Methionine tablets p/o 250mg №10×5

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Methionine tablets 250 mg in a blister pack No. 10×5
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Round-shaped tablets with a biconvex surface, film-coated, pink. Inclusions are allowed on the surface of the tablets. Main active ingredient D,L-methionine Dosage 250 mg Composition 1 tablet contains D, L-methionine 250 mg; excipients: potato starch, anhydrous colloidal silicon dioxide, calcium stearate, polysorbate; shell: sugar, light magnesium carbonate, povidone, anhydrous colloidal silicon dioxide, talc, titanium dioxide (E 171), Ponceau 4R dye (E 124), yellow wax, light mineral oil. Pharmacological propertiesMethionine is an essential amino acid that is involved in the processes of remethylation. Chemically, methionine is converted to cysteine, a precursor of glutathione, which is involved in detoxification reactions. It has a lipotropic effect, promotes the synthesis of choline, phospholipids; participates in the synthesis of adrenaline, creatine; activates the action of hormones, vitamins, enzymes. It has detoxifying properties due to the ability to methylate toxic products. Reduces the concentration of cholesterol in the blood and increases the content of phospholipids. Easily absorbed from the intestines. As an essential sulfur-containing amino acid, it is used for protein synthesis and enters into various metabolic reactions – remethylation, deamination, decarboxylation. With urine it is allocated in a small amount. Indications Treatment (as part of complex therapy) of diseases and toxic liver damage: toxic hepatitis, alcoholic hepatopathy, cirrhosis of the liver, poisoning with paracetamol and other hepatotoxic drugs. Contraindications The drug should not be used: with hypersensitivity to the active substance or any other component of the drug; with homocystinuria; with urate and cystine stones; with renal failure; with oxalosis; with a deficiency of methionine adenosyltransferase; with metabolic (for example, renal tubular) acidosis; infants. Due to the risk of synthesis of neurotoxic mercaptans during bacterial metabolism, methionine should not be used in patients with hepatic insufficiency or hepatic encephalopathy. Precautions when using Before using the drug, consult your doctor! Do not use the drug for longer than the indicated time without consulting a doctor! With a lack of folic acid, vitamins B2, B6 and/or B12, treatment with methionine may lead to an increase in homocysteine levels. Hyperhomocysteinemia can be considered as an independent risk factor for atherosclerosis. With prolonged use of the drug, it is necessary to follow a diet containing a sufficient amount of folic acid and B vitamins. If necessary, their deficiency should be replenished. In hyperthyroidism, the metabolism of homocysteine in blood plasma can be accelerated, therefore, before starting treatment with methionine, it is necessary to check the function of the thyroid gland. Taking methionine can lead to increased excretion of calcium in the urine (hypercalciuria). In the case of long-term treatment with methionine, regular monitoring of mineral metabolism is necessary. In patients at risk of developing acidosis, long-term treatment with methionine should be carried out under the control of acid-base balance in the blood. Interaction with other drugs If you are taking any other drugs, be sure to consult your doctor about the possibility of taking the drug! The action of some substances (eg, ampicillin, carbenicillin, sulfonamides, nitrofurantoin, nalidixic acid) may be enhanced by prolonging the plasma half-life. The co-administration of levodopa and methionine may lead to a decrease in the effectiveness of levodopa in patients with Parkinson’s disease, therefore, an increase in the dose of methionine in such patients should be avoided. Special instructions for children. The drug should not be used in children under 12 years of age, as there are no data on proper studies in this category of patients. Use during pregnancy and lactation There are no sufficient data on the use of methionine during pregnancy and lactation. Animal studies do not indicate direct or indirect harmful effects of methionine on pregnancy or embryonic development. During pregnancy or lactation, the use of the drug is possible if the benefit to the mother outweighs the potential risk to the fetus / child. Ability to influence the reaction rate when driving vehicles or operating other mechanisms No data available. Dosage and administration Adults are prescribed 500-1500 mg 3-4 times a day. Children single doses: 3-6 years – 250 mg, 7 years and older – 500 mg. Multiplicity of reception – 3-4 times a day. The drug should be taken 30 minutes – 1 hour before meals. The course of treatment is 10-30 days or 10 days each with 10-day breaks between these courses. In case of paracetamol poisoning, the following dosage is recommended: 2500 mg every 4 hours until a dosage of 10,000 mg is reached. Overdose Cases of acute intoxication are not described. With prolonged overdose (about 15 g / day), atrophy of secreting organs, such as the parotid, submandibular and sublingual glands, is possible. Side effects Changes in blood pH to the acid side in patients at risk of developing acidosis. Perhaps the appearance of nausea, vomiting, diarrhea, drowsiness, irritability. If you experience unwanted effects, consult your doctor regarding the further use of the drug. The drug should not be used after the expiration date. Storage conditions Store in the original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children! Buy Methionine tablets p/o 250mg №10×5 Price for Methionine tablets p/o 250mg №10×5