Name:
Magne B6 tablets No. 60
Description:
Oval biconvex tablets, white coated, with a smooth shiny surface. Release form: 10 tablets in a PVC/aluminum foil blister. 5 blisters, together with instructions for use, are placed in a cardboard box. Special instructions Information for patients with diabetes mellitus: coated tablets contain sucrose as an excipient. In the case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations. In the case of concomitant calcium deficiency, it is recommended to eliminate the magnesium deficiency before taking calcium supplements or calcium supplements. With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body. The drug in the form of tablets is intended only for adults and children over 6 years of age. For young children (over 1 year), the drug is recommended in the form of an oral solution. Pharmacological action Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and in muscle contraction. The body receives magnesium from food. The lack of magnesium in the body can be observed in violation of the diet (diet) or with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, use of diuretics). Pyridoxine (vitamin B6) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Pharmacokinetics Absorption of magnesium in the gastrointestinal tract is no more than 50% of the dose taken orally. 99% of the magnesium in the body is found inside the cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and 1/3 is in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the received dose of magnesium is excreted in the urine. Indications for use Magnesium absorption in the gastrointestinal tract is no more than 50% of the dose taken orally. 99% of the magnesium in the body is found inside the cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and 1/3 is in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the received dose of magnesium is excreted in the urine. Dosage and administration: Adults are advised to take 6-8 tablets per day. Children over 6 years old (weighing more than 20 kg) 4-6 tablets per day. Use during pregnancy and lactation Clinical experience with the use of the drug in a sufficient number of pregnant women did not reveal any adverse effect on the occurrence of fetal malformations or fetotoxic effects. The drug Magne B6 can be used during pregnancy only if necessary, on the advice of a doctor. Magnesium passes into breast milk. The use of the drug during lactation and breastfeeding should be avoided. Precautions With caution: moderate degree of renal failure (danger of developing hypermagnesemia). Interaction with other drugs Contraindicated combinations – With levodopa: the activity of levodopa is inhibited by pyridoxine (if this drug is not combined with inhibitors of peripheral decarboxylase of aromatic L-amino acids). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with inhibitors of peripheral aromatic L-amino acid decarboxylase. Not recommended combinations – The simultaneous use of drugs containing phosphates or calcium salts may impair the absorption of magnesium in the intestine. Combinations to be taken into account – When prescribing tetracyclines by mouth, an interval of at least three hours between the intake of tetracycline and Magne B6 should be observed, since magnesium preparations reduce the absorption of tetracyclines. Contraindications Hypersensitivity to the components of the drug. Severe renal failure (Cl creatinine <30 ml / min). Children's age up to 1 year. Simultaneous reception of levodopa (see "Interaction"). Composition Core of the tablet: active ingredients: magnesium lactate dihydrate* - 470 mg; pyridoxine hydrochloride - 5 mg; excipients: sucrose - 115.6 mg, heavy kaolin - 40.0 mg, acacia gum - 20.0 mg, carboxypolymethylene 934 - 10.0 mg, talc (magnesium hydrosilicate) - 42.7 mg, magnesium stearate - 6, 7 mg. Tablet shell: acacia gum - 3.615 mg, sucrose - 214.969 mg, titanium dioxide - 1.416 mg, talc (magnesium hydrosilicate) - traces, carnauba wax (powder) - traces. * - equivalent to the content of magnesium (Mg++) 48 mg. Overdose With normal kidney function, an overdose of magnesium when taken orally does not usually lead to toxic reactions. However, in case of renal insufficiency, magnesium poisoning may develop. Overdose symptoms, the severity of which depends on the concentration of magnesium in the blood: lowering blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome. Treatment Rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis. Side effect Immune system disorders Very rare (<0.01%): allergic reactions, including skin reactions. Gastrointestinal disorders Not known (frequency cannot be estimated from the available data): diarrhea, abdominal pain, nausea, vomiting, flatulence. Storage conditions In a place protected from light, at a temperature not exceeding 25 ° C. Buy Magne B6 tablets p/o 48mg/5mg No. 20x3 (magnesium lactate dihydrate + magnesium pidolate + pyridoxine hydrochloride) for Magne B6 tablets p / o 48mg / 5mg No. 20x3 (magnesium lactate dihydrate + magnesium pidolate + pyridoxine hydrochloride)
Magne B6 tablets p/o 48mg/5mg №20×3 (magnesium lactate dihydrate + magnesium pidolate + pyridoxine hydrochloride)
$39.00
INN | PYRIDOXINE G / CL + MAGNESIUM LACTATE |
---|---|
The code | 133 636 |
Barcode | 3 664 798 032 550 |
Active substance | Magnesium lactate, pyridoxine g/chl |
Manufacturer | HINOIN Plant of Pharmaceutical and Chemical Products CJSC, Hungary |
Importer | Republican Unitary Enterprise "Belpharmacy" Minsk, 220005, Republic of Belarus, Minsk, st. V. Khoruzhey, 11; LLC "Iskamed", Republic of Belarus, 220036, Minsk, K. Liebknekhta st., 70, office 6; PTCHUP "Novamedica" Minsk, 223017 Minsk district, Gatovo village, Metallurgical street, 16a-3; Komfarm LLC, Minsk, 220131 Minsk, Sosnovy Bor st., 4, room 1; "VitPharmMarket" LLC Vitebsk, Republic of Belarus, 210004 Vitebsk, 5th Kooperativnaya st., 8; IOOO "Interfarmaks", Republic of Belarus, 223028, Minsk region, Minsk district, Zhdanovichsky s / s, ag. Zhdanovichi, st. Zvezdnaya, 19A-5, pom. 5-2 |
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