Hepa-Merz granules for application in pack. 5g per pack #30

Name:
Hepa-Merz granules dprig. r-ra dpr. ext. in pak.5g in pack. №30
Description:
Granules from light orange to orange. The main active ingredient is L-ornithine-L-aspartate 3.00 g. Release form 30 sachets (5 g) of paper-polyethylene-aluminum-polyethylene film, together with instructions for use, in a cardboard box. Dosage 5 g Precautions Prescribe the drug with caution to patients involved in potentially hazardous activities that require increased attention and speed of psychomotor reactions. Pharmacodynamics The drug normalizes the detoxification function of the liver, reducing the elevated level of ammonia in the body caused by liver diseases (cirrhosis, hepatitis, tumors, fatty degeneration of the liver, portal hypertension with shunting, congenital shunts, etc.) manifesting signs of hepatic encephalopathy. The causes of hepatic encephalopathy, and therefore elevated levels of ammonia in the body, can also be: internal gastrointestinal bleeding; infections and inflammation of the respiratory and digestive organs; long-term medication; radiation and chemotherapy; excessive alcohol consumption; toxic poisoning of various origins; extensive injuries or burns; sepsis; violation of water and electrolyte balance in the body; surgical intervention; excess protein intake. The action of the drug is associated with its participation in the ornithine Krebs urea cycle (activates the cycle, restoring the activity of liver cell enzymes: carbamoyl transferase and carbamoyl phosphate synthetase). Orinithine and aspartate are substrates of the urea synthesis cycle required for ammonia detoxification. Ornithine in periportal hepatocytes is involved in the synthesis of urea, and aspartate, in turn, in perivenous hepatocytes, muscles and the brain in the synthesis of glutamine, thereby ensuring the neutralization of ammonia toxic to the body. The drug promotes the production of insulin and growth hormone. Improves protein metabolism in diseases requiring parenteral nutrition. Pharmacokinetics L-ornithine-L-aspartate quickly dissociates into ornithine and aspartate, which are absorbed in the small intestine by active transport through the intestinal epithelium and begin to act within 15-25 minutes, having a short half-life. It is excreted in the urine through the urea cycle. Indications for use Treatment of diseases and complications associated with a violation of the detoxification function of the liver (for example, cirrhosis of the liver) with symptoms of latent and overt renal encephalopathy. Dosage and administration Inside, 1-2 sachets of granules dissolved in 200 ml of liquid, 2-3 times a day, after meals. As a liquid, you can use water, tea or juice. Use during pregnancy and lactation Hepa-Merz granules for oral solution should not be used during pregnancy, since there are insufficient data on the effect of the drug on the fetus. The use of the drug during breastfeeding should be avoided, because. it is not known whether the active substance passes into breast milk. If treatment with the drug is necessary, then its use is possible only under the strict supervision of a physician. Interaction with other drugs Interactions with drugs of other groups have not been identified. Contraindications Hypersensitivity to L-ornithine-L-aspartate or other components of the drug. Severe renal failure (with a creatinine value of more than 3.0 mg / 100 ml). Composition 5 g of granules (1 sachet) contain: Active ingredient: L-ornithine-L-aspartate 3.00 g , fructose. Overdose Signs of intoxication in case of overdose are not described. Side effects Undesirable reactions usually pass quickly and do not require discontinuation of the drug. From the gastrointestinal tract: infrequently – nausea, vomiting, abdominal pain, flatulence, diarrhea. On the part of the musculoskeletal and connective tissue: Very rarely: pain in the extremities. Orange yellow dye can cause allergic reactions. Storage conditionsAt a temperature not higher than 25°C. In a place inaccessible to children. Buy Hepa-Merz granules d/prig.r-ra d/pr.vn. in pack. 5g per pack No. 30 Price for Hepa-Merz granules for injection solution for injection. in pack. 5g per pack No. 30Instruction for use for Hepa-Merz granules for application solution for pr.vn. in pack. 5g per pack #30