Blokordil tablets 50mg №10×2

Name:
Blocordil tab 50mg in a blister. in pack. No. 10×2
Description:
Tablets 50 mg: white, round, slightly biconvex tablets with bevelled edges and a notch on one side. The notch is not designed to break the tablet. The main active ingredient captopril Release form Tablets Dosage 50 mg Special instructions Caution should be used when indicating a history of angioedema during therapy with ACE inhibitors, hereditary or idiopathic angioedema, with aortic stenosis, cerebro- and cardiovascular diseases (including with cerebrovascular insufficiency , IHD, coronary insufficiency), severe autoimmune connective tissue diseases (including SLE, scleroderma), with oppression of bone marrow hematopoiesis, diabetes mellitus, hyperkalemia, bilateral renal artery stenosis, stenosis of the artery of a single kidney, condition after kidney transplantation, renal and / or liver failure, against the background of a sodium-restricted diet, conditions accompanied by a decrease in BCC (including diarrhea, vomiting), in elderly patients. In patients with chronic heart failure, captopril is used under close medical supervision. Hypotension that occurs during surgery while taking captopril is eliminated by replenishing the volume of fluid. The simultaneous use of potassium-sparing diuretics and potassium preparations should be avoided, especially in patients with renal insufficiency and diabetes mellitus. When taking captopril, a false positive reaction can be observed in the analysis of urine for acetone. The use of captopril in children is possible only if other drugs are ineffective. Impact on the ability to drive vehicles and control mechanisms Care must be taken when driving vehicles or performing other work that requires increased attention, because. dizziness is possible, especially after the initial dose of captopril. Pharmacological actionBlocordil is a drug designed to lower blood pressure (BP). It belongs to the group of ACE inhibitors. When using the drug, the blood vessels dilate, which leads to a decrease in blood pressure and an increase in the flow of blood and oxygen to the heart muscle and other organs. Indications for useHypertension Blockordil is indicated for the treatment of arterial hypertension. Heart failure Blokordil is indicated for the treatment of chronic heart failure with decreased left ventricular systolic function. Myocardial infarction Short-term (4 weeks) use of Blockordil is used in clinically stable patients within the first 24 hours after a heart attack. Long-term prevention of symptomatic heart failure Blockordil is indicated for clinically stable patients with asymptomatic left ventricular dysfunction. Type I diabetic nephropathy Blokordil is indicated for the treatment of diabetic nephropathy in insulin-dependent diabetes mellitus. Dosage and administration The drug should be taken according to the doctor’s recommendations. If you have any questions, it is recommended to consult your doctor. Dosage Arterial hypertension Recommended starting dose: 12.5 mg – 25 mg two to three times a day. Maximum recommended daily dose: 150 mg. Heart failure Recommended starting dose: 12.5 mg two to three times a day. Maximum recommended daily dose: 150 mg. Myocardial infarction It is recommended to start treatment between 3 and 16 days after myocardial infarction at 12.5 mg of captopril three times a day. Gradually increase the dose to 50 mg of captopril three times a day. Diabetic Nephropathy Recommended dose: Captopril 25 mg three times a day. Renal insufficiency Since captopril is excreted mainly through the kidneys, in patients with renal insufficiency, the dosage should be reduced and the dosing interval should be increased. In patients with mild renal insufficiency (creatinine clearance 60-89 ml / min / 1.73 m2 (1-1.49 ml / s / 1.73 m2)) dose adjustment and increase in the dosing interval is not required. In moderate renal failure (creatinine clearance 30–59 ml/min/1.73 m2 (0.5–0.99 ml/s/1.73 m2)) take 75% of the recommended dose every 12–18 hours, while in severe renal failure (creatinine clearance 15-29 ml / min / 1.73 m2 (0.25-0.49 ml / s / 1.73 m2)) – 50% of the recommended dose every 24 hours. If concomitant diuretic therapy is required for patients with severe renal insufficiency, then loop diuretics (eg, furosemide) are preferred over thiazide diuretics. Use in children and adolescents The efficacy and safety of captopril in children and adolescents under 18 years of age have not been fully studied. Captopril is recommended for this category of patients only when treatment with other antihypertensive drugs is not effective enough. Recommended starting dose for children: 0.3 mg/kg body weight three times a day. The dose may be gradually increased until the optimal therapeutic effect is achieved or up to the maximum recommended dose: 6 mg/kg body weight. Available doses of tablets do not allow correction for children weighing less than 40 kg. Dosing and Administration Blokordil should be taken before meals, since the simultaneous intake of food slows down the absorption of captopril and reduces its bioavailability. If captopril is placed under the tongue, then its absorption is faster than when taken orally. Do not take a double dose to make up for a missed dose. If you miss the time of taking the drug, then take the missed tablet as soon as possible. If there are several hours left until the next dose, then wait and take the drug according to the usual scheme – do not double the dose. After discontinuation of treatment, an increase in blood pressure and, accordingly, an increase in the risk of complications associated with arterial hypertension, especially from the heart, brain and kidneys, is possible. The condition of patients with heart