Evkazolin Aqua nasal spray 1mg/g 10g №1

Name:
Evkazolin Aqua spray 1mg/g in vial with dosage 10g in pack No. 1
Description:
When leaving the bottle through a dosing pump with a nasal nebulizer, the drug is sprayed in the form of an aerosol jet that has a specific odor and is a liquid particles dispersed in the air. The main active ingredient 1 g of the spray contains xylometazoline hydrochloride in terms of 100% substance 1 mg Release form Spray Dosage 10 g Pharmacological properties Pharmacodynamics Xylometazoline is a sympathomimetic agent acting on α-adrenergic receptors. Xylometazoline, when applied nasally, causes constriction of the blood vessels of the nasal mucosa and adjacent areas of the nasopharynx, thus eliminating swelling and hyperemia of the nasal and nasopharyngeal mucosa, and also reduces the associated increased secretion of mucus and facilitates the removal of blocked secretions from the nose, which leads to nasal clearing. passages and facilitate nasal breathing. The effect of the drug begins within 2 minutes after application and lasts up to 10 hours (for example, throughout the night). The drug is well tolerated by patients with sensitive mucous membranes and does not reduce mucociliary function. Studies have shown that xylometazoline reduces the infectivity of human rhinovirus, which is associated with the common cold. Pharmacokinetics When applied topically, xylometazoline is practically not absorbed, the concentration of xylometazoline in the blood plasma is so low that it is practically not detected (the concentration in the blood plasma is close to the detection limit). Xylometazoline is not mutagenic. Also, in animal studies, no teratogenic effect of xylometazoline was detected. Indications for use For the symptomatic relief of nasal congestion, perennial and allergic rhinitis (including hay fever), sinusitis. Dosage and administrationEvkazolin Aqua, nasal spray, for adults and children over 12 years of age. Adults and children over 12 years of age: 1 spray in each nasal passage up to 3 times daily as needed. Apply no more than 3 times in each nasal passage per day. The duration of treatment depends on the course of the disease and should not exceed 7 consecutive days. The metered spray ensures dosing accuracy and proper distribution of the solution over the surface of the nasal mucosa. Before use, it is necessary to make the dispenser ready by performing several injection movements until the spray begins to be released into the air. With further use, the dosing device will be ready for immediate use. Apply the spray as follows: – thoroughly clean the nose before using the drug; – hold the bottle vertically, supporting the bottom with your thumb and placing the tip between two fingers; – slightly tilt the bottle and insert the tip into the nostril; – inject and at the same time take a light breath through the nose; – after use, before closing the tip with a cap, clean and dry the tip; – in order to prevent infection, each vial with the drug can only be used by one person. The last application is recommended to be carried out immediately before bedtime. Precautions The drug should not be used for more than 7 days in a row. If symptoms persist, see a doctor. Too long or excessive use can lead to the resumption of nasal congestion and / or atrophy of the nasal mucosa. The drug, like other sympathomimetics, should be used with caution in patients who have strong reactions to adrenergic drugs, which manifest themselves as insomnia, dizziness, tremors, cardiac arrhythmias or increased blood pressure. Do not exceed the recommended dose of the drug, especially when treating children and the elderly. The drug should be used with caution in patients with cardiovascular diseases, arterial hypertension, patients with diabetes mellitus, with pheochromocytoma, prostatic hypertrophy, and should not be used in patients receiving treatment with MAO inhibitors and within 2 weeks after stopping their use. The drug contains benzalkonium chloride, which can cause irritation of the nasal mucosa. Use during pregnancy or lactation. The drug should not be used during pregnancy due to the potential vasoconstrictor effect. There is no evidence of any undesirable effect on the infant. It is not known whether xylometazoline is excreted in breast milk, therefore, caution is necessary, and the drug should be used during breastfeeding only as directed by a physician. Fertility. There are no adequate data on the effect of the drug on fertility. Since the systemic exposure of xylometazoline hydrochloride is very low, the likelihood of an effect on fertility is extremely low. Children. The drug should not be used in children under 12 years of age. The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Usually the drug has no or little effect on the ability to drive vehicles or work with other mechanisms. Interaction with other drugs Monoamine oxidase inhibitors (MAO inhibitors): xylometazoline can potentiate the action of monoamine oxidase inhibitors and induce a hypertensive crisis. Do not use xylometazoline in patients who are taking or have taken MAO inhibitors within the last two weeks. Tri- and tetracyclic antidepressants: with the simultaneous use of tri- or tetracyclic antidepressants and sympathomimetic drugs, the sympathomimetic effect of xylometazoline may be enhanced, so the simultaneous use of such drugs is not recommended. When used together with β-blockers, it can cause bronchial spasm or a decrease in blood pressure. Contraindications Hypersensitivity to xylometazoline or any other component of the drug, hyperthyroidism, angle-closure glaucoma, transsphenoidal hypophysectomy and surgical interventions with exposure of the meninges in history, dry rhinitis (rhinitis sicca) or atrophic rhinitis. Active ingredient: xylometazoline; 1 g of spray contains xylometazoline hydrochloride in terms of 100% substance 1 mg; excipients: benzalkonium chloride; eucalyptus oil; disodium edetate; propylene glycol; polyethylene glycol 1500; povidone K-15; hypromellose (substitution type 2910); polysorbate 20; sodium hydrogen phosphate, dodecahydrate; potassium dihydrogen phosphate; purified water. Overdose Excessive topical use of xylometazoline hydrochloride or its accidental ingestion can lead to severe dizziness, sweating, a significant decrease in body temperature, headache, bradycardia, arterial hypertension, respiratory depression, coma and convulsions. High blood pressure can change to low. Young children are more sensitive to toxicity than adults. All patients with suspected overdose should be prescribed appropriate supportive measures, as well as, if necessary, urgent symptomatic treatment under medical supervision. Medical assistance should include observation of the patient for several hours. In case of severe overdose, which is accompanied by cardiac arrest, resuscitation should continue for at least 1 hour. Side effects When prescribing Evkazolin Aqua to people with cardiovascular diseases, systemic cardiovascular disorders were observed. From the immune system: rare (<1/10000): hypersensitivity reaction, including angioedema, rash, itching. From the side of the nervous system: often (³1/100, <1/10): headache. On the part of the organs of vision: rare (<1/10000): temporary visual impairment. From the side of the cardiovascular system: rare (<1/10000): arrhythmia or tachycardia. On the part of the respiratory system, chest and mediastinum: often (³1/100, <1/10): dryness or discomfort from the nasal mucosa. From the gastrointestinal system: often (³1/100, <1/10) nausea. General disorders and reactions at the injection site: often (³1/100, <1/10): burning sensation at the application site. Storage conditions Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Best before date. 2 years. Do not use the drug after the expiration date indicated on the package. Buy Evkazolin Aqua nasal spray 1mg/g 10g №1