Name:
Duovit dragee in blister packs No. 10×4
Description:
Red dragee: hard, smooth red dragee with a sweet and sour taste. Blue pills: hard, smooth blue pills. The main active substance Release form 4 blisters of 10 tablets in a cardboard box with a leaflet. Each blister contains 5 red pills and 5 blue pills. Dosage Adults and children over 10 years of age are recommended to take 1 red tablet (vitamins) and 1 blue tablet (minerals) per day. Pharmacological action A combined preparation containing a complex of 11 vitamins and 8 minerals, which are important factors in metabolic processes. One red and blue pills contain vitamins and minerals in quantities that satisfy the daily needs of the body. For better assimilation of the vitamin-mineral complex and preservation of the activity of the main components, vitamins and minerals are separated in pills of different colors. Vitamins are contained in red pills, minerals – in blue pills. Vitamin A is involved in the synthesis of various substances (proteins, lipids, mucopolysaccharides) and ensures the normal function of the skin, mucous membranes, and the organ of vision. Vitamin D3 plays an important role in maintaining the balance of calcium and phosphorus in the body. With its deficiency, the calcium content in the bone tissue decreases (osteoporosis). Vitamin B1 normalizes the activity of the heart and contributes to the normal functioning of the nervous system. Vitamin B2 promotes tissue regeneration processes, including skin cells. Vitamin B6 helps maintain the structure and function of bones, teeth, gums, affects erythropoiesis, and contributes to the normal functioning of the nervous system. Vitamin B9 (folic acid) stimulates erythropoiesis. Vitamin B12 is involved in erythropoiesis, contributes to the normal functioning of the nervous system. B vitamins are involved in the formation of various enzymes that regulate different types of metabolism in the body. Vitamin PP (nicotinamide) – a coenzyme involved in protein metabolism in the synthesis of fatty acids and cholesterol, in energy production, is necessary for the normal functioning of the central nervous system. Vitamin E is a natural antioxidant. Prevents increased blood clotting and favorably affects peripheral circulation. Participates in the synthesis of proteins and hemoglobin, the process of cell growth, the function of skeletal muscles, the heart and blood vessels, and the sex glands. Vitamin C is involved in the oxidation of a number of biologically active substances, regulation of metabolism in connective tissue, carbohydrate metabolism, blood clotting and tissue regeneration, stimulates the formation of steroid hormones, and normalizes capillary permeability. Vitamin C increases the body’s resistance to infections, reduces inflammatory reactions. Calcium is involved in the formation of bone tissue, blood clotting, the transmission of nerve impulses, the contraction of skeletal and smooth muscles, and the normal functioning of the heart. It also promotes iron absorption. Magnesium is involved in the formation of muscle and bone tissue, and also takes part in protein synthesis. Iron is part of the hemoglobin molecule, is involved in the transfer of oxygen in the body and prevents the development of anemia. Phosphorus, along with calcium, is involved in the formation of bones and teeth, and is also involved in the processes of energy metabolism. Manganese promotes bone mineralization. Copper is essential for normal red blood cell function and iron metabolism. Zinc is essential for tissue regeneration and is part of some hormones, including insulin. Pharmacokinetics Separate studies on the pharmacokinetics of Duovit dragees have not been conducted, however, the absorption, distribution and excretion of individual vitamins and minerals in the body are well known and described in the literature. Water-soluble vitamins (vitamins B, vitamin C and biotin) are well absorbed in doses that are within the limits recommended per day. The excess is excreted in the urine and, to a lesser extent, in the feces. Vitamins of this group are stored in the body in limited quantities, so they must be constantly supplied with food to achieve the appropriate tissue concentration. In the presence of fats, vitamins A and D are well absorbed in the small intestine. The absorption of vitamin E is relatively low (from 25% to 85% of the dose). These vitamins are stored in significant amounts in the liver