failure may worsen to such an extent that hospitalization is required. In patients with a history of myocardial infarction, there is a risk of heart failure after discontinuation of treatment. In patients with kidney disease, the possibility of worsening liver function. Use during pregnancy and lactation If you are pregnant or breastfeeding, or think you are pregnant or plan to become pregnant, please consult your doctor before taking the drug. Pregnancy You should tell your doctor if you are (or think you are) pregnant. Your doctor will usually tell you to stop taking captopril before or just after you become pregnant and start a different drug. Blockordil is not recommended during the first 3 months of pregnancy. Blockordil is contraindicated later in life because it could cause serious harm to your baby. Lactation Tell your doctor if you are breastfeeding. Blockordil is not recommended during lactation. Your doctor will suggest a different treatment for you, especially if you are breastfeeding a premature or newborn baby. Later, captopril may be considered in breastfeeding mothers when treatment is needed for the mother and the baby is monitored for any side effects. Precautions Within a few hours after taking the first dose of the drug, an excessive decrease in blood pressure (arterial hypotension) is possible, accompanied by nausea, rapid heartbeat and loss of consciousness. More often, such phenomena occur in patients with heart failure or severe renal impairment, after diarrhea or vomiting, with increased sweating, as well as in those taking diuretic drugs (diuretics) or on a salt-free diet. To avoid the above, before starting treatment with Blockordil, diuretics and a salt-free diet should be discontinued if possible. Severe consequences are rare. In the event of arterial hypotension, the patient must be transferred to a horizontal position with raised legs and a doctor should be called. Transient hypotension is not a reason to stop captopril therapy. Subsequent doses of the drug are usually well tolerated. With repeated episodes, you should consult a doctor. The patient should inform the doctor that he is taking other drugs for the treatment of diseases of the heart and cerebral vessels (including those associated with atherosclerosis), since in this case there is an increased risk of an excessive fall in blood pressure and a decrease in perfusion of vital organs. Your kidney function will be monitored by your doctor before and during captopril therapy. Tell your doctor if you have chronic kidney disease or if you are taking potassium-sparing diuretics (eg, spironolactone, amiloride, triamterene) or potassium supplements. The concomitant use of these medicinal products is not recommended. If during treatment you feel muscle weakness or irregular heartbeat, tell your doctor immediately. The patient should inform the doctor about the presence of diabetes. Some patients may need to reduce the dose of insulin or oral hypoglycemic agents. Patients over 65 years of age have an increased risk of adverse reactions. During the use of captopril, there is a risk of neutropenia, usually in patients with pre-existing connective tissue diseases (systemic lupus erythematosus, diffuse scleroderma), impaired renal function or being treated with immunosuppressive drugs. If you have any signs of an infectious disease (sore throat, fever, cough), you should immediately consult a doctor. During treatment with ACE inhibitors, a persistent, non-productive cough may occur, which stops after discontinuation of treatment. Before surgery or anesthesia, tell your doctor (or dentist) that you are taking captopril. When performing hemodialysis or apheresis using some types of membranes, hypersensitivity reactions may occur. If such procedures are planned, the patient should inform the doctor that he is taking captopril. Patients undergoing desensitization against wasp or bee venom may experience unwanted hypersensitivity reactions. If this type of treatment is planned, the patient should inform the doctor that he is taking captopril. During treatment with captopril, jaundice or an increase in liver enzymes may occur. In this case, you should immediately stop treatment and consult a doctor. You should tell your doctor if you are (or think you are) pregnant. Captopril is not recommended during the first 3 months of pregnancy. Captopril should not be taken at a later date because it could cause serious harm to your baby. You should tell your doctor if you are taking the following medicines to treat high blood pressure: angiotensin II receptor blockers (also known as sartans, eg valsartan, telmisartan, irbesartan), especially if you have kidney disease associated with diabetes; aliskiren. In cases where concomitant use is absolutely indicated, careful observation by a specialist and mandatory monitoring of kidney function, water and electrolyte balance and blood pressure are necessary. Special information about some of the ingredients in Blokordil contains lactose. The drug is not recommended for patients with rare congenital galactose intolerance, lactase deficiency or malabsorption of glucose-galactose. Taken with food, drink or alcohol Tablets should be taken on an empty stomach with some liquid at least one hour before or two hours after a meal. During therapy with captopril, it is not recommended to drink alcohol, since ethanol enhances the hypotensive effect of the drug. Interactions with other drugs Tell your doctor if you are taking or have recently taken the following medicines: medicines to lower blood pressure (beta-blockers, alpha-1 receptor blockers, centrally acting alpha-2 agonists, calcium channel blockers); diuretics (diuretics); drugs for the treatment of heart failure; preparations for the