Magne B6 Forte tablets p/o 100mg/10mg №20×2

Name:
Magne in the 6th fort. Forms of release Tablets. INN Magnesium citrate + pyridoxine hydrochloride. Composition 1 tablet contains: active ingredients: magnesium citrate – 618.43 mg, which corresponds to 100 mg of magnesium (Mg ++), pyridoxine hydrochloride – 10 mg; excipients: anhydrous lactose, macrogol-6000 (E1521), magnesium stearate (E572), hypromellose 6 mPa.s (E 464), titanium dioxide (E171), talc (E553).
Description:
White oval film-coated tablets. Pharmacotherapeutic group Mineral additives. Magnesium based products. ATX Code: A12CC. Pharmacological properties Pharmacodynamics Physiological aspects: Magnesium is predominantly an intracellular cation. Magnesium reduces the excitability of neurons, participates in neuromuscular synaptic transmission, muscle contraction and regulation of enzymatic processes. Magnesium is a macronutrient; half of the magnesium contained in the body accumulates in bone tissue. Clinical aspects: Serum magnesium levels: – between 12 and 17 mg/l (1-1.4 mEq/l or 0.5-0.7 mmol/l): indicate a mild magnesium deficiency – below 12 mg/l ( 1 mEq/L or 0.5 mmol/L): indicate severe magnesium deficiency. Deficiency can be: – primary, due to a congenital anomaly of metabolism (chronic congenital hypomagnesemia), – secondary, due to – inadequate intake (severe malnutrition, alcoholism, exclusively parenteral nutrition), – gastrointestinal absorption disorders (chronic diarrhea, gastrointestinal – intestinal fistula, hypoparathyroidism), – excessive losses at the renal level (tubular disease, severe polyuria, diuretic abuse, chronic pyelonephritis, primary hyperaldosteronism, treatment with cisplatin). Pyridoxine (vitamin B6) is involved in many metabolic processes, including those in the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Pharmacokinetics Gastrointestinal absorption of magnesium salts occurs in part by a passive mechanism in which salt solubility plays a decisive role. The degree of this absorption does not exceed 50%. Excretion occurs primarily in the urine. Directions for use This medicinal product contains magnesium. A combination of the following symptoms may indicate a magnesium deficiency: – Nervousness, irritability, mild anxiety, transient fatigue, mild sleep disturbances – Signs of anxiety such as gastrointestinal cramps or heart palpitations (with a healthy heart) – Muscle cramps, goosebumps skin Administration of magnesium can help relieve these symptoms. If after one month of treatment there is no improvement, continuation of monotherapy with this drug is impractical. Contraindications The use of the drug is contraindicated in the following cases: – hypersensitivity to one of the components (see section “Composition”) – severe renal failure (creatinine clearance less than 30 ml / minute) Dosage and administration Tablets should be taken whole with a glass of water. Adults: 3-4 tablets per day, divided into 2-3 doses, with meals. Children over 6 years of age (about 20 kg): 10-30 mg/kg/day (0.4-1.2 mmol/kg/day), i.e. 2-4 tablets per day, divided into 2-3 doses , while eating. Usually the duration of treatment is one month. Side effects Undesirable reactions that may occur with the use of the drug are classified according to system organ classes and frequency indicated as: very often (≥ 1/10), often (≥ 1/100, but < 1/10), infrequently (≥ 1 /1000 but < 1/100), rare (≥ 1/10000 but < 1/1000), very rare (< 1/10000), frequency unknown (frequency cannot be estimated from the available data). Immune system disorders: Frequency unknown: hypersensitivity. Gastrointestinal disorders: Frequency unknown: diarrhea*, abdominal pain*. Skin and subcutaneous tissue disorders: Frequency unknown: skin reactions. * - undesirable reactions caused by the use of magnesium. Reporting adverse reactions It is important to report suspected adverse reactions after registration of a medicinal product in order to ensure continuous monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are encouraged to report any suspected adverse drug reactions through national adverse drug reaction and drug failure reporting systems. Special instructions and precautions In case of concomitant calcium deficiency, magnesium deficiency must be eliminated before the use of calcium preparations. Due to the presence of lactose in the tablets, the drug should not be taken in case of galactose intolerance, impaired glucose or galactose absorption syndrome, or lactase deficiency. Excessive consumption of pyridoxine can cause sensory neuropathy, which occurs with long-term use of pyridoxine and / or chronic use of high doses of pyridoxine over a long period of time (several months or years). This condition gradually disappears after discontinuation of treatment with the drug (see section "Overdose") THE TABLETS ARE INTENDED FOR ADULTS AND CHILDREN OVER 6 YEARS. There are dosage forms more suitable for children under 6 years of age. In moderate renal insufficiency, care should be taken to prevent the risk associated with hypermagnesemia. Overdose Magnesium overdose Oral magnesium overdose does not usually result in toxic reactions if the kidneys are functioning normally. However, magnesium poisoning can develop in case of kidney failure. Toxic effects depend on the level of magnesium in the blood, and their symptoms are as follows: - drop in blood pressure - nausea, vomiting - depression of the central nervous system, decreased reflexes - ECG abnormalities - respiratory depression, coma, cardiac arrest and respiratory paralysis - anuric syndrome. Treatment: rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis. Pyridoxine overdose Sensory axonal neuropathy is the main effect that can occur with long-term and/or chronic use of high doses of pyridoxine (over several months or years). Signs and symptoms In particular, the following symptoms have been reported: paresthesia, dysesthesia, hypoesthesia, sensory deficits, pain in the extremities, involuntary muscle contractions, burning sensation, imbalance, unsteady gait, tremors in the arms and legs, and progressive sensory ataxia (difficulty in coordinating movements). ). Treatment: neurological symptoms are reversible and gradually disappear after discontinuation of drug treatment. Pregnancy and lactation Pregnancy If necessary, magnesium can be used at any stage of pregnancy. Despite the lack of large-scale studies, the available clinical experience is encouraging. Breast-feeding The use of magnesium and vitamin B6 contained in the preparation is considered compatible with lactation. The maximum recommended dose of vitamin B6 during lactation is no more than 20 mg per day. Exceeding this dose is not recommended. Interaction with other drugs and other forms of interaction Not recommended combinations - Phosphate or calcium salts These substances interfere with the absorption of magnesium in the intestine. Influence on the ability to drive vehicles or other mechanisms There are no special recommendations. Packing: 20 tablets in blisters (PVC-PE-PVDC/aluminium), two blisters in a carton box with instructions for medical use. Storage conditionsStore at a temperature not exceeding 30°C. Keep out of the reach of children. Read the instructions carefully before use. Shelf life 2 years. Do not use after the expiry date stated on the packaging. Conditions for dispensing from pharmacies It is dispensed without a prescription. Buy Magne B6 Forte tablets p/o 100mg/10mg №20x2 Price for Magne B6 Forte tablets p/o 100mg/10mg №20x2