Nimesubel gel 18g №1

Name:
Nimesubel gel d / nar.prim.10mg / g in tubes 18g in pack No. 1
Description:
Transparent gel of light yellow or yellow color. The main active ingredient Nimesulide Release form Gel Dosage 10 mg / g Pharmacological action Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) from the class of sulfonamides. It has an analgesic and anti-inflammatory effect. The effect of nimesulide is due to selective blockade of cyclooxygenase-2, as well as a number of other mechanisms: suppression of the synthesis of platelet activating factor; a decrease in the production of superoxide anion by stimulated polymorphonuclear leukocytes through the suppression of protein kinase C and type IV phosphodiesterase; preventing bradykinin and cytokine-induced hyperalgesia by inhibiting the release of tumor necrosis factor a; neutralization of hypochloric acid; prevention of inactivation of β-proteinase inhibitors; inhibition of proteases (including elastase, collagenase); inhibition of histamine release from basophils and mast cells; slowing down the degradation of the cartilage matrix through inhibition of the synthesis of metalloproteases. When applied topically, nimesulide causes pain relief at the site of application of the gel, including joint pain at rest and during movement. Indications for use Acute painful manifestations that occur with uncomplicated injuries, including sports ones; with sprains or ruptures of ligaments and tendons of muscles; tendinitis; bruises of muscles and ligaments. Dosage and administration For external use only. Wash and dry skin thoroughly before application. Apply a gel column about 3 cm long in a uniform thin layer to the area of maximum pain and the surrounding area, rubbing in with light movements, 3-4 times a day or as directed by a doctor. Do not use under airtight dressings. The amount of gel and the frequency of its application (no more than 4 times a day) may vary depending on the size of the treated area and the patient’s response. Usually the course of treatment lasts 7-15 days. If necessary, repeated courses of treatment are recommended after 3-5 days. Wash your hands with soap and water before and after the procedure. Application during pregnancy and lactation Nimesulide is not used during pregnancy and lactation. Studies confirming its effectiveness and safety of use during pregnancy and lactation have not been conducted. There are no data on the effect on fetal development. Precautions It is not recommended to apply the drug to damaged and infected areas of the skin, and avoid contact with areas affected by skin diseases and open wounds. It is necessary to avoid getting the gel in the eyes and on other mucous membranes. Do not use under airtight dressings. Wash your hands with soap and water after applying the gel. Do not touch sensitive areas of the skin during the procedure and before cleansing the hands from the remnants of the drug. Close the tube tightly after using the gel. The drug should be used with caution in patients with an increased risk of side effects associated with taking salicylates. If local irritative reactions occur, the use of the drug should be suspended and a doctor should be consulted. The degree of manifestation of side effects can be reduced by using the minimum effective dose for a short period of time. The drug should be used with caution in erosive and ulcerative lesions of the gastrointestinal tract, in patients with renal (creatinine clearance less than 30 ml / min) or severe liver failure, severe bleeding disorders, congestive heart failure / uncontrolled. Since the use of other NSAIDs may cause burning and, in rare cases, photodermatitis, caution should be exercised when using nimesulide gel. To reduce the risk of photosensitivity, avoid exposure to direct sunlight or tanning lamps. If symptoms persist or worsen, seek medical attention. Use in children Indications and recommendations for use in children are not known. Nimesulide is contraindicated in children under 12 years of age. Interaction with other drugs Topical application of nimesulide does not have a clinically significant effect on the metabolism of other drugs. Contraindications Hypersensitivity to nimesulide or any other component of the drug; “aspirin” asthma; dermatoses, epidermal lesions, skin infections in the area of application. Pregnancy and lactation; children’s age up to 12 years. The drug should be used with caution in erosive and ulcerative lesions of the gastrointestinal tract, in patients with renal (creatinine clearance less than 30 ml / min) or severe liver failure, severe bleeding disorders, congestive heart failure / uncontrolled. Composition Each tube contains: active ingredient: nimesulide -180 mg; excipients: carbomer interpolymer type A, N-methylpyrrolidone, propylene glycol (E1520), macrogol 400 (E1521), isopropyl alcohol, sodium benzoate (E211), potassium dihydrogen phosphate (E340), purified water. Overdose Cases of overdose with topical application of the drug are not described. However, when applying large amounts of gel (exceeding 50 g) to large areas of the skin, the development of an overdose (systemic reactions) is not excluded. There is no specific antidote. You need to see a doctor. Side effects Locally applied preparations of nimesulide are usually well tolerated. Local adverse reactions may occur: hyperemia, rash, itching, urticaria, peeling, transient discoloration of the skin (does not require discontinuation of the drug). If any adverse reactions occur, stop using the drug and consult a doctor. Storage conditionsStore at a temperature not exceeding 25°C. Do not freeze. Keep out of the reach of children. Buy Nimesubel gel 18g №1 Price for Nimesubel gel 18g №1Instruction for use for Nimesubel gel 18g №1