treatment of rheumatic diseases; medicines to treat diabetes (insulin or oral antidiabetic medicines); drugs for the treatment of mental disorders (antidepressants, antipsychotics, lithium preparations); aldesleukin; anesthetics; non-steroidal anti-inflammatory drugs or acetylsalicylic acid to relieve pain (analgesic); drugs for the treatment of opiate overdoses (naloxone); vasodilators (minoxidil, alprostadil, nitrates); potassium preparations; hormonal drugs (estrogen, including contraceptives); immunosuppressive drugs, including corticosteroids; muscle relaxants; drugs for the treatment of Parkinson’s disease; drugs to treat anemia (epoetin); drugs for the treatment of peptic ulcer (carbenoxolone); anti-gout agents (probenecid); drugs for the treatment of gout (allopurinol). The simultaneous use of captopril and the listed medicinal products may lead to a decrease in their effect, an increase in the risk of side effects or to affect the effect of captopril. Before surgery, tell your doctor that you are taking captopril. You may need to change the dose of the drug and / or change the drug: if you are using an angiotensin II receptor blocker or aliskiren. Contraindications The drug should not be taken by patients: with hypersensitivity to captopril, other ACE inhibitors or any of the excipients of the drug; who have previously experienced hypersensitivity reactions, accompanied by swelling of the lips, face, neck, arms, legs, difficulty breathing and hoarseness during therapy with ACE inhibitors; who previously had Quincke’s edema; with bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney; with porphyria; in the second and third trimesters of pregnancy (it is preferable to avoid taking captopril also in the earlier period of pregnancy); the simultaneous use of Blokordil and aliskiren-containing drugs is contraindicated in patients with diabetes mellitus or renal insufficiency. Composition One tablet contains Active substance: captopril 12.5 mg, 25 mg or 50 mg. Excipients: microcrystalline cellulose, lactose monohydrate, corn starch, stearic acid. Overdose The most common symptoms of overdose are: a pronounced decrease in blood pressure, heart rate, shock, stupor. When these symptoms appear, the patient should take a horizontal position with raised legs and call a doctor. If you take a large number of tablets at a time, you should inform your doctor and try to induce vomiting to remove the medicine from the stomach. Side effects Like all medicines, Blockordil can cause side effects in isolated cases. Side effects of Blockordil are usually mild and temporary and do not require discontinuation of treatment. Classification of the incidence of side effects according to the World Health Organization: very frequent (? 1/10); frequent (? 1/100 to < 1/10); infrequent (? 1/1000 to < 1/100); rare (? 1/10,000 to < 1/1,000); very rare (< 1/10,000), frequency unknown (cannot be estimated from the available data). Laboratory parameters Very rare: proteinuria, hyperkalemia, hyponatremia, increased levels of urea, creatinine and bilirubin, decreased serum hemoglobin, decreased hematocrit, leukopenia, thrombocytopenia, increased ANA titer, increased erythrocyte sedimentation Metabolism and nutrition disorders Rare: anorexia Very rare: hyperkalemia, hypoglycemia Cardiac disorders Uncommon: tachycardia, tachyarrhythmia, angina pectoris, palpitations Very rare: cardiac arrest, cardiogenic shock Blood and lymphatic system disorders Very rare: neutropenia/agranulocytosis, pancytopenia (especially in patients with renal insufficiency), anemia ( aplastic or hemolytic), thrombocytopenia, lymphadenopathy, eosinophilia, autoimmune disease and/or elevated ANA titer Nervous system disorders Common: taste disturbances, dizziness Rare: drowsiness, headache, paresthesia Very rare: cerebrovascular events I, including stroke, syncope Visual disorders Very rare: blurred vision Respiratory, thoracic and mediastinal disorders Common: dry, irritating (unproductive) cough, which usually resolves within a few weeks after stopping treatment, and shortness of breath Very rare: bronchospasm, rhinitis, allergic alveolitis/eosinophilic pneumonia Gastrointestinal disorders Common: nausea, vomiting, gastritis, abdominal pain, diarrhea, constipation, dry mouth Rare: aphthous ulcers in the mouth and tongue, intestinal angioedema Very rare: glossitis, peptic ulcer, pancreatitis Renal and urinary tract disorders Rare: renal failure, including polyuria, oliguria and frequent urination Very rare: nephrotic syndrome Skin and subcutaneous tissue disorders Common: pruritus with rash or without, rash and alopecia Uncommon: angioedema Very rare: urticaria, syndrome C Steven-Johnson, erythema multiforme, photosensitivity, erythroderma, pemphigoid reaction and exfoliative dermatitis Musculoskeletal, connective and bone disorders Very rare: myalgia, arthralgia Vascular disorders Uncommon: hypotension, Raynaud's syndrome, erythema, pallor General complications Uncommon : chest pain, fatigue, weakness Very rare: fever Hepatobiliary disorders Very rare: liver failure, cholestasis (including jaundice), hepatitis including necrosis, elevated liver enzymes and increased bilirubin levels Reproductive system and breast disorders Very rare: impotence, gynecomastia Psychiatric disorders Common: sleep disturbances Very rare: confusion, depression If you experience any of the side effects listed or not listed in this package insert, consult your doctor. Storage conditions Store in a place protected from moisture and light, at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life - 3 years. Do not use the drug after the expiration date indicated on the package. The expiry date refers to the last day of the month. Buy Blockordil tablets 50mg No. 10x2