and are therefore more toxic than water-soluble vitamins. With a lack of minerals and trace elements in the body, their absorption increases. Calcium, magnesium, copper, molybdenum ions are relatively well absorbed (up to 30% calcium ions and from 20 to 65% magnesium ions), iron, zinc, and manganese are less absorbed. The average value of absorption with food of zinc is from 10 to 50%, iron from 1 to 30% and manganese 5%. The intake of a large amount of zinc ions with food reduces the absorption of iron and copper ions and promotes the absorption of manganese ions to a lesser extent, while magnesium ions have the opposite effect. Co-administration of vitamins can also affect the absorption of minerals. Vitamin C promotes the absorption of iron ions, vitamin D, the absorption of calcium, phosphorus and magnesium ions. Excess iron ions accumulate in the liver, excess calcium, phosphorus and magnesium are excreted in the urine, excess zinc, cobalt and copper are excreted through the gastrointestinal tract. Indications for use Treatment of hypo- and avitaminosis caused by insufficient intake or increased need for vitamins. Dosage and administration Adults and children over 10 years of age are recommended to take 1 red tablet (vitamins) and 1 blue tablet (minerals) per day. The dragee should be swallowed whole with a small amount of water. The drug is recommended to be taken after breakfast. Use during pregnancy and lactation Use during pregnancy is contraindicated and not recommended during breastfeeding. Vitamin A in doses above 1000 IU per day causes birth defects when taken during pregnancy. It must be taken into account that the vitamins and minerals taken are excreted with mother’s milk, especially if the child receives other vitamin-mineral complexes. The risk of exposure to the infant cannot be excluded and this must be taken into account if the infant is receiving any other nutritional supplements. High doses of vitamin B6 may inhibit milk production. Precautions Before using vitamins, vitamin-mineral and / or mineral preparations, consult your doctor. Patients suffering from diabetes can be prescribed Duovit tablets, but it should be taken into account that the daily dose of the drug contains 1.6 g of sugar (one tablet contains approximately 0.8 g of sugar). Duovit should be taken after meals – otherwise, discomfort from the gastrointestinal tract may appear. Simultaneous use of Duovit with products containing vitamin A can lead to hypervitaminosis. Taking vitamins does not replace a balanced diet. Do not exceed the indicated dosage. High doses of some components, especially vitamin A, vitamin D, iron and copper, can be hazardous to health. It is not recommended to use with other vitamin preparations in order to avoid overdose and the development of side effects. Care must be taken when taking the drug in patients with a history of liver dysfunction or disease, cholelithiasis, diabetes mellitus, gout, arrhythmias, migraines, alcohol abuse, gastric ulcer in the acute stage, the presence of neoplasms. Possible staining of urine in yellow, which is an absolutely harmless factor and is explained by the presence of riboflavin in the preparation. Special precautions regarding excipients The drug contains lactose, sorbitol, glucose and sucrose. Patients with rare hereditary problems of fructose, galactose or sucrose-isomaltase intolerance, lactose deficiency or malabsorption of glucose-galactose should not take the drug. Azo dyes E124 and E110 can cause allergic reactions. Interaction with other drugs There was no effect on the ability to drive a car or potentially dangerous mechanisms. Duovit is not recommended to be taken together with drugs containing aromatic rings (for example, tetracyclines, quinolones, cholesterol), and with antacids. The combined use of minerals and antibiotics from the tetracycline group is not recommended, since the absorption of the latter decreases when used together. When combined with antacids, the absorption of minerals slows down. If concomitant treatment is necessary, then the interval between taking tetracyclines or antacid drugs and Duovit should be at least 3 hours. Simultaneous use of Duovit with products containing vitamin A can lead to hypervitaminosis. While taking the drug, you should refrain from taking alcohol, since alcohol reduces the absorption of some vitamins. Retinol reduces the anti-inflammatory effect of glucocorticoids. The combined use of