Cytoflavin tablets p / o enteric №10×5

Name:
Cytoflavin tab. No. 10×5
Description:
General characteristics Round biconvex tablets, coated with red color. The cross section shows two layers. The core of the tablets is yellow to yellow-orange in color. The main active substance Inosine + nicotinamide + riboflavin + succinic acid Release formtablets Pharmacological propertiesPharmacodynamicsPharmacological effects are due to the complex effect of the components that make up the drug CYTOFLAVIN®. Succinic acid ? endogenous intracellular metabolite of the Krebs cycle, which performs a universal energy-synthesizing function in the cells of the body. With the participation of the coenzyme flavin adenine dinucleotide (FAD), succinic acid is quickly transformed by the mitochondrial enzyme succinate dehydrogenase into fumaric acid and then into other metabolites of the tricarboxylic acid cycle. Stimulates aerobic glycolysis and ATP synthesis in cells. The end products of succinic acid metabolism in the Krebs cycle are carbon dioxide and water. Succinic acid improves tissue respiration by activating electron transport in mitochondria. Riboflavin (vitamin B2) is a flavin coenzyme (FAD) that activates succinate dehydrogenase and some redox reactions of the Krebs cycle. Nicotinamide (vitamin PP) nicotinic acid amide. Nicotinamide in cells through a cascade of biochemical reactions is transformed into the form of nicotinamide adenine nucleotide (NAD) and its phosphate (NADP), activating nicotinamide-dependent Krebs cycle enzymes necessary for cellular respiration and stimulation of ATP synthesis. Inosine is a derivative of purine, a precursor of ATP. It has the ability to activate a number of enzymes of the Krebs cycle, stimulating the synthesis of key nucleotide enzymes? flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD). Thus, all components of Cytoflavin are natural metabolites of the body and stimulate tissue respiration. Metabolic energy correction, antihypoxic and antioxidant activity of the drug, which determine the pharmacological properties and therapeutic efficacy of the components, are due to the complementary action of succinic acid, inosine, nicotinamide and riboflavin. Pharmacokinetics CYTOFLAVIN® has a high bioavailability. Succinic acid, when taken orally, penetrates from the gastrointestinal tract into the blood and tissues, participating in energy metabolism reactions, and completely decomposes to the final products of metabolism (carbon dioxide and water) after 30 minutes. Inosine is well absorbed from the gastrointestinal tract. Time to reach peak blood concentration ? 5 hours, mean retention time in blood ? 5.5 hours, equilibrium volume of distribution about 20 liters. Inosine is metabolized in the liver to form inosine monophosphate, followed by its oxidation to uric acid. In a small amount excreted by the kidneys. Nicotinamide is rapidly distributed in all tissues (equilibrium volume of distribution is about 500 liters). Time to reach peak blood concentration ? 2 hours, mean retention time in blood ? 4.5 hours. Nicotinamide crosses the placenta and into breast milk, is metabolized in the liver to form N-methylnicotinamide, and excreted by the kidneys. Riboflavin is rapidly absorbed from the gastrointestinal tract, distributed unevenly (the largest amount in the myocardium, liver, kidneys), transformed into flavin adenine mononucleotide (FMN) and flavin adenine dinucleotide (FAD) in mitochondria. Penetrates through the placenta and into breast milk; excreted by the kidneys, mainly in the form of metabolites. Indications for use In adults in complex therapy: the consequences of cerebral infarction; other cerebrovascular diseases (cerebral atherosclerosis, hypertensive encephalopathy); neurasthenia (increased irritability, fatigue, loss of ability for prolonged mental and physical stress). Method of application and dose Inside 2 tablets 2 times a day day with an interval between doses of 8? 10 hours. Tablets should be taken at least 30 minutes before meals, without chewing, with water (100 ml). It is recommended to take the drug in the morning and afternoon (no later than 18 hours). Duration of the course of treatment? 25 days. Conducting a second course is possible with an interval of at least 1 month. Tactics of the patient when skipping the next dose of the drug If the next dose of the drug is missed, then at the first opportunity, without doubling the dosage, continue the course according to the initiated scheme. Use in elderly patients In elderly patients, a change in dosing regimen is not required. Application in patients with impaired renal function No change in dosing regimen is required. Use in patients with impaired liver function No change in dosing regimen is required. Use in children Not recommended for use in children under 18 years of age due to insufficient data on efficacy and safety. Application during pregnancy and lactation It is not recommended to take during pregnancy and lactation due to the lack of clinical data on the efficacy and safety of the drug during these periods. Precautions Cytoflavin® should be used with caution in diseases of the digestive system (erosion, gastric and / or duodenal ulcers, gastritis and duodenitis (in the acute stage)), arterial hypotension, nephrolithiasis, concomitant gout, hyperuricemia. In hypertension, dose adjustment of antihypertensive drugs may be required. In patients with diabetes mellitus, treatment should be carried out under the control of blood glucose concentration. Perhaps intense staining of urine in yellow. The composition of the shells of the tablets includes the dye azorubine (carmoisine) E 122, which can cause allergic reactions. Influence on the ability to drive vehicles and mechanisms Cytoflavin® does not affect the ability to drive vehicles and mechanisms. Interaction with other drugs Succinic acid, inosine and nicotinamide are compatible with other drugs. Riboflavin reduces the activity of some antibiotics (tetracyclines, erythromycin, lincomycin), is incompatible with streptomycin. Ethanol, tricyclic antidepressants, blockers of tubular secretion reduce the absorption of riboflavin, and thyroid hormones accelerate its metabolism. ContraindicationsIndividual intolerance to the components of the drug. Composed of 1 tablet: active substances: succinic acid? 0.300 g, inosine (riboxin)? 0.050 g, nicotinamide? 0.025 g, riboflavin sodium phosphate (riboflavin) 0.005 g; excipients: povidone, calcium stearate, hypromellose, polysorbate 80; enteric coating: methacrylic acid and ethyl acrylate copolymer 1:1, propylene glycol, dye azorubine (carmoisine) (E122). Release form Enteric-coated tablets. Overdose So far, no cases of drug overdose have been established. Side effects Like all medicines, CYTOFLAVIN® can cause side effects, although not everyone gets them. The frequency of occurrence of adverse reactions is indicated in accordance with the classification recommended by WHO: very common (? 1/10); frequent (? 1/100? < 1/10); infrequent (? 1/1000? < 1/100); rare ( ? 1/10000 ? < 1/1000); very rare (< 1/10000); frequency unknown (frequency cannot be determined from the available data). Immune system disorders: very rare ? hypersensitivity reactions. Nervous system disorders: very rare ? headache. Vascular disorders: very rare hyperemia. Skin disorders: very rare itching. Gastrointestinal disorders: very rare pain and discomfort in the epigastric region. Metabolic disorders: very rare transient hypoglycemia, hyperuricemia, exacerbation of concomitant gout. Reporting adverse reactions It is important to report suspected adverse reactions after registration of a medicinal product in order to ensure continuous monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are encouraged to report any suspected adverse drug reactions through national adverse drug reaction and drug failure reporting systems. The patient, if he has any undesirable reactions, is recommended to consult a doctor. This recommendation applies to any possible adverse reactions, including those not listed in the instructions for use of the drug. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage conditions In a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Buy Cytoflavin tablets p / o enteric soluble No. 10x5