor (orange) (powder for oral solution (orange). Overdose Symptoms caused by paracetamol: hepatotoxic effect, in severe cases, liver necrosis develops, accompanied by nausea, vomiting, abdominal pain, which may appear within 24-48 hours after an overdose.Violation of glucose metabolism and metabolic acidosis, acute renal failure with tubular necrosis; arrhythmia, pancreatitis, sulfhemoglobinemia, methemoglobinemia, anemia; Symptoms caused by potentiation of the parasympathetic action of the antihistamine component and the sympathomimetic action of phenylephrine hydrochloride: hemodynamic changes and cardiovascular insufficiency with respiratory depression, drowsiness, which may cause agitation (especially in children); depression, ulcers of the oral mucosa, blurred vision, headache, dizziness, insomnia, coma, convulsions, behavioral changes nia, arterial hypertension, bradycardia, atropine-like “psychosis”. Treatment: gastric lavage, intravenous or oral administration of N-acetylcysteine as an antidote to paracetamol, administration of activated charcoal, saline laxative, monitoring of respiration and circulation (adrenaline should not be used). Symptomatic treatment and supportive therapy. In case of convulsions, diazepam is prescribed. With arterial hypotension, alpha-adrenergic blockers or vasoconstrictors can be used. Side effects The most common side effects are: dizziness, dry mouth or throat, fatigue, headache, anxiety, nervousness, tachycardia, palpitations, agitation, sleep disturbance, edema are rarely noted. Rarely can be observed: allergic reactions: itching, rash, urticaria, in isolated cases – erythematous and other skin reactions, petechiae, angioedema, bronchospasm, drop in blood pressure even to shock, anaphylaxis; from the digestive tract: digestive disorders, including constipation , nausea, vomiting, diarrhea or flatulence, epigastric pain, impaired liver function; from the endocrine system: fluctuations in blood sugar levels; from the nervous system: confusion, vestibular disorders. Adverse reactions caused by paracetamol: thrombocytopenia, leukopenia, hemolytic anemia, in isolated cases – agranulocytosis. Patients with intolerance to acetylsalicylic acid (5 – 10%) also react to paracetamol (for example, asthmatics); caused by phenylephrine: increased blood pressure, heart pain, mydriasis, impaired vision and accommodation, increased intraocular pressure and potential effects on endocrine and other metabolic regulators, impaired urination; caused by pheniramine: dry eyes, insomnia, in some cases – coma, convulsions, dyskinesia, behavioral changes. Unlike second-generation antihistamines, pheniramine is not associated with QTc prolongation and arrhythmia. Storage conditions In a place protected from moisture and light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Buy Orvicold powder for oral solution (orange) in bags 10g No. 10 Price for Orvicold powder for oral solution (orange) in bags 10g No. 10 for oral administration (orange) in packages 10g №10
Orvicold powder for solution for oral administration (orange) in bags 10g №10
$18.00
SKU: 68325
Category: Medicines for colds and flu
INN | OTHER |
---|---|
The code | 68 325 |
Barcode | 4 812 608 003 149 |
Dosage | 10g |
Active substance | Paracetamol, phenylephrine hydrochloride, pheniramine maleate |
Manufacturer | Lekpharm SOOO, Belarus |
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