Lactulose Pharmland syrup 667mg/ml 500ml №1

Name:
Lactulose Pharmland syrup 667mg/ml in 500ml vial in pack No. 1
Description:
Transparent viscous liquid from light yellow to brownish-yellow color, sweet in taste. The main active ingredient is lactulose in the form of lactulose Release form Syrup Dosage 500 ml Pharmacological properties Lactulose is a synthetic derivative of lactose. It does not break down in the stomach and in the small intestine due to the lack of appropriate enzymes and is practically not absorbed. Once in the intestines, it stimulates peristalsis, improves the absorption of phosphates and calcium salts, increases the diffusion of ammonia from the blood into the intestines and promotes its excretion from the body. In the large intestine, under the influence of the intestinal flora, lactulose is broken down into low molecular weight organic acids – mainly lactic acid and partially formic and acetic acids. At the same time, osmotic pressure increases and the pH in the lumen of the large intestine decreases, the volume of feces increases, which stimulates the peristalsis of the large intestine and normalizes the consistency of feces. This helps to eliminate constipation and restore the physiological rhythm of bowel movements. The removal of bound ammonium ions is carried out with the development of a laxative effect. The laxative effect appears 24 to 48 hours after ingestion. In addition, lactulose removes bile acids with feces, as a result, the content of cholesterol in the blood and bile decreases. In hepatic encephalopathy or hepatic precoma/coma, the effect is attributed to the suppression of proteolytic bacteria by increasing the number of acidophilus bacteria (eg, lactobacilli); the transition of ammonia to the ionic form due to acidification of the contents of the colon; bowel movements due to a decrease in pH in the colon and an osmotic effect; as well as the reduction of nitrogen-containing toxic substances by stimulating bacteria that utilize ammonia for bacterial protein synthesis. Lactulose, as a prebiotic substance, promotes the growth of bifidobacteria and lactobacilli, while the growth of opportunistic clostridia and E. coli can be suppressed. This contributes to a favorable balance of intestinal microflora. Indications for use – constipation: regulation of the physiological rhythm of bowel movements; – softening of the stool for medical purposes (hemorrhoids, operations on the colon and anus, in the postoperative period); – hepatic encephalopathy: treatment and prevention of hepatic precoma or coma. Dosage and administration Lactulose Pharmland is taken orally. The duration of treatment and doses are set by the doctor individually. Lactulose Pharmland can be taken both diluted and undiluted. It is necessary to immediately swallow the accepted single dose, without holding it in the mouth. All dosages must be selected individually. In the case of a single daily dose, it must be taken at the same time, for example, during breakfast. During therapy with laxatives, it is recommended to take a sufficient amount of fluid (1.5-2 liters) per day. Prevention of constipation: Should be taken 1 time per day. The clinical effect occurs in 1-2 days. The dose is increased if within 2-3 days of taking the drug there is no improvement in the patient’s condition. Adults and adolescents: the initial dose is 15-45 ml, the maintenance dose is 15-30 ml. Children: up to 1 year, the initial dose is up to 5 ml, the maintenance dose is up to 5 ml; from 1 year to 6 years, the initial dose is 5-10 ml, the maintenance dose is 5-10 ml; from 7 to 14 years, the initial dose is 15 ml, the maintenance dose is 10-15 ml. As a rule, the dose can be reduced after 2 days of administration, depending on the needs of the patient. Stool Softener Application: The dosage of the stool softener product is the same as for constipation. In the prevention of hepatic encephalopathy, hepatic precoma or coma (adults): Initial dose of 30-45 ml 3-4 times a day, and then switch to an individually selected maintenance dose so that soft stools are 2-3 times a day. Children The safety and efficacy of use in children (under 18 years of age) with hepatic encephalopathy has not been established due to lack of data. Elderly patients and patients with renal or hepatic insufficiency: There are no special dosage recommendations, since systemic exposure to lactulose is negligible. Use during pregnancy and lactation Before using the drug, pregnant and lactating women should consult a doctor. If necessary, the drug can be prescribed during pregnancy and lactation, since the systemic effect of lactulose is negligible. Impact on reproductive function is not expected. Precautions In case of abdominal pain of unknown origin, before starting treatment or the absence of a therapeutic effect a few days after starting the drug, you should consult your doctor. Lactulose should be used with caution in patients with lactose intolerance. The dose usually used in the treatment of constipation does not require adjustment for patients with diabetes mellitus. In the treatment of hepatic encephalopathy, higher doses are usually prescribed, which should be taken into account in relation to diabetes mellitus. Chronic unadjusted doses and abuse can lead to diarrhea and fluid and electrolyte imbalance. It must be taken into account that the drug contains lactose, galactose and a small amount of fructose, therefore this drug should not be prescribed to patients with galactose or fructose intolerance, lactase deficiency or glucose-galactose malabsorption. Lactulose can be used in young children and infants only in exceptional cases under the supervision of a physician. Taking lactulose in children can cause a violation of the emptying reflex. Interaction with other drugs Interaction studies with other drugs have not been conducted. Contraindications – hypersensitivity to the components of the drug; – galactosemia; – obstruction of the gastrointestinal tract, perforation or risk of perforation of the gastrointestinal tract. Composition 1 ml of syrup contains the active substance: lactulose in the form of lactulose (liquid) – 667 mg. Overdose Symptoms: when using a very high dose, diarrhea, pain in the abdomen are possible. Treatment: reduce the dose or stop taking the drug. Large fluid loss due to diarrhea or vomiting may require correction of the electrolyte imbalance. Side effect In the first days of taking lactulose, flatulence may occur. It usually disappears after a few days. In the case of the use of high doses for a long time in the treatment of hepatic encephalopathy, the patient may develop electrolyte imbalance due to diarrhea. If the recommended doses are exceeded, pain in the abdomen, diarrhea may occur, which requires a dose reduction. The frequency of these undesirable effects: very often ≥1 / 10; often ≥1/100 to ˂1/10; infrequently from ≥1/1000 to ˂1/100; rarely ≥1/10000 to ˂1/1000; very rarely ˂1/10000. From the gastrointestinal tract: very often – diarrhea; often – flatulence, abdominal pain, nausea, vomiting. Influence on the results of laboratory and instrumental studies: infrequently – electrolyte imbalance due to diarrhea. Storage conditionsStore at a temperature not exceeding 25ºС. Keep out of the reach of children. Buy Lactulose Farmland syrup 667mg/ml 500ml №1