Dicynon tablets 250mg №10×10

Name:
Dicynon tab. 250mg No. 100 Storage conditions Tablets should be stored out of the reach of children, protected from light and moisture at a temperature not exceeding 25°C. Shelf life from date of manufacture5 years
Description:
of goods Tablets of white or almost white color, round, biconvex. Pharmacological action Hemostatic drug. The drug increases the formation of mucopolysaccharides of large molecular weight in the walls of capillaries and increases the stability of capillaries, normalizes their permeability during pathological processes, and improves microcirculation. It has a hemostatic effect, which is due to the activation of the formation of thromboplastin at the site of damage to small vessels. The drug stimulates the formation of blood coagulation factor III, normalizes platelet adhesion. The drug does not affect prothrombin time, does not have hypercoagulable properties and does not contribute to the formation of blood clots. After intravenous administration, the drug begins to act after 5-15 minutes; the maximum effect is observed after 1 hour, the duration of action is 4-6 hours. After oral administration, the drug is rapidly and almost completely absorbed. After taking the drug at a dose of 50 mg, Cmax is reached after 4 hours and is 15 μg / ml. Etamzilat crosses the placental barrier and is excreted in breast milk. Withdrawal About 72% of the administered dose is excreted by the kidneys during the first 24 hours unchanged. After intravenous administration, T1 / 2 is about 2 hours, after oral administration, T1 / 2 is about 8 hours. obstetrics, urology, dentistry, ophthalmology and plastic surgery; hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women with intrauterine contraceptives, epistaxis, bleeding gums; diabetic microangiopathy (hemorrhagic diabetic retinopathy, repeated retinal hemorrhages, hemophthalmos); intracranial hemorrhages in newborns and premature babies. Use during pregnancy and lactation Use during pregnancy is possible only in cases where the potential benefit of therapy for the mother outweighs the possible risk to the fetus. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding. Special instructions Before starting treatment, other causes of bleeding should be excluded. 1 tablet of Dicinon contains 60.5 mg of lactose (the maximum daily dose of lactose should not exceed 5 g). Do not prescribe the drug to patients with congenital glucose intolerance, lapp lactase deficiency (lactase deficiency in some peoples of the North) or glucose-galactose malabsorption syndrome. If the solution for intramuscular and intravenous administration becomes stained, it should not be used. The solution for i / m and / in the introduction is intended only for use in hospitals and clinics. Solution for intramuscular and intravenous injection can be applied topically: a sterile swab or gauze is soaked in solution and applied to the wound (for example, skin graft, tooth extraction). Influence on the ability to drive vehicles and control mechanisms No special precautions are required. With caution (Precautions) With caution, the drug should be prescribed for thrombosis, a history of thromboembolism, bleeding in the presence of an overdose of anticoagulants. Contraindications Acute porphyria; hemoblastosis in children (lymphoblastic and myeloblastic leukemia, osteosarcoma); thrombosis; thromboembolism; hypersensitivity to the components of the drug and sodium sulfite; hypersensitivity to sodium sulfite (solution for intravenous and intramuscular administration). With caution, the drug should be prescribed for thrombosis, a history of thromboembolism, bleeding against the background of an overdose of anticoagulants. Dosing and Administration The optimal daily dose for adults is 10-20 mg / kg of body weight, divided into 3-4 doses. In most cases, a single dose is 250-500 mg 3-4 times / day. In exceptional cases, a single dose may be increased to 750 mg 3-4 times / day. With menorrhagia, 750-1000 mg / day is prescribed, starting from the 5th day of the expected menstruation until the 5th day of the next menstrual cycle. In the postoperative period, the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears. Children are prescribed in a daily dose of 10-15 mg / kg in 3-4 doses. Overdose Data on overdose of Dicinon are not available. Side effects From the side of the central nervous system and peripheral nervous system: headache, dizziness, paresthesia of the lower extremities. From the digestive system: nausea, heartburn, heaviness in the epigastric region. Other: allergic reactions, hyperemia of the skin of the face, decrease in systolic blood pressure. Composition Active substance: etamsylate 250 mg; Excipients: anhydrous citric acid, corn starch, povidone K25, magnesium stearate, lactose. Interaction with other drugs Administration at a dose of 10 mg/kg of body weight 1 hour before the administration of dextrans prevents their antiaggregant effect. The introduction of Dicinon after the introduction of dextrans does not have a hemostatic effect. Perhaps a combination with aminocaproic acid and menadione sodium bisulfite. Pharmaceutical interaction Pharmaceutical incompatible (in the same syringe) with other drugs. Incompatible with sodium bicarbonate injection and sodium lactate solution. Release form Tablets are white or almost white, round, biconvex. 1 tab. Active substance: etamsylate 250 mg; Excipients: anhydrous citric acid, corn starch, povidone K25, magnesium stearate, lactose. 10 pieces. – blisters (10) – packs of cardboard. Buy Dicinon tablets 250mg No. 10×10 Price for Dicinon tablets 250mg No. 10×10