levodopa with pyridoxine is not recommended, since the antiparkinsonian effects level pyridoxine; this problem does not occur when combined with carbidopa-levodopa or with peripheral decarboxylase inhibitors. Colchicine, cimetidine, calcium preparations, ethyl alcohol, neomycin, para-aminosalicylic acid, biguanides, cholesterolamine, potassium chloride and methyldopa reduce the absorption of vitamin B12. Serum concentrations of cyanocobalamin may be reduced by oral contraceptives. Folic acid can reduce plasma concentrations of anticonvulsants, in particular phenytoin, phenobarbital and primidone, resulting in a mutual decrease in clinical efficacy. Therefore, patients receiving antiepileptic therapy may require dose adjustments and close medical supervision when taking folic acid. Preparations containing folic acid or its derivatives may reduce the effectiveness of methotrexate. Contraindications Hypersensitivity to the components of the drug. Hypervitaminosis A and D. Composition 1 red pill contains: Vitamin A (Retinolum) 5000 IU Vitamin D3 (Cholecalciferolum) 200 IU Vitamin C (Acidum ascorbicum) 60 mg Vitamin PP (Nicotinamidum) 13 mg Vitamin E (?-Tocopheroli acetas) 10 mg Calcium pantothenate (Calcii pantothenas) 5 mg Vitamin B6 (Pyridoxini chloridum) 2 mg Vitamin B2 (Riboflavinum) 1.2 mg Vitamin B1 (Thiamini nitras) 1 mg Folic acid (Acidum folicum) 0.4 mg Vitamin B12 (Cyanocobalaminum) 3 mcg 1 blue dragee contains: Calcium in the form of calcium hydrogen phosphate dihydrate 15 mg Phosphorus in the form of calcium hydrogen phosphate dihydrate 12 mg Iron in the form of iron (II) fumarate 10 mg Copper in the form of copper (II) sulfate pentahydrate 1 mg Zinc in the form of zinc sulfate heptahydrate 3 mg Magnesium in the form of magnesium lactate dihydrate 20 mg Manganese in the form of manganese (II) sulfate monohydrate 1 mg Molybdenum in the form of sodium molybdate dihydrate 0.1 mg Excipients: lactose monohydrate, orange oil flavor, polysorbate 80, glycerin, castor oil purified, sorbitol, liquid glucose, antifoaming agent 1510, magnesium stearate, red dye (E124), orange dye (E110), indigotin dye (E132), capol 600 pharma, sucrose, liquid paraffin, povidone. Overdose Most of the symptoms related to overdose relate to the concomitant use of large doses of drugs containing one and / or more vitamins. Acute or prolonged overdose can lead to hypervitaminosis A and D and hypercalcemia, as well as cause toxic effects of iron and copper. Atypical initial symptoms such as sudden headache, confusion, and gastrointestinal disturbances such as constipation, diarrhea, nausea, and vomiting may be signs of acute overdose. Treatment: oral administration of activated charcoal, gastric lavage, symptomatic therapy. Side effects Side effects are classified into the following groups depending on the frequency of occurrence: very common (? 1/10), frequent (? 1/100 to < 1/10), infrequent (? 1/1000 to < 1/100), rare ( ≥ 1/10,000 to < 1/1,000) very rare (< 1/10,000); frequency unknown (cannot be estimated from available data). Within each group, side effects are presented in decreasing order of significance. The frequency of side effects is listed by individual organ systems. The recommended doses are usually well tolerated. In some individuals, the following adverse reactions may very rarely occur: From the immune system: hypersensitivity reactions to the components of the drug, including anaphylactic shock, bronchospasm; From the nervous system: headache, dizziness, drowsiness, insomnia. On the part of the organs of vision: blurred vision. From the gastrointestinal tract: dyspepsia, nausea, vomiting, stomach pain, constipation, diarrhea, increased secretion of gastric juice. From the skin of the subcutaneous tissue: rash, urticaria, itching, redness. From the side of the kidneys and urinary tract: hypercalciuria. Storage conditions Store at a temperature not exceeding 2 5 ° C in a place protected from moisture and light. Keep out of reach of children. Buy Duovit dragee No. 10x4 Price for Duovit dragee No. 10x4 Instructions for use for Duovit dragee No. 10x4
INN | POLYVITAMIN+MULTIMINERAL |
---|---|
The code | 236 |
Barcode | 3 838 989 521 349 |
Active substance | Vitamin and mineral complex |
Manufacturer | Krka dd, Slovenia |
Importer | IOOO Interfarmaks 223028 Minsk region, Minsk district, Zhdanovichsky s / s, ag. Zhdanovichi, st. Star, 19a-5, room. 5-2 |
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