NameDekamevit tabl p/o in blister. in unitary enterprise No. 10×2 Basic physical and chemical properties of round-shaped tablets with a biconvex surface, film-coated yellow. They have a characteristic smell. Active ingredients: 1 tablet contains vitamin A 6,600 IU, vitamin E (?-tocopherol acetate) or dry vitamin E 50% 10 mg, vitamin B1 (thiamine hydrochloride) 20 mg, vitamin B2 (riboflavin) 10 mg, vitamin B6 (pyridoxine hydrochloride) 20 mg, vitamin C (ascorbic acid) 200 mg, folic acid (vitamin Bc) 2 mg, nicotinamide (vitamin PP) 50 mg, rutin (vitamin P) 20 mg, methionine 200 mg, vitamin B12 (cyanocobalamin) 0, 1 mg; excipients: croscarmellose sodium, mannitol (E 421), magnesium stearate; sheath: mixture for film coating Opadry AMB II White: partially hydrolyzed polyvinyl alcohol, talc, titanium dioxide (E 171), glycerol monocaprylocaprate. sodium lauryl sulfate; film coating mixture Opadry II Yellow (polydextrose, talc, quinoline yellow aluminum lacquer (E 104), hypromellose, maltodextrin, medium chain triglycerides, titanium dioxide (E 171)). Pharmacotherapeutic group Multivitamins in combination with other agents. Pharmacological properties Pharmacodynamics. A multivitamin drug, the properties of which are due to the vitamins that make up its composition and take an active part in almost all biochemical reactions of the body. A rationally selected composition contributes to the manifestation of a more pronounced and versatile biological effect of the drug. Vitamin A (retinol acetate) is necessary for the development of epithelial cells and the synthesis of visual pigment. Vitamin E (?-tocopherol acetate) is a fat-soluble vitamin with a pronounced antioxidant and radioprotective effect, takes part in the biosynthesis of heme and proteins, cell proliferation and other most important processes of cell metabolism, improves oxygen consumption by tissues, and also has an angioprotective effect, affecting vascular tone and permeability, stimulating the formation of new capillaries. Vitamin B1 (thiamine hydrochloride) normalizes the functional activity of the nervous, cardiovascular and digestive systems. Vitamin B2 (riboflavin) plays an important role in protein, fat and carbohydrate metabolism, takes part in maintaining normal visual acuity, and normalizes skin functions. Vitamin B6 (pyridoxine hydrochloride) is necessary for the regeneration of the skin and liver cells, the restoration of the nervous system, and improves fat metabolism in atherosclerosis. Vitamin C (ascorbic acid) plays an important role in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, normal capillary permeability, the formation of steroid hormones and connective tissue components, and helps to increase the body’s resistance to infectious diseases. Vitamin Bc (folic acid), in addition to the antianemic effect during pregnancy, protects the fetus from the influence of teratogenic factors, takes part in the metabolism and synthesis of amino and nucleic acids. Vitamin PP (nicotinamide) is a specific anti-pellagic agent that improves carbohydrate metabolism. Vitamin P (rutin) – P-vitamin-like water-soluble substance, flavonoid. Rutin interacts with ascorbic acid, takes part in the regulation of the formation of connective tissue collagen, prevents the depolymerization of hyaluronic acid by hyaluronidase, and activates tissue respiration. The essential amino acid methionine plays a role in the synthesis of a number of biologically important compounds, activates the effects of hormones, vitamins and enzymes, neutralizes toxic products. Vitamin B12 (cyanocobalamin) affects the processes of normal maturation of all body cells, especially blood and liver cells, positively affects the functioning of the nervous system and liver. Pharmacokinetics. Fat-soluble vitamins that are part of the drug (vitamin A, vitamin E) are able to be deposited in tissues. Water-soluble vitamins (vitamins B1, B2, B6, B12, C, PP) are converted into coenzymes and, when combined with an apoenzyme, are part of complex enzymes. Since the lifespan of enzymes is limited, the coenzymes break down and are excreted from the body in the form of various metabolites. Fat-soluble vitamins are also catabolic and excreted from the body, although more slowly than water-soluble vitamins. Indications As a remedy for hypovitaminosis and avitaminosis of vitamins A, E, C, B1, B2, B3, B6, B9, B12, arising, for example, in such conditions: inadequate and / or unbalanced nutrition (diet, malabsorption of various origins, chronic alcoholism) ; recovery period after long, severe illnesses; debilitating physical and mental stress; prolonged antibiotic therapy. E, thyrotoxicosis, chronic glomerulonephritis, chronic heart failure, history of sarcoidosis, active peptic ulcer of the stomach and duodenum, impaired iron or copper metabolism, thrombosis, tendency to thrombosis, thrombophlebitis, urolithiasis, incurable cobalamin deficiency, children under 18 years of age, period pregnancy and feeding breastfeeding. Interaction with drugs The drug is not recommended to be prescribed together with other multivitamins, since an overdose of the latter in the body is possible. High doses of the drug