Magne B6 oral solution in ampoules 10ml №10

Magne v6 solution. Release form Solution. INN Magnesium lactate + magnesium pidolate + pyridoxine hydrochloride. FTGMagnesium drug. DescriptionTransparent brown liquid with a caramel smell. Composition One ampoule (10 ml) contains: Active substances: magnesium lactate dihydrate – 186 mg, magnesium pidolate – 936 mg (total content of magnesium (Mg2+) is 100 mg (4.11 mmol)), pyridoxine hydrochloride – 10 mg. Excipients: sodium disulfite (E223), sodium saccharinate (E954), cherry-caramel flavor, purified water. The composition of the cherry-caramel flavoring: alcoholates and alcohol tinctures of raspberry, orange, cocoa, black currant, extracts of coffee, Tonka beans, hemanthus and fenugreek, vanillin, ethylvanillin, maltol (E 636), piperonal, oxyphenylone, acetylmethylcarbinol, diacetyl, isoamyl acetate, gamma nonalactone, ionones, methyl isoeugenol, benzoic aldehyde, caramel (E 150), propylene glycol (E 1520). Pharmacotherapeutic group Mineral additives. Magnesium based products. ATX Code: A12CC. Pharmacological properties Pharmacodynamics Physiological aspects: Magnesium is predominantly an intracellular cation. It reduces the excitability of neurons and neuromuscular transmission of excitation, takes part in many enzymatic processes. Magnesium is an essential element of organs and tissues: bone tissue contains half of the total amount of magnesium contained in the human body. Clinical aspects: Serum magnesium levels: – between 12 and 17 mg/l (1-1.4 mEq/l or 0.5-0.7 mmol/l): indicate a mild magnesium deficiency – below 12 mg/l ( 1 mEq/L or 0.5 mmol/L): indicate severe magnesium deficiency. Deficiency can be: – primary, due to congenital anomaly of magnesium metabolism, – secondary, due to inadequate intake (severe malnutrition, alcoholism, total parenteral nutrition), gastrointestinal absorption disorders (chronic diarrhea, gastrointestinal fistula, hypoparathyroidism) , excessive losses at the renal level (tubular disease, significant polyuria, diuretic abuse, chronic pyelonephritis, primary hyperaldosteronism, cisplatin treatment). Pyridoxine (vitamin B6) is involved in many metabolic processes of the body, in the regulation of the metabolism of the nervous system. The biological properties of pyridoxine are provided by pyridoxal-5-phosphate, which is formed in the body with the participation of the enzyme pyridoxalkinase. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells, which determines the effectiveness of the combination of these substances. Pharmacokinetics Gastrointestinal absorption of magnesium salts occurs in part by a passive mechanism in which salt solubility plays a decisive role. The degree of this absorption does not exceed 50%. Excretion occurs primarily in the urine. Indications for use This medicinal product contains magnesium and is used to correct a deficiency of this element in the body A combination of a number of the following symptoms may indicate a magnesium deficiency: – Nervousness, irritability, mild anxiety, transient fatigue, slight sleep disturbances, intestinal cramps or palpitations (with a healthy heart), – Muscle cramps, tingling sensation Magnesium may help relieve these symptoms. If after one month of treatment there is no improvement, continuation of monotherapy with this drug is impractical. Contraindications The use of the drug is contraindicated in the following cases: – hypersensitivity to one of the components – severe renal insufficiency with creatinine clearance less than 30 ml / minute – co-administration with levodopa. Precautions In case of concomitant calcium deficiency, magnesium deficiency must be corrected before calcium deficiency is eliminated, i.e. before starting calcium supplements. In severe magnesium deficiency and malabsorption, intravenous route of administration should be chosen for treatment. This drug is indicated for oral administration. IT CANNOT BE INJECTED! In moderate renal insufficiency, care should be taken to prevent the risk associated with hypermagnesemia. Due to the presence of sucrose, the drug is contraindicated in fructose intolerance, impaired glucose or galactose absorption syndrome, or sucrase-isomaltase deficiency. Use with caution in gastric ulcer and duodenal ulcer, coronary heart disease. In severe liver damage, pyridoxine in high doses can cause a deterioration in its function. When pyridoxine is used at high doses (> 200 mg/day) for a long time (for several months or in some cases years), sensory neuropathy may develop, which is accompanied by symptoms such as numbness and vestibular disturbances, tremor of the distal extremities and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after the abolition of high doses of vitamin B6. The