Chondromed solution for intramuscular injection 200mg/2ml in ampoules №5×2

Name Chondromed solution for intramuscular injection 200 mg/2 ml in amp. The main active ingredient Chondroitin sulfate Release form Solution for intramuscular injection. Dosage 200 mg / 2 ml Pharmacodynamics The main active ingredients of the drug are sodium salts of chondroitin sulfate A and C (average molecular weight 11000 daltons). Chondroitin sulfate is a high molecular weight mucopolysaccharide. It is the main component of proteoglycans, which, together with collagen fibers, make up the cartilage matrix. The drug has an anti-inflammatory, analgesic effect. Suppresses the activity of enzymes that cause degradation of articular cartilage: inhibits metalloproteinases, in particular, leukocyte elastase. Reduces the activity of hyaluronidase. Partially blocks the release of free oxygen radicals; contributes to the blocking of chemotaxis, antigenic determinants. Anti-inflammatory and analgesic effects are achieved by reducing the release of inflammatory mediators and pain factors into the synovial fluid through synoviocytes and macrophages of the synovial membrane, as well as by suppressing the secretion of leukotriene B4 and prostaglandin E2. The use of the drug prevents the contraction of the connective tissue, plays the role of lubricating the articular surfaces, normalizes the production of joint fluid, improves joint mobility, helps reduce pain intensity, and improves the quality of life. Pharmacokinetics After intramuscular administration, the maximum concentration is reached within 1 hour, then the concentration of the drug slowly decreases over 2 days. Accumulates mainly in cartilaginous tissue (maximum concentration in articular cartilage reaches 48 hours); the synovium is not an obstacle to its penetration into the joint cavity. It is excreted from the body mainly by the kidneys within 24 hours. Indications for use Degenerative-dystrophic diseases of the joints and spine: primary arthrosis; osteoarthritis with a primary lesion of large joints; intervertebral osteochondrosis. Method of application and dose The drug is administered intramuscularly in 1 ml every other day. With good tolerance, the dose is increased to 2 ml, starting with the fourth injection. The course of treatment is 25-35 injections. It is advisable to repeat the course of treatment 6 months after consulting a doctor. Use during pregnancy and lactation It is not recommended to use this drug during pregnancy and lactation due to the lack of data confirming the safety of its use in women during this period. Use in children It is not recommended to prescribe the drug to children, due to the lack of data on the efficacy and safety of use in children. Influence on the ability to drive vehicles and control mechanisms Does not affect the ability to drive vehicles or potentially dangerous mechanisms. Precautions If allergic reactions or hemorrhages occur, treatment should be discontinued. To achieve a stable clinical effect, at least 25 injections of Chondromed are required. The effect persists for a long time for many months after the end of the course of treatment. To prevent exacerbation, repeated courses of treatment are indicated. Interaction with other drugs When combined with non-steroidal anti-inflammatory drugs Chondromed allows you to reduce their dose. It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, which requires more frequent monitoring of blood coagulation parameters when used together. Contraindications Increased individual sensitivity to any of the components of the drug, a tendency to bleeding, thrombophlebitis, pregnancy, lactation (for the duration of treatment, breastfeeding should be stopped). Children under 15 years of age (efficacy and safety have not been established). With caution: in case of blood clotting disorders, diabetes mellitus, in people with increased body weight, in patients receiving a low-salt diet, children under 18 years of age, with impaired renal function, in women planning pregnancy. Composition One ampoule contains: Active substance: chondroitin sulfate (as sodium chondroitin sulfate) – 200 mg. Excipients: benzyl alcohol, 0.1M sodium hydroxide solution or 0.1M hydrochloric acid solution – up to a pH value of 6.0 – 7.5, water for injection up to 2 ml. OverdoseSymptoms: allergic reactions, hemorrhages at the injection site. Treatment: if necessary, symptomatic therapy is indicated. Side effects Allergic reactions: skin itching, erythema, urticaria, dermatitis. From the digestive system: rarely – nausea, vomiting, diarrhea. Other: bleeding at the injection site. Storage conditions In a place protected from light at a temperature not exceeding 25? Keep out of the reach of children. Buy Chondromed solution for intramuscular injection 200mg/2ml in ampoules No. 5×2 Price for Chondromed solution for intramuscular injection 200mg/2ml in ampoules No.5×2