reduce the effectiveness of tricyclic antidepressants, antipsychotics – phenothiazine derivatives, tubular reabsorption of amphetamine, disrupt the excretion of mexiletine by the kidneys. Due to the possibility of developing hypervitaminosis A, the concomitant use of the drug with other drugs containing vitamin A, or with oral retinoids is not recommended. Retinol reduces the anti-inflammatory effect of glucocorticoids. Do not use simultaneously with nitrites and cholestyramine, because they interfere with the absorption of retinol. Medicines containing iron inhibit the action of vitamin E. Vitamin E cannot be used together with iron, silver, alkaline medicines (such as sodium bicarbonate, trisamine). indirect anticoagulants (such as dicoumarin, neodicoumarin). Alpha-tocopherol acetate enhances the effect of steroidal and non-steroidal anti-inflammatory drugs (such as diclofenac sodium, ibuprofen, prednisolone). Thiamine hydrochloride, influencing the processes of polarization in the area of neuromuscular synapses, can weaken the curare-like effect of muscle relaxants. Pyridoxine hydrochloride weakens the effect of levodopa, prevents or reduces the toxic manifestations of isoniazid and other anti-tuberculosis drugs. When using short-acting sulfonamides with ascorbic acid, the risk of crystalluria increases. With simultaneous use, it enhances the effect of penicillin, increases the absorption of iron, reduces the effectiveness of heparin and indirect anticoagulants, enhances the absorption of aluminum (take into account with simultaneous treatment with antacids containing aluminum). The absorption of ascorbic acid decreases with simultaneous use with oral contraceptives, the use of fruit or vegetable juices, and alkaline drinking. Ascorbic acid can be used only 2 hours after the injection of deferoxamine. Long-term use of large doses of ascorbic acid reduces the effectiveness of treatment with disulfiram. Ascorbic acid increases the total clearance of ethyl alcohol. Medicines of the quinolone series, calcium chloride, salicylates, tetracyclines, corticosteroids with prolonged use reduce the reserves of ascorbic acid in the body. Ascorbic acid increases the excretion of oxalates in the urine and increases the risk of crystalluria in the treatment of salicylates. Riboflavin is incompatible with streptomycin of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). The tricyclic antidepressants imipramine and amitriptyline inhibit the metabolism of riboflavin, especially in the heart. Folic acid reduces plasma concentrations of phenytoin, with antiepileptic drugs, in particular phenobarbital, which causes a decrease in clinical efficacy. Ethanol, cycloserine, glutethimide, and methotrexate may interfere with folate metabolism. The absorption of folic acid decreases with simultaneous use with analgesics, anticonvulsants, antacids, sulfonamides, antibiotics, cytostatics. Cases of reduced or altered absorption may occur with the simultaneous use of cholestyramine and folic acid. Therefore, the drug should be taken 1 hour before or 4-6 hours after taking cholestyramine. Do not use together with mineral acids, reducing agents, as folic acid is inactivated. If you are taking any other medicines, consult your doctor about the possibility of using the drug. Features of the application Before starting treatment, consult your doctor. The drug is not intended for prophylactic use. Taking vitamins does not replace a balanced diet. Women who use high doses of retinol (over 10,000 IU) can plan pregnancy no earlier than 6-12 months later. This is due to the fact that during this time there is a risk of improper development of the fetus under the influence of a high content of vitamin A in the body. It is possible to stain urine yellow, which is a completely harmless factor and is explained by the presence of riboflavin in the drug. Use with caution in patients with kidney disease, with severe liver damage, a history of peptic ulcer of the stomach and duodenum, acute nephritis, cardiac decompensation, cholelithiasis, chronic pancreatitis, coronary heart disease, diabetes mellitus. The drug should be used with caution in patients with neoplasms (except in cases accompanied by megaloblastic anemia). The drug is prescribed with caution in patients with anemia of unknown etiology, since folic acid may interfere with the diagnosis of pernicious anemia by improving the hematological manifestations of the disease, while allowing the progression of neurological complications. When using high doses or long-term use of the drug, it is necessary to control the level of blood pressure. Simultaneous use of the drug with alkaline drink reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid can be impaired in intestinal dyskinesias, enteritis and achilia. Use with caution in patients with glucose-6-phosphate dehydrogenase deficiency. Ascorbic acid may interfere with laboratory test results. For example, when determining the content of glucose, bilirubin in the blood, the activity of transaminases, lactate dehydrogenase. Do not prescribe large doses of the drug to patients with increased blood clotting. Because ascorbic acid increases iron