ampoules contain sulfite, which may cause or worsen allergic-type reactions, including anaphylactic reactions, in patients at risk. Interactions with other medicinal products and other forms of interaction It is imperative that you keep your doctor informed about all the medicines you are taking. Magnesium, not recommended combinations Phosphorus or calcium salts These drugs inhibit the absorption of magnesium from the intestines. Combinations to be considered Oral tetracyclines An interval of at least 3 hours should be observed between oral administration of tetracyclines and magnesium, due to a decrease in the absorption of tetracyclines in the gastrointestinal tract. Oral thrombolytic agents Magnesium weakens their action. Magnesium reduces the absorption of iron. Vitamin B6, non-recommended combinations Levodopa When used simultaneously with levodopa, the effects of levodopa are reduced or completely inhibited. Vitamin B6, combinations to be considered Hormonal contraceptives When used simultaneously with hormonal contraceptives, an increase in the concentration of pyridoxine in the blood plasma is possible. Diuretics With simultaneous use, the action of diuretics is potentiated. Isonicoting hydrazide, penicillamine, cycloserine When used simultaneously with isonicoting hydrazide, penicillamine, cycloserine, the effectiveness of pyridoxine may decrease. Phenytoin, phenobarbital With simultaneous use with phenytoin, phenobarbital, a decrease in plasma concentrations of phenytoin and phenobarbital is possible. Pregnancy and breast-feeding Pregnancy This medicine can be used at any stage of pregnancy if necessary. If, during treatment with the drug, you find that you are pregnant, consult your doctor who will decide whether you need to continue treatment. Breastfeeding period The use of magnesium and vitamin B6 contained in the preparation is considered compatible with the lactation period. Data on this subject are limited to the maximum daily dose of vitamin B6. The recommended dose of vitamin B6 during lactation is no more than 20 mg per day. Influence on the ability to drive vehicles or other mechanisms There are no special recommendations. Dosage and Administration This medicinal product is indicated for oral administration. IT CANNOT BE INJECTED! The contents of the ampoules should be diluted in half a glass of water. Adults: 3-4 ampoules per day, divided into 2-3 doses with meals. Children weighing over 10 kg (aged about 1 year and older): 10-30 mg / kg / day (0.4-1.2 mmol / kg / day), i.e. 1-4 ampoules per day, divided into 2 -3 doses during meals. If you forget to take Magne B6, do not take a double dose to make up for the missed one! Treatment should be discontinued after normalization of magnesium levels in the blood. ATTENTION: AMPOULES ARE SELF-CRUSHING, DO NOT REQUIRE THE USE OF A FILE! To open the ampoule, take it by the tip (you can pre-cover it with a piece of cloth) and break off the tip with a sharp movement. Follow the instructions in the picture! Overdose Oral overdose of magnesium usually does not lead to toxic reactions if the kidneys are functioning normally. However, magnesium poisoning can develop in case of kidney failure. Toxic effects depend on the level of magnesium in the blood, and their symptoms are as follows: – drop in blood pressure, – nausea, vomiting, – CNS depression, impaired reflexes, – ECG changes, – respiratory depression, coma, cardiac arrest and respiratory paralysis, – anuric syndrome . When taking a large dose – the risk of anuric syndrome. Treatment: rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis. Side effects Like all medicines, this drug may cause some people to experience some degree of discomfort. – diarrhea – abdominal pain – skin reactions – allergic reactions Due to the presence of sodium disulfite (E 223) in this form of release of the drug (solution for oral administration), there is a risk of allergic reactions, up to anaphylactic, and bronchospasm. Reporting Adverse Reactions If you experience any adverse reactions, please consult your physician. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage conditions Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life 3 years. Do not take after the expiration date stated on the packaging. Conditions for dispensing from pharmacies It is dispensed without a prescription. Packing 10 ampoules of type III yellow glass, 10 ml capacity, with two or one break line at each of the two ends of the ampoule, together with instructions for use in a cardboard box. Buy Magne B6 oral solution in 10 ml ampoules No. 10 Price for Magne B6 solution for oral administration in ampoules 10ml No. 10 Instructions for use for Magne B6 solution for oral administration in ampoules 10 ml No. 10