Exoderil solution for external use 10mg/ml 20ml №1

Name:
Exoderil solution for nar.prim.10mg/ml in vial 20ml in pack No. 1 Main active ingredientNaftifin Release formsolution Composition1 ml of the solution contains: Active substance: naftifine hydrochloride – 10 mg. Excipients: propylene glycol, ethanol, purified water.
Description:
Transparent, colorless or slightly yellow solution with an ethanol odor. Pharmacological properties Pharmacodynamics Exoderil contains the active substance naftifine and is intended for external use in mycoses. The fungicidal action of naftifine is based on the blockade of the synthesis of ergosterol (a membrane component) by suppressing the synthesis of the enzyme squalene epoxidase. Under in vitro conditions, naftifine demonstrates fungicidal activity against the following organisms: Trichophyton spp., Microsporon spp., Epidermophyton floccosum. Naftifine is moderately active against yeast (Candida species), mold (Aspergillus species) and other fungi (eg Sporothrix schenkii). It also exhibits antibacterial activity against gram-positive and gram-negative microorganisms, which often accompany mycoses. In clinical use, the anti-inflammatory effect of naftifine was noted, due to which signs of inflammation, especially itching, quickly disappear. Pharmacokinetics When applied to the skin, only 4% of the dose is absorbed. Therefore, the systemic exposure is very low. In plasma and urine, naftifine is found in trace amounts. Indications for use Local treatment of fungal infections caused by pathogens sensitive to naftifine: – fungal infections of the skin and skin folds (tinea manuum, tinea pedis, tinea corporis, tinea inguinalis), with or without associated itching; – fungal nail infections (onychomycosis, tinea unguium); – skin candidiasis; – pityriasis versicolor (pityriasis versicolor); Contraindications Hypersensitivity to naftifine, propylene glycol or other excipients of the drug. Use during pregnancy and lactation As a precaution, the use of Exoderil during pregnancy and lactation should be avoided. Dosage and administration Exoderil is intended only for external use on the skin or nails. Dosing Apply once a day. The affected skin and adjacent areas are cleaned, dried, then thoroughly moistened with a solution directly from the bottle or with a cotton swab. For the treatment of fungal infections of the nails, apply twice a day, applying from the side of the free edge of the nail. Before the first application of the solution, the affected part of the nail is removed as much as possible with scissors and a nail file. Children and adolescents: the safety and efficacy of naftifine in children and adolescents under 18 years of age has not been proven (experience is insufficient) Patients with renal or hepatic insufficiency: dose adjustment is not required. Elderly patients: dose adjustment is not required. Duration of use To prevent recurrence of infection, treatment is continued for at least two more weeks after clinical recovery. Patients should be informed about the necessary hygiene measures to prevent re-infection. Side effects To assess the frequency of side effects, the following classification was adopted: very frequent (?1/10), frequent (?1/100<1/10), infrequent (?1/1000<1/100), rare (?1/10000< 1/1000), very rare (<1/10000), frequency unknown (cannot be calculated from available data). General disorders and disorders at the injection site Frequency unknown: sensation of dryness, burning or redness. Overdose Acute overdose and systemic intoxication with external use of naftifine are unlikely. In case of accidental ingestion, appropriate symptomatic treatment is recommended. Interaction with other drugs Interactions with other medicinal substances or alcohol have not been noted. Precautions Exoderil solution is not intended for use in ophthalmology. The solution should not be used on open wounds or cracks. The product contains propylene glycol, which may cause skin irritation. The drug is applied undiluted and not mixed with other topical preparations, because due to the reduced concentration, the effectiveness of the active substance may be insufficient. It is not phototoxic and does not cause photosensitivity. Storage conditionsStore at a temperature not exceeding 30°C. Store the opened vial for no more than 28 days at a temperature not exceeding 25°C. Keep out of the reach of children. Buy Exoderil solution for external use 10mg/ml 20ml No. 1 Price for Exoderil solution for external use 10mg/ml 20ml No. 1