absorption, high doses may be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with a high iron content in the body should use the drug in minimal doses. Since ascorbic acid has a slight stimulating effect, it is not recommended to use the drug at the end of the day. Use during pregnancy or lactation The use of the drug Decamevit during pregnancy and during lactation is not recommended, due to the danger to the fetus of an overdose of vitamin A. The dose of vitamin A should not exceed 5,000 IU for pregnant women and women planning to become pregnant. During pregnancy or lactation, the drug should be used only on the advice of a doctor. Vitamins during pregnancy are better to take those that are specially designed for pregnant women. The ability to influence the reaction rate when driving vehicles or other mechanisms Drivers and operators of complex mechanisms should take into account the possibility of side effects such as dizziness, drowsiness. Children Due to the lack of data on safety and efficacy, the drug should not be used in children. Dosage and administration The drug is prescribed for therapeutic purposes inside, after meals. adults 1 tablet 1-2 times a day. The course of treatment, as a rule, is 20 days. Depending on the indications, repeated courses are possible with breaks between them of 2-3 months. Overdose Symptoms. In case of an overdose of the drug, dyspeptic phenomena (nausea, vomiting, diarrhea, epigastric pain, allergic reactions (itching, skin rash), changes in the skin and hair, headache, drowsiness, lethargy, flushing of the face, irritability, increased excitability of the central nervous system) may occur. , which can cause convulsions.Treatment.Discontinuation of the drug.Therapy is symptomatic.With prolonged use in high doses, inhibition of the function of the insular apparatus of the pancreas may be inhibited, requiring monitoring of the state of the latter.Overdose may lead to changes in the renal excretion of ascorbic and lactic acids during acetylation urine with a risk of precipitation Side effects The drug is generally well tolerated, but sometimes adverse reactions may occur, mainly when used in high doses.Immune system: in people with hypersensitivity, allergic reactions are possible, including anaphylac tic shock, angioedema, hyperthermia; rarely – bronchospasm in persons with hypersensitivity to vitamins A, C, group B. From the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis before the onset of diabetes mellitus. On the part of the skin and subcutaneous tissue: rash, urticaria, itching, redness of the skin, eczema. From the side of the cardiovascular system: arterial hypertension / hypotension. myocardial dystrophy. From the nervous system: headache, dizziness, irritability, fatigue, sleep disturbance, drowsiness, feeling hot. From the gastrointestinal tract: dyspeptic disorders, heartburn, bitterness in the mouth, nausea, vomiting, diarrhea, anorexia; rarely – an increase in the secretion of gastric juice is possible. From the kidneys and urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, the formation of urate, cystine and / or oxalate stones in the kidneys and urinary tract, renal failure. On the part of metabolism: a violation of the metabolism of zinc, copper. From the blood and lymphatic system: thrombocytosis, hyperprothrombinemia, thrombosis, erythrocytopenia, neutrophilic leukocytosis; in patients with deficiency of glucose-6-phosphate dehydrogenase of blood cells, it can cause hemolysis of red blood cells, hemolytic anemia. Others: possible staining of urine in yellow, sweating, blurred vision. With prolonged use of the drug in high doses, the following are possible: irritation of the mucous membrane of the gastrointestinal tract, paresthesia, hyperuricemia, transient increase in the activity of ACT, lactate dehydrogenase, alkaline phosphatase, decreased glucose tolerance, hyperglycemia, impaired renal function, dryness and cracks in the palms and feet , hair loss, seborrheic rashes, tachycardia, arrhythmia. Shelf life 2 years. The drug should not be used after the expiration date indicated on the package. Storage conditions Store in the original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children. Storage conditions Store in the original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children. Holiday conditions Without a prescription. UpakovkaPo 10 tablets in a blister; 2 blisters in a pack. Buy Decamevit tablets p/o No. 10×2 Price for Decamevit tablets p/o No. 10×2
INN | OTHER |
---|---|
The code | 98 470 |
Barcode | 4 820 011 185 147 |
Active substance | Vitamin and mineral complex |
Manufacturer | Kyiv Vitamin Plant PJSC, Ukraine |
Importer | UE "MedPharmInvest", Minsk, Republic of Belarus, Minsk region, Minsk district, Papernyansky village, 50/1-1 district, Dubovlyany village |
Be the first to review “Decamevit tablets p / o №10×2” Cancel reply
Related products
Vitamin - mineral complexes
Doppelherz Active from A to Zinc with peach and passion fruit flavor effervescent tablets №15
$24.00
Vitamin - mineral complexes
Vitax active green tea + vitamins A, C, D, E, group B, capsules No. 30
$28.00
Reviews
There are